Results 61 to 70 of about 6,121 (195)

Development of Carborane‐Based Halogenated Naphthyridinone‐Analogues as Cannabinoid Receptor Type 2 (CB2R) Ligands

ChemMedChem, Volume 20, Issue 17, September 11, 2025.
There is no suitable radioligand for positron emission tomography imaging of CB2R overexpression for routine clinical usage. Herein, the synthesis, characterization, binding affinity, and docking studies of carborane‐based halo‐substituted naphthyridinone derivatives as CB2R ligands are presented.
Lea Ueberham, Winnie Deuther‐Conrad, Peter Lönnecke, Aleksandr Kazimir, Evamarie Hey‐Hawkins   +4 more
wiley   +1 more source

Emerging Radiopharmaceuticals Beyond FDG for Ovarian Cancer: A Review of Advances in Nuclear Medicine

Cancer Medicine, Volume 14, Issue 17, September 2025.
Emerging radiopharmaceuticals in nuclear medicine could improve ovarian cancer diagnosis and staging, while also enabling assessment of treatment response, therapy resistance, and suitability for targeted therapies. ABSTRACT Aims This review summarizes the role and future prospects of nuclear medicine in ovarian cancer, focusing on novel ...
Mara M. K. Veenstra, Sophie Veldhuijzen van Zanten, Erik Vegt, Ingrid A. Boere, Heleen J. van Beekhuizen, Julie Nonnekens, Frederik A. Verburg, Maarten G. J. Thomeer   +7 more
wiley   +1 more source

A pathway toward clinical translation of hyperpolarized [1,4‐13C2,2,3‐d2]fumarate as an imaging biomarker for early cellular necrosis in vivo

Magnetic Resonance in Medicine, Volume 94, Issue 3, Page 1202-1217, September 2025.
Abstract Purpose The detection of hyperpolarized carbon‐13 (HP 13C)‐fumarate conversion to 13C‐malate using 13C‐MRSI is a biomarker for early detection of cellular necrosis. Here, we describe the translation of HP 13C‐fumarate as a novel human imaging agent, including the evaluation of biocompatibility and scaling up of the hyperpolarization methods ...
Jonathan R. Birchall, Pascal Wodtke, Ashley Grimmer, Esben S. S. Hansen, Lotte B. Bertelsen, Nikolaj Bøgh, Marta Wylot, Maria J. Zamora‐Morales, Otso Arponen, Ines Horvat‐Menih, Elizabeth C. Latimer, Fung Tan, Evita Pappa, Johann Graggaber, Joseph Cheriyan, Kelly Holmes, Matthew J. Locke, Helen Sladen, Joan Boren, Mikko I. Kettunen, Anita Chhabra, Ian B. Wilkinson, Christoffer Laustsen, Kevin Brindle, Mary A. McLean, Ferdia A. Gallagher   +25 more
wiley   +1 more source

Radiopharmaceuticals drug interactions: a critical review

Anais da Academia Brasileira de Ciências, 2008
Radiopharmaceuticals play a critical role in modern medicine primarily for diagnostic purposes, but also for monitoring disease progression and response to treatment.
Ralph Santos-Oliveira, Sheila W. Smith, Ana Maria A. Carneiro-Leão   +2 more
doaj   +1 more source

Ga(III) chelates of amphiphilic DOTA-based ligands : synthetic route and in vitro and in vivo studies [PDF]

, 2011
In this work we report a synthetic strategy of amphiphilic DOTA-based chelators bearing a variable size α-alkyl chain at one of the pendant acetate arms (from six to fourteen carbon atoms), compatible with their covalent coupling to amine-bearing ...
André, João P., Fontes, André Filipe Gomes Soares, Geraldes, Carlos F. G. C., Prata, M. Isabel M.   +3 more
core   +1 more source

Imidazolium‐Based Lipid Analogs as Lipofection Reagents

Archiv der Pharmazie, Volume 358, Issue 8, August 2025.
Imidazolium‐based lipid analogs were synthesized and assessed for liposome‐mediated gene transfer. Cytotoxicity varied with alkyl chain saturation; di‐unsaturated analogs achieved effective transfection despite higher toxicity. These insights into the effects of lipid structure aid in designing efficient and safer nonviral delivery systems.
Marco Pierau, Ronewa Nematswerani, Calvin Dunker, Frank Glorius, Anna Junker   +4 more
wiley   +1 more source

PPoma Review: Epidemiology, Aetiopathogenesis, Prognosis and Treatment

Diseases, 2018
Generally, pancreatic polypeptide-secreting tumor of the distal pancreas (PPoma) is classified as a rare tumor, and may occur sporadically or be associated in families or with multiple endocrine neoplasia type 1 (NEM 1).
Thais Ligiero Braga, Ralph Santos-Oliveira   +1 more
doaj   +1 more source

Development and characterisation of improved unifocal primary mouse lung cancer models with metastatic potential

The Journal of Pathology, Volume 266, Issue 4-5, Page 405-420, August 2025.
Abstract Lung cancer is the leading cause of cancer‐related death globally. To better understand the biology of lung cancer, mouse models have been developed using either tail vein‐injected tumour cell lines or genetically modified mice. The current gold‐standard models typically present with multiple lung foci.
Ana‐Rita Pedrosa, Alejandro Castillo‐Kauil, Yuliia Kravchuk, Louise Reynolds, Bruce Williams, David Moore, Cameron Lang, Srinivas Allanki, Eleni Maniati, Alexandros Hardas, Jozafina Haj, Rebecca Drake, Julie Cleaver, Julie Foster, Jana Kim, Ester Stern, Jane Sosabowski, Gilbert O. Fruhwirth, Erik Sahai, Ori Wald, Kairbaan Hodivala‐Dilke   +20 more
wiley   +1 more source

The evolving role of positron emission tomography in precision prostate cancer biopsy

European Journal of Clinical Investigation, Volume 55, Issue 8, August 2025.
Prostate biopsy plays a pivotal role in the detection and characterization of prostate cancer. PSMA PET‐targeted biopsy represents a significant advancement in prostate cancer diagnostics, offering higher sensitivity, specificity and accuracy in detecting clinically significant lesions compared to traditional methods. PSMA PET, when combined with mpMRI,
Alessio Imperiale, Valentina Berti, Roberto Luigi Cazzato, Darejan Mamulashvili Bessac, Alice Ressault, Luca Vaggelli, Mehdi Helali, Camilo Garcia, Hervé Lang, Desirée Deandreis, Luc Mertz, Afshin Gangi   +11 more
wiley   +1 more source

GMP production of [18F]FE-PE2I on a TRACERLab FX2 N synthesis module, a radiotracer for in vivo PET imaging of the dopamine transport

EJNMMI Radiopharmacy and Chemistry
Background Parkinson's disease is a neurodegenerative disorder that is characterized by a degeneration of the dopaminergic system. Dopamine transporter (DAT) positron emission tomography (PET) imaging has emerged as a powerful and non-invasive method to ...
Mélodie Ferrat, Mohammad M. Moein, Carmen Cananau, Tetyana Tegnebratt, Paul Saliba, Fredrik Norman, Carsten Steiger, Klas Bratteby, Erik Samén, Kenneth Dahl, Thuy A. Tran   +10 more
doaj   +1 more source