Results 111 to 120 of about 6,328 (205)

Synthesis, Radiochemical Characterization, and Biodistribution of a 188Re Analogue of [131I]mIBG in a Neuroblastoma Xenograft Model

Journal of Labelled Compounds and Radiopharmaceuticals, Volume 69, Issue 3, March 2026.
A 188Re analogue of [131I]mIBG was synthesized in moderate yields using 188Re‐4 + 1 chemistry. In vitro studies using SK‐N‐SH neuroblastoma cell lines demonstrated that the compound exhibited affinity for norepinephrine transporters expressed on these cancer cells.
Navin Sakhare, Dheeraj Kumar, Soumen Das, Arpit Mitra, Shubhangi Mirapurkar, G. Rani, M. Sheela, Viju Chirayil, Bhabani Mohanty, Anupam Mathur, Madhava B. Mallia, Pradip Chaudhari   +11 more
wiley   +1 more source

The role of IAEA in the Development of Radiopharmaceutical Sciences with Focus on Alpha Emitters [PDF]

Journal of Medical Imaging and Radiation Sciences, 2019
Amirreza Jalilian, Joao Alberto Osso, Aruna Korde, Starovoitova Valeriia   +3 more
openaire   +1 more source

Companion Diagnostics in Clinical Therapy: Current Applications and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Companion diagnostics use biomarker‐based assays to stratify patients for precision therapies, improving outcomes while reducing ineffective treatment and side effects. This review summarizes the evolution, regulatory landscape, clinical applications, and technological platforms of CDx, highlighting their role in biomarker‐driven precision therapy.
Yuesong Wu, Rou Xue, Xiangwen Luo, Jiangnan Liao, Zongbo Zhang, Jinhai Deng, Teng Liu, Xin Li, Zhe‐Sheng Chen, Mingzhu Yin   +9 more
wiley   +1 more source

Contralateral Spread of Asymmetrical Tremor in Parkinson's Disease

Movement Disorders Clinical Practice, Volume 13, Issue 3, Page 702-710, March 2026.
Abstract Background Parkinsonian tremor usually starts asymmetrically. The mid‐term prognosis of this lateralized tremor is unknown, as is the development of tremor in the contralateral arm. Objective To investigate the occurrence of contralateral tremor in the Parkinson's Progression Marker Initiative database, with data available for 7 years ...
Jacopo Pasquini, Nicola Pavese, Roberto Ceravolo, Rick C. Helmich, Günther Deuschl   +4 more
wiley   +1 more source

Revisiting the segmentation threshold for Lu‐177 SPECT

Medical Physics, Volume 53, Issue 3, March 2026.
Abstract Background The mostly used threshold‐based segmentation method for SPECT, i.e., 42% of the maximum intensity, was derived from 99mTc and may not be directly applicable to 177Lu. Purpose This study aims to revisit the optimal segmentation threshold for 177Lu SPECT.
Yibin Liu, Jian Yang, Peng Wang, Yingwei Wang, Yue Chen, Greta S. P. Mok   +5 more
wiley   +1 more source

Bismuth Bicycles

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
Discovery, evolution and potential future applications of bismuth bicycle molecules—a novel class of therapeutics with unique properties. ABSTRACT Bicyclic peptides are emerging as next generation therapeutics by combining the affinity and specificity of antibodies with the synthetic convenience of small molecules.
Saan Voss, Amin Sagar, Arnaud Tiberghien, Richard J. L. Hughes, Liuhong Chen, Inmaculada Rioja, Mark Frigerio, Michael J. Skynner, David R. Spring   +8 more
wiley   +1 more source

Investigation of a Radio-Iodinated Alpha-Mangostin for Targeting Estrogen Receptor Alpha (ERα) in Breast Cancer: In Silico Design, Synthesis, and Biological Evaluation

Drug Design, Development and Therapy
Muchtaridi Muchtaridi,1,2 Wiwit Nurhidayah,1 Taufik Muhammad Fakih,1,3 Kento Kannaka,4 Hiroyuki Suzuki,4 Toto Subroto,5 Tomoya Uehara4 1Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang,
Muchtaridi M, Nurhidayah W, Fakih TM, Kannaka K, Suzuki H, Subroto T, Uehara T   +6 more
doaj  

Challenges in radiopharmaceutical importation across six Southern African Development Community countries: an exploratory study. [PDF]

Front Med (Lausanne)
Mkhombo VG, Mosima L, Summers B.
europepmc   +1 more source

Targeted β^--Particle Plus Conversion and Auger-Electron Therapy with ¹⁶¹Tb-Labeled Somatostatin Receptor Antagonist DOTA-LM3: A Phase 0 Study. [PDF]

J Nucl Med
Fricke JG, Westerbergh F, McDougall L, Favaretto C, Christ E, Nicolas GP, Geistlich S, Schmid DE, Borgna F, Fani M, Bernhardt P, van der Meulen NP, Müller C, Schibli R, Wild D.   +14 more
europepmc   +1 more source

Correction: Assessing the potential of bacterial signal peptides for radiopharmaceutical applications. [PDF]

Sci Rep
Al Taleb Z, Hierlmeier I, Heilmann H, Jung M, Bartholomä M, Bufe B.   +5 more
europepmc   +1 more source