Results 51 to 60 of about 6,121 (195)

Brain Incidentalomas in Positron Emission Tomography: A Systematic Literature Review and Meta‐Analysis

Clinical Neuroimaging, Volume 3, Issue 1, 2026.
ABSTRACT Background and Purpose Over the past decades, whole‐body PET‐CT scanning has undergone considerable innovation, with a considerable increase in clinical indications becoming a key diagnostic imaging method. Subsequently PET is contributing to the growth in imaging incidentaloma rates, including those of the brain, a critical functional tissue.
Feras Chehade, Zainab Salman, Shorouk Hajeer, Joya Hadchiti, Jean ABI Ghosn, Linda Abou‐Abbas, Adam Bekkhoucha, Asaad Mohanna   +7 more
wiley   +1 more source

Design, Synthesis, and Selective Antiproliferative Activity of Indolizine Derivatives as Microtubule Destabilizers

Archiv der Pharmazie, Volume 358, Issue 12, December 2025.
A series of indolizine derivatives was synthesized and biologically evaluated. Compounds 8e and 8h showed nanomolar antiproliferative activity against cancer cells and low toxicity to normal cells. They act as microtubule‐destabilizing agents, inducing G2/M arrest and modulating key proteins. Docking confirmed binding at the colchicine site of tubulin.
Victor Hugo Catricala Fernandes, Maitê Bueno Giometti, Franco Jazon Caires, Gabriel de Paula Bueno, Gabriel da Silva, Andréia Machado Leopoldino, Anna Junker, Giuliano Cesar Clososki   +7 more
wiley   +1 more source

Guidance on validation and qualification of processes and operations involving radiopharmaceuticals

EJNMMI Radiopharmacy and Chemistry, 2017
Background Validation and qualification activities are nowadays an integral part of the day by day routine work in a radiopharmacy. This document is meant as an Appendix of Part B of the EANM “Guidelines on Good Radiopharmacy Practice (GRPP)” issued by ...
S. Todde, P. Kolenc Peitl, P. Elsinga, J. Koziorowski, V. Ferrari, E. M. Ocak, O. Hjelstuen, M. Patt, T. L. Mindt, M. Behe   +9 more
doaj   +1 more source

Opportunities and Challenges of the Application of Nuclear Magnetic Resonance‐Based Cerebrospinal Fluid Metabolomics for Clinical Research

Chemistry–Methods, Volume 5, Issue 12, November 2025.
Cerebrospinal fluid (CSF) is an important diagnostic matrix in neurology. This review illustrates the potentials and pitfalls of current CSF analysis by nuclear magnetic resonance. Created with BioRender.com in BioRender. Berezhnoy, G. (2025) https://BioRender.com/x80l903. Web of Science is owned by Clarivate.
Georgy Berezhnoy, Jannik Sprengel, Claire Cannet, Nils Pompe, Christoph Trautwein   +4 more
wiley   +1 more source

Selection of DNA Aptamers Against Parathyroid Hormone for Electrochemical Impedimetric Biosensor System Development

Biotechnology and Applied Biochemistry, Volume 72, Issue 5, Page 1351-1362, October 2025.
ABSTRACT This work presents the pioneering development of an aptamer‐based electrochemical biosensor for real‐time monitoring of parathyroid hormone (PTH) levels, with a focus on intraoperative assessment during parathyroid surgery. It introduces, for the first time, the selection and characterization of aptamers targeting distinct segments of the PTH ...
Reza Didarian, Saharnaz Bargh, Almina Gülerman, Veli Cengiz Özalp, Özcan Erel, Nimet Yildirim‐Tirgil   +5 more
wiley   +1 more source

Introducing bromine to the molecular structure as a strategy for drug design

Journal of Medical Science
Nowadays, the search for new pharmaceuticals has resulted in the development of thousands of new substances. One of the effective drug design strategies is to modify a previously obtained and studied substance.
Eduard Potapskyi, Karolina Kustrzyńska, Dawid Łażewski, Paulina Skupin-Mrugalska, Roman Lesyk, Marcin Wierzchowski   +5 more
doaj   +1 more source

Toward Stability Enhancement of NTS₁R-Targeted Radioligands: Structural Interventions on [^99mTc]Tc-DT1

Pharmaceutics, 2023
The neurotensin subtype 1 receptor (NTS1R) is overexpressed in a number of human tumors, thereby representing a valid target for cancer theranostics with radiolabeled neurotensin (NT) analogs like [99mTc]Tc-DT1 (DT1, N4-Gly7-NT(8-13)). Thus far, the fast
Panagiotis Kanellopoulos, Berthold A. Nock, Eric P. Krenning, Theodosia Maina   +3 more
doaj   +1 more source

Superparamagnetic Iron Oxide Tracer: A Magnetic Match to Gold Standard in Melanoma Sentinel Lymph Node Biopsy—A Systematic Review and Meta‐Analysis

Journal of Surgical Oncology, Volume 132, Issue 5, Page 860-868, October 2025.
ABSTRACT Superparamagnetic iron oxide (SPIO) tracer is a potential option for sentinel lymph node biopsy (SLNB), though its application in melanoma remains minimally explored. This systematic review evaluated the use of SPIO tracer compared to the standard approach for SLNB in melanoma.
Kadhim Taqi, Eva Lindell Jonsson, Golpira Elmi Assadzad, Cecily Stockley, Ish Bains, Claire Temple‐Oberle   +5 more
wiley   +1 more source

The effect of radiolabeled nanostructured lipid carrier systems containing imatinib mesylate on NIH-3T3 and CRL-1739 cells

Drug Delivery, 2020
The aim of current study is to develop new nanostructured lipid carrier systems (NLCSs) containing imatinib mesylate (IMT) and evaluate their targeting efficiency on NIH-3T3 as fibroblast cells and CRL-1739 as gastric adenocarcinoma cells with ...
Evren Atlihan Gundogdu, Emine Selin Demir, Meliha Ekinci, Emre Ozgenc, Derya Ilem Ozdemir, Zeynep Senyigit, Makbule Asikoglu   +6 more
doaj   +1 more source

Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice [PDF]

, 2017
Introduction : Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development.
De Lombaerde, Stef, De Vos, Filip, Devisscher, Lindsey, Kersemans, Ken, Neyt, Sara, Van Vlierberghe, Hans, Vanhove, Christian, Verhoeven, Jeroen   +7 more
core   +3 more sources