Results 71 to 80 of about 34,120 (225)

Advances in Parahydrogen‐Induced Polarization for Nuclear Magnetic Resonance of Peptides, Proteins, and Biopolymers

ChemistryEurope, EarlyView.
Hyperpolarization by parahydrogen‐induced polarization enhances the sensitivity of nuclear magnetic resonance spectroscopy of amino acids, peptides, mini‐proteins, and biopolymers using nonnatural amino acids with unsaturated side chains up to three orders of magnitude.
Gerd Buntkowsky
wiley   +1 more source

Understanding the in vivo Uptake Kinetics of a Phosphatidylethanolamine-binding Agent \u3csup\u3e99m\u3c/sup\u3eTc-Duramycin [PDF]

, 2012
Introduction 99mTc-Duramycin is a peptide-based molecular probe that binds specifically to phosphatidylethanolamine (PE). The goal was to characterize the kinetics of molecular interactions between 99mTc-Duramycin and the target tissue.
Audi, Said H., Capacete, Joseph, Fang, Wei, Li, Zhixin, Liu, Yu, Shu, Laura G., Zhao, Ming   +6 more
core   +1 more source

Blood-brain barrier transport kinetics of NOTA-modified proteins : the somatropin case [PDF]

, 2020
BACKGROUND: Chemical modifications such as PEG, polyamine and radiolabeling on proteins can alter their pharmacokinetic behaviour and their blood-brain barrier (BBB) transport characteristics. NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid, is a
Bracke, Nathalie, De Spiegeleer, Bart, Janssens, Yorick, Maes, Alex, Sathekge, Mike, Tack, Liesa, Van De Wiele, Christophe, Wynendaele, Evelien   +7 more
core   +1 more source

Capability Development in the European Medicines Regulatory Network—A European Learning Needs Analysis and Survey Study

Clinical Pharmacology &Therapeutics, EarlyView.
The European Medicines Regulatory Network plays a critical role in safeguarding public health through the assessment and supervision of human medicines. However, rapid scientific and technological advancements have exposed capability deficits across the network, threatening timely and effective regulatory decision‐making.
Naomi Beard, Marko J. Kallio, Luca Kosec, Ulrika Espefält Westin, on behalf of the IncreaseNET consortium   +4 more
wiley   +1 more source

Enhanced contrast in FAP-targeting PET imaging with 61Cu-labeled FAP inhibitors: development and preclinical evaluation of novel [61Cu]Cu-Kalios PET radioligands

EJNMMI Radiopharmacy and Chemistry
Background Fibroblast activation protein (FAP)-targeting radioligands have gained attention for the ability to image multiple tumor types. Current FAP-targeting radioligands are labeled with 68Ga and 18F, but their short half-lives limit distribution ...
Jacopo Millul, Tais Basaco Bernabeu, Raghuvir H. Gaonkar, Francesco De Rose, Leila Jaafar-Thiel, Gary A. Ulaner, Rosalba Mansi, Melpomeni Fani   +7 more
doaj   +1 more source

Investigation of the Putative Relationship Between Copper Transport and the Anticancer Activity of Cisplatin in Ductal Pancreatic Adenocarcinoma

Cells
Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous cancer with a severe stromal reaction mediated by pancreatic stellate cells (PSCs), leading to increased resistance to chemotherapy and radiotherapy.
Alina Doctor, Jonas Schädlich, Sandra Hauser, Jens Pietzsch   +3 more
doaj   +1 more source

Optimization of Reaction Conditions in the Production of Gadolinium Diethylenetriamine Pentaacetate-Folate [PDF]

, 2015
A previous study has performed the laboratory-scale synthesis and characterization of Gadolinium Diethylenetriaminepentaacetate-Folate. Some parameters associated with the synthesis have been defined.
Anggraeni, A., Fauzia, R. P., Gunawan, A. H., Mutalib, A.   +3 more
core  

Comparative evaluation of [(99m)tc]tilmanocept for sentinel lymph node mapping in breast cancer patients: results of two phase 3 trials. [PDF]

, 2013
BackgroundSentinel lymph node (SLN) surgery is used worldwide for staging breast cancer patients and helps limit axillary lymph node dissection.
Avisar, Eli, Christman, Lori, Cox, Charles, Deck, Kenneth, Faries, Mark, Frazier, Thomas G, Hall, Nathan C, Han, Linda K, Hoh, Carl K, King, Dennis W, Krontiras, Helen, Limmer, Karl K, Povoski, Stephen P, Schneebaum, Schlomo, Vera, David R, Wallace, Anne M   +15 more
core   +2 more sources

Medical Imaging Graduates' Knowledge About Infection Prevention and Control in Pharmaceutical Administration Including Contrast in CT and Radiopharmaceutical in Nuclear Medicine

Journal of Medical Radiation Sciences, EarlyView.
This study explores infection prevention and control (IPC) knowledge and training among radiographers and nuclear medicine technologists regarding pharmaceutical administration in medical imaging, including contrast in computed tomography and radiopharmaceuticals in nuclear medicine.
Rogayah Freihat, Peter Kench, Sarah Lewis, Yobelli Jimenez   +3 more
wiley   +1 more source

Production of the PET radionuclide 61Cu via the 62Ni(p,2n)61Cu nuclear reaction

EJNMMI Radiopharmacy and Chemistry
Background There are only a handful of true theranostic matched pairs, and in particular the theranostic radiocopper trio 61Cu, 64Cu and 67Cu, for diagnosis and therapy respectively, is a very attractive candidate. In fact, the alternative of two imaging
Santiago Andrés Brühlmann, Martin Walther, Klaus Kopka, Martin Kreller   +3 more
doaj   +1 more source