Results 71 to 80 of about 22,462 (308)

Hollow-fiber bioreactor production of extracellular vesicles from human bone marrow mesenchymal stromal cells yields nanovesicles that mirrors the immuno-modulatory antigenic signature of the producer cell

Stem Cell Research & Therapy, 2021
Background Extracellular vesicles (EVs) produced by human bone marrow-derived mesenchymal stromal cells (hBM-MSCs) are currently investigated for their clinical effectiveness towards immune-mediated diseases.
Jonathan Gobin, Gauri Muradia, Jelica Mehic, Carole Westwood, Lauren Couvrette, Andrew Stalker, Stewart Bigelow, Christian C. Luebbert, Frédéric St-Denis Bissonnette, Michael J. W. Johnston, Simon Sauvé, Roger Y. Tam, Lisheng Wang, Michael Rosu-Myles, Jessie R. Lavoie   +14 more
doaj   +1 more source

Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition

Chemistry &Biodiversity, Accepted Article.
Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb, Morkoss Fakhry, Ali K. Albuhadily, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha   +5 more
wiley   +1 more source

Bioorthogonal Postlabeling Reveals Nuclear Localization of a Highly Cytotoxic Half‐Sandwich Ir(III) Tetrazine Complex in Live Cells

ChemBioChem, EarlyView.
This study reports the synthesis of five tetrazine‐coordinated, half‐sandwich iridium complexes and extensively describe their reactivity. Live cell fluorescent bioorthogonal labeling reveals the nuclear tropism of the most cytotoxic complex. Intracellular imaging of anticancer metallodrugs often relies on prelabeling with organic fluorophores, which ...
Alfonso Annunziata, Sadek Amhaz, Jérémy Forté, Geoffrey Gontard, Romain Morichon, Joëlle Sobczak‐Thépot, Michèle Salmain   +6 more
wiley   +1 more source

Brain MRI-to-PET Synthesis using 3D Convolutional Attention Networks [PDF]

arXiv, 2022
Accurate quantification of cerebral blood flow (CBF) is essential for the diagnosis and assessment of a wide range of neurological diseases. Positron emission tomography (PET) with radiolabeled water (15O-water) is considered the gold-standard for the measurement of CBF in humans. PET imaging, however, is not widely available because of its prohibitive
arxiv  

Unconventional Nuclides for Radiopharmaceuticals

Molecular Imaging, 2010
Rapid and widespread growth in the use of nuclear medicine for both diagnosis and therapy of disease has been the driving force behind burgeoning research interests in the design of novel radiopharmaceuticals. Until recently, the majority of clinical and basic science research has focused on the development of 11C-, 13N-, 15O-, and 18F ...
Jason S. Lewis, Jason P. Holland, Matthew J. Williamson   +2 more
openaire   +4 more sources

Design and Synthesis of 68Ga‐Labeled Peptide‐Based Heterodimers for Dual Targeting of NTS1 and GRPR

ChemMedChem, EarlyView.
Tumor heterogeneity is challenging for cancer diagnosis and treatment. This study designs and evaluates three gallium‐68 radiolabeled heterodimers targeting two G‐protein coupled receptors, namely NTS1 (neurotensin receptor 1) and GRPR (gastrin‐releasing‐peptide receptor). The branched analogue [68Ga]Ga‐JMV 7266 preserves NTS1 affinity, exhibits higher 
Sacha Bodin, Santo Previti, Emmanuelle Jestin, Emmanuelle Rémond, Delphine Vimont, Frédéric Lamare, Imade Ait‐Arsa, Elif Hindié, Florine Cavelier, Clément Morgat   +9 more
wiley   +1 more source

Evaluation of Actinium-225 Labeled Minigastrin Analogue [²²⁵Ac]Ac-DOTA-PP-F11N for Targeted Alpha Particle Therapy

Pharmaceutics, 2020
The overexpression of cholecystokinin B receptor (CCKBR) in human cancers led to the development of radiolabeled minigastrin analogues for targeted radionuclide therapy, which aims to deliver cytotoxic radiation specifically to cancer cells.
Yun Qin, Stefan Imobersteg, Alain Blanc, Stephan Frank, Roger Schibli, Martin P. Béhé, Michal Grzmil   +6 more
doaj   +1 more source

Advances in Diclofenac Derivatives: Exploring Carborane‐Substituted N‐Methyl and Nitrile Analogs for Anticancer Therapy

ChemMedChem, EarlyView.
By N‐methylation, the intramolecular lactam formation in carborane‐substituted diclofenac analogs is prevented, yielding a series of open‐chain derivatives alongside with their phenyl analogs exhibiting anticancer activity and thus offering a promising avenue for future drug development. This study explores the anticancer potential of N‐methylated open‐
Christoph Selg, Robert Schuster, Aleksandr Kazimir, Peter Lönnecke, Mara Wolniewicz, Jonas Schädlich, Markus Laube, Jens Pietzsch, Vuk Gordić, Tamara Krajnović, Sanja Mijatović, Danijela Maksimović‐Ivanić, Evamarie Hey‐Hawkins   +12 more
wiley   +1 more source

Production of the PET radionuclide 61Cu via the 62Ni(p,2n)61Cu nuclear reaction

EJNMMI Radiopharmacy and Chemistry
Background There are only a handful of true theranostic matched pairs, and in particular the theranostic radiocopper trio 61Cu, 64Cu and 67Cu, for diagnosis and therapy respectively, is a very attractive candidate. In fact, the alternative of two imaging
Santiago Andrés Brühlmann, Martin Walther, Klaus Kopka, Martin Kreller   +3 more
doaj   +1 more source

Radiopharmaceuticals in Acute Porphyria

Clinical Therapeutics, 2016
The acute porphyrias are a group of rare metabolic disorders of the heme biosynthetic pathway. Carriers of the acute porphyria gene are prone to potentially fatal acute attacks, which can be precipitated by drug exposure. It is therefore important to know whether a drug is safe for carriers of the acute porphyria gene.
Nanno Schreuder, Ilahä Mamedova, Frank G A Jansman   +2 more
openaire   +3 more sources