Results 121 to 130 of about 12,450 (234)

Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors

Pediatric Blood &Cancer, Volume 73, Issue 5, May 2026.
ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy, Elizabeth L. Seashore, W. Susan Cheng, Shondra Clay, Jessica A. Casas, Jennifer H. Foster   +5 more
wiley   +1 more source

Trends in nuclear medicine and the radiopharmaceutical sciences in oncology

lancet oncology
Although the promise of radionuclides for the diagnosis and treatment of disease was recognised soon after the discovery of radioactivity in the late 19th century, the systematic use of radionuclides in medicine only gradually increased over the subsequent hundred years.
Scott, Andrew M., Zeglis, Brian M., Lapi, Suzanne E., Scott, Peter J. H., Windhorst, Albert D., Abdel-Wahab, May, Giammarile, Francesco, Piaez, Diana, Jalilian, Amirreza, Knoll, Peter, Korde, Aruna, Vichare, Shrikant, Ayati, Nayyereh, Lee, Sze Ting, Lyashchenko, Serge K., Zhang, Jingjing, Urbain, Jean Luc, Lewis, Jason S.   +17 more
openaire   +1 more source

Integrating polygenic and transcriptional risk scores for detecting Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Early detection of Alzheimer's disease (AD) is essential, yet existing biomarkers are invasive or costly. Polygenic risk scores (PRS) and transcriptional risk scores (TRS) may offer accessible alternatives, but their combined predictive performance remains understudied.
Jiyun Hwang, Jung‐Min Pyun, Joo‐Yeon Lee, Jeong Su Park, Paula J. Bice, Andrew J. Saykin, Joohon Sung, SangYun Kim, Young Ho Park, Kwangsik Nho, for the Alzheimer's Disease Neuroimaging Initiative   +10 more
wiley   +1 more source

Focal Spot, Summer/Fall 2008 [PDF]

, 2008
https://digitalcommons.wustl.edu/focal_spot_archives/1109/thumbnail ...

core   +1 more source

Usage and positivity rates of Alzheimer's disease biomarkers in a memory clinic

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Usage of biomarker tests for Alzheimer's disease pathology and rates of positivity were assessed at the Washington University Memory Diagnostic Center. METHODS Patients who underwent at least one biomarker test for clinical purposes between June 2021 and March 2025 were included (n = 1136). Data were retrospectively extracted from
Anna Hofmann, Benjamin Saef, William J. B. Powell, Madeline Paczynski, Maria R. Ponisio, Clara Vila‐Castelar, Zachary Posey, Inez Y. Oh, Mackenzie R. Hofford, Melissa Aldinger, Randall J. Bateman, Cyrus A. Raji, Tammie L. S. Benzinger, Carlos Cruchaga, Alan Dow, Rachel Buckley, Chengjie Xiong, John C. Morris, B. Joy Snider, Aditi Gupta, Suzanne E. Schindler   +20 more
wiley   +1 more source

When Does Alzheimer's Disease Start? Plasma Aβ42/40 Assays Show Steep Changes at Aβ‐PET Centiloid 15, Mean Age of 66 Years

Annals of Neurology, Volume 99, Issue 5, Page 1327-1342, May 2026.
Objective Sporadic late‐onset Alzheimer's disease (AD) is characterized by a long pre‐clinical phase where amyloid‐beta (Aβ) and tau begin to accumulate in the brain. The primary objective was to determine the age at which AD starts by finding the average population age when both positron emission tomography (PET) Aβ (Aβ‐PET) and plasma Aβ42/40 become ...
Rodrigo Cánovas, Timothy Cox, Vincent Doré, Pierrick Bourgeat, Jurgen Fripp, Azadeh Feizpour, Rosita Shishegar, Christopher J. Fowler, Simon M. Laws, Tenielle Porter, Stephanie Rainey‐Smith, Leslie M. Shaw, Randall J. Bateman, Yan Li, Ovod Vitaliy, Michael W. Weiner, John C. Morris, Tammie L.S. Benzinger, Suzanne E. Schindler, Akinori Nakamura, Takeshi Iwatsubo, Takeshi Ikeuchi, Takashi Kato, Paul Maruff, Hamid R. Sohrabi, Christopher C. Rowe, Ralph N. Martins, Colin L. Masters, James D. Doecke, for the Alzheimer's Disease Neuroimaging Initiative   +29 more
wiley   +1 more source

Positron Emission Tomography Imaging of Bacterial Infections With an Enterobactin Analog to Monitor Treatment Efficacy With a Catechol Antibiotic

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
Synopsis. The [68Ga]GaIII‐TREN‐CAM radiochelate selectively accumulates in Gram‐negative sites of infection and noninvasively monitors treatment response a siderophore antibiotic. ABSTRACT Positron emission tomography (PET) is an emerging tool under clinical investigation for the detection of bacterial infections.
M. Andrey Joaqui‐Joaqui, Phuong Nguyen Tran, Axia Marlin, Fiona Armstrong‐Pavlik, Minhua Cao, Valérie C. Pierre, Eszter Boros   +6 more
wiley   +2 more sources

Capability Development in the European Medicines Regulatory Network—A European Learning Needs Analysis and Survey Study

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1288-1297, May 2026.
The European Medicines Regulatory Network plays a critical role in safeguarding public health through the assessment and supervision of human medicines. However, rapid scientific and technological advancements have exposed capability deficits across the network, threatening timely and effective regulatory decision‐making.
Naomi Beard, Marko J. Kallio, Luca Kosec, Ulrika Espefält Westin, on behalf of the IncreaseNET consortium   +4 more
wiley   +1 more source

Evaluation of folate receptor-alpha and other surface markers as potential targets for radionuclide therapy of ovarian cancer

EJNMMI Research
Background Epithelial ovarian cancer (EOC) has the highest mortality rate among gynecological malignancies, primarily due to frequent late-stage diagnosis and the development of resistance to chemotherapy.
Benjamin D. Hunkeler, Jakob Heimer, Ana Katrina Mapanao, Matthias Choschzick, Cristina Müller, Niels J. Rupp   +5 more
doaj   +1 more source

Deep learning‐based H&E‐derived risk scores in colorectal cancer: associations with tumour morphology, biology, and predicted drug response

The Journal of Pathology, Volume 269, Issue 1, Page 112-124, May 2026.
Abstract Over recent years, several deep learning (DL) models have been presented to predict colorectal cancer (CRC) patient survival directly from haematoxylin and eosin (H&E)‐stained routine whole‐slide images (WSIs). Unlike traditional studies that rely on manually defined histopathological features, weakly supervised DL allows training directly on ...
Nic G Reitsam, Xiaofeng Jiang, Junhao Liang, Bianca Grosser, Veselin Grozdanov, Chiara ML Loeffler, Marco Gustav, Tim Lenz, Hannah S Muti, Zunamys I Carrero, Nicholas P West, Philip Quirke, Sebastian Foersch, Moritz Jesinghaus, Wolfram Müller, Tanwei Yuan, Michael Hoffmeister, Hermann Brenner, Jitendra Jonnagaddala, Nicholas J Hawkins, Robyn L Ward, Heike I Grabsch, Bruno Märkl, Jakob N Kather   +23 more
wiley   +1 more source