Results 111 to 120 of about 7,625 (228)

Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update

, 2020
Cancer originates from genetic mutations accumulation. Cancer stem cells have been depicted as tumorigenic cells that can differentiate and self-renew. Cancer stem cells are thought to be resistant to conventional therapy like chemotherapy and radiation ...
Abdul Basit Ashraf, Gulshan Parveen, Arif Malik, Mahmood Husain Qazi, Sulayman Waquar, Misbah Sultana, Mahmood Rasool, Aamer Qazi   +7 more
core  

Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski, Mahima Raju, Tracy Fitzsimmons, Ishraq Murshed, Timothy J. Price, Michael Penniment, Sudarsha Selva‐Nayagam, Tarik Sammour   +7 more
wiley   +1 more source

Nimotuzumab Combined With Chemoradiotherapy in Head and Neck Squamous Cell Carcinoma and Nasopharyngeal Carcinoma: A Systematic Review and Meta‐Analysis

Asia-Pacific Journal of Clinical Oncology, EarlyView.
This meta‐analysis of 18 studies (3962 patients) demonstrates that nimotuzumab combined with chemoradiotherapy significantly improves overall survival and progression‐free survival in locally advanced head and neck squamous cell carcinoma, without increasing severe toxicity.
Chengzheng Bao, Yue Zhang, Xiang Fei, Kaifeng Ji, Ming Jia, Zhijun Li, Chao Bian   +6 more
wiley   +1 more source

Properties of some radiosensitizers studied by means of the electrochemical methods

, 2011
To determine the correlation between reduction potential and some physicochemical properties of selected radiosensitizers cyclic voltammetry and theoretical calculations based on the DFT method with B3LYP functional of the level of 6-311++G** basis set ...
Gál, Miroslav
core  

Musashi‐1 Drives Radioresistance and Stemness in Head and Neck Squamous Cell Carcinoma via a Radioresistant FaDu Model

Cancer Science, EarlyView.
Fractionated irradiation generated radioresistant F‐IRR cells with enhanced CSC properties despite slower proliferation. MSI1 was strongly upregulated and functionally promoted stemness, tumorigenicity, and radiation resistance. JNK signaling acted upstream of MSI1, while JNK inhibition suppressed these malignant traits, identifying the JNK–MSI1 axis ...
Na‐Eun Kang, Chan‐Woong Jung, Yun‐Ju Kim, Sung‐Gil Chi, Jeong‐Yub Kim, Myung‐Jin Park   +5 more
wiley   +1 more source

Psammaplin A-Modified Novel Radiosensitizers for Human Lung Cancer and Glioblastoma Cells

, 2019
Background: Psammaplin A (PsA) is a radiosensitizer whereas its clinical application is hampered by poor bioavailability. This study aimed to synthesize novel radiosensitizers using PsA as the lead compound.
Hyun-Cheol Kang, Wee, Chan Woo, Beom Soo Shin, Hak Jae Kim, Eunsook Ma, Jin Ho Kim, Soo Youn Suh, Il Han Kim   +7 more
core   +1 more source

Avian Eggshell Evolutionary Adaptations Inform Biomimetic Strategies for Next‑Generation Precision Cancer Theranostics

Advanced Oncology, Volume 1, Issue 1, December 2026.
ABSTRACT The avian eggshell is a sophisticated, multi‐functional biocomposite and, more importantly, an autonomous life‐support system evolved to safeguard embryonic development across dynamic and hostile environments. Discussing eggshell‐inspired biomaterials beyond simple structural imitation, this review translates these evolutionary survival ...
Zhiqiang Liu, Sida Ling, Mengqi Zhao, Chunyan Zhu, Yaoye Zhou, Hengquan Hou, Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Zuyong Wang, Swee Hin Teoh   +11 more
wiley   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, Volume 159, Issue 11, Page 2633-2652, 1 December 2026.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole Alkylsulfonamides

, 2018
Innovations in the field of radiotherapy such as stereotactic body radiotherapy, along with the advent of radio- immuno-oncology, herald new opportunities for classical oxygen-mimetic radiosensitizers.
Ralph J. Stevenson, Frederik B. Pruijn, Way Wua Wong, Robert F. Anderson, Qi, W, Stephen M. F. Jamieson, Muriel Bonnet, Wang, J, Bonnet, M, Lydia P. Liew, Kevin O. Hicks, Cho Rong Hong, Avik Shome, Wen Qi, Yongchuan Gu, Michael P. Hay, William R. Wilson, Jingli Wang, Hicks, KO, Liew, LP, Gu, Y, Wong, WW, Stevenson, RJ, Hay, MP, Anderson, RF, Wilson, WR, Hong, CR, Pruijn, FB, Jamieson, SMF, Shome, A   +29 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, Volume 38, Issue 61, 2 November 2026.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source