Results 81 to 90 of about 22,462 (308)

Carborane‐based Analogues of Celecoxib and Flurbiprofen, their COX Inhibition Potential and COX Selectivity Index

ChemMedChem, Accepted Article.
The cylcooxygenase isoforms COX‐1 and COX‐2 are involved in the production of prostaglandins in physiological and pathological processes. The overexpression of COX‐2 under inflammatory conditions as well as its role in cancer and neurodegenerative diseases necessitates the need to develop and improve non‐steroidal anti‐inflammatory drugs.
Lea Ueberham, Jonas Schädlich, Kim Schramke, Sebastian Braun, Christoph Selg, Markus Laube, Peter Lönnecke, Jens Pietzsch, Evamarie Hey-Hawkins   +8 more
wiley   +1 more source

Synthesis of Nano-α-Al2O3 for 99Mo Adsorbent

Atom Indonesia, 2018
The fission-product 99Mo, having a high specific activity, is commonly used in alumina-based 99Mo/99mTc generator. Due to the limitation on the use of fission-product 99Mo, an alternative route for 99Mo production, namely activation of natural molybdenum
K Kadarisman, S Sriyono, A Abidin, E. Lestari, M Marlina, I. Saptiama, H. Setiawan   +6 more
doaj   +1 more source

Heterometallic Coordination Compounds with Amino‐Acid Dithiocarbamate Ligands

European Journal of Inorganic Chemistry, EarlyView.
This comprehensive review surveys the synthesis, molecular structures, and properties of heterobimetallic coordination compounds with amino‐acid dithiocarbamate ligands (AA‐DTCs), important O,S‐ditopic ligands. Most of the known compounds form infinite assemblies of different dimensions rather than molecular entities in the solid state.
Phil Köhler
wiley   +1 more source

Preparation and Characterization of Zirconia Nanomaterial as a Molybdenum-99 Adsorbent

Atom Indonesia, 2017
The present study deals with the synthesis and characterization of ZrO2 nanomaterial which can be used as an adsorbent for Molybdenum-99 (99Mo). The adsorbent can potentially be utilized as the material for 99Mo/99mTc generator column.
M Marlina, E. Sarmini, H Herlina, S Sriyono, I. Saptiama, H. Setiawan, K Kadarisman   +6 more
doaj   +1 more source

A Comprehensive Evaluation of Analytical Method Parameters Critical to the Reliable Assessment of Therapeutic mRNA Integrity by Capillary Gel Electrophoresis

ELECTROPHORESIS, EarlyView.
ABSTRACT In recent years, messenger ribonucleic acid (mRNA)‐lipid nanoparticle (LNP) biotherapeutics have demonstrated significant promise in disease treatment and prevention given their rapidly modifiable production processes and considerable capacity to adapt to complex or low‐yielding proteins of interest.
Jessica P. Tran, Jun Gao, Casey Lansdell, Barry Lorbetskie, Michael J. W. Johnston, Lisheng Wang, Xuguang Li, Huixin Lu   +7 more
wiley   +1 more source

Scalability study on [133La]LaCl3 production with a focus on potential clinical applications

EJNMMI Radiopharmacy and Chemistry
Background In recent years, targeted alpha therapy has gained importance in the clinics, and in particular, the alpha-emitter 225Ac plays a fundamental role in this clinical development.
Santiago Andrés Brühlmann, Martin Walther, Magdalena Kerstin Blei, Constantin Mamat, Klaus Kopka, Robert Freudenberg, Martin Kreller   +6 more
doaj   +1 more source

Determination of Radiochemical Purity of 99mTc-DTPA Using One-System Method of Paper Chromatography [PDF]

Journal of Pure and Applied Chemistry Research, 2019
The more efficient and effective quality control techniques for 99mTc-DTPA are needed because 99mTc has a short half-life of around 6.0 hours. We have succeeded in developing a one-system of TLC for radiochemical purity testing system that is faster and ...
Maskur Maskur, Enny Lestari, Amal Rezka Putra, Dede Kurniasih, Endang Sarmini, Yayan Tahyan, Adang Hardi Gunawan, Arni Aries   +7 more
doaj  

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

International Journal of Cancer, EarlyView.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano, Tina Keshavarzian, Nadine Biernath, Annika Fendler, Maria de Santis, Joachim Weischenfeldt, Mathieu Lupien   +6 more
wiley   +1 more source

Advanced Optical Microscopic Imaging Techniques for Imaging Amyloid Beta and Deciphering Alzheimer's Disease Pathogenesis

iRADIOLOGY, EarlyView.
Summary of optical microscopic imaging methods in Alzheimer's Diseases (AD) research. In addition to conventional microscopic imaging, some super‐resolution and deep‐imaging imaging techniques have been developed and utilized in AD studies. ABSTRACT Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive decline in ...
Shiju Gu, Chongzhao Ran
wiley   +1 more source

Impacts of Inorganic Arsenic Exposure on Genetic Stability of Human Mesenchymal Stromal Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human mesenchymal stem/stromal cells (hMSCs) can differentiate into mesoderm‐type cells, making them suitable candidates for tissue repair therapies. However, their relatively low frequency in adult tissue necessitates ex vivo expansion prior to regenerative medicine applications, and therefore, long‐term hMSC genetic stability during ...
Marc A. Beal, Melanie Coughlan, Andrée Nunnikhoven, Reena Corbane, Cathy Cummings‐Lorbetskie, Andrea Rowan‐Carroll, Tanvi Sharma, Andrew Williams, Jessie R. Lavoie, Andrew Stalker, Asish Mohapatra, Matthew J. Meier   +11 more
wiley   +1 more source