Results 121 to 130 of about 7,625 (228)

Ultrasmall Gold Nanoclusters Inhibit Colon Cancer Cell Growth

Aggregate, Volume 7, Issue 11, November 2026.
Ultrasmall Au25(p‐MBA)18 nanoclusters and larger gold nanoparticles functionalized with the same ligands exhibit contrasting cytotoxic effects across multiple colorectal cancer (CRC) cell lines. Scanning transmission electron microscopy enables visualization of the intracellular localization of Au25(p‐MBA)18 nanoclusters.
Qing Wang, Wenya Li, Qingyuan Li, Yingying Li, Yixia Chai, Changhua Wang, Xitong Zhang, Yitao Cao, Side Liu, Peng Zhang   +9 more
wiley   +1 more source

Computational advances in the design and discovery of artemis inhibitors for radiosensitization in cancer therapy

Frontiers in Chemistry
IntroductionArtemis is a key scaffold repair protein involved in the non-homologous end-joining (NHEJ) DNA repair pathway and is encoded by the DCLRE1C gene in humans.
Maryam Bashir, Usman Abdullah, Sadia Nazir, Farhan Siddique, Nasir Jalal   +4 more
doaj   +1 more source

Dissecting the Radioresponse Heterogeneity of Lung Adenocarcinoma Cells From the Perspective of Transcriptional and Regulatory Landscape

MedComm, Volume 7, Issue 11, November 2026.
Radiation‐associated transcriptional and regulatory cell states drive heterogeneous radioresponses in isogenic lung adenocarcinoma cells. ABSTRACT Radioresistance severely compromises radiotherapy efficacy for lung adenocarcinoma (LUAD), yet the intrinsic heterogeneity of cellular radioresponses among isogenic tumor cells remains poorly characterized ...
Huan Tao, Yaru Li, Leixin Ge, Lu Chen, Yang Zheng, Feiyue Ma, Changhui Ge, Hanjiang Fu, Yu Sun, Longteng Wang, Junting Wang, Xuemei Bai, Hao Li, Xiaochen Bo, Hebing Chen, Xiaofei Zheng   +15 more
wiley   +1 more source

Selenium‐Doped Nanoheterojunctions for Highly Efficient Cancer Radiosensitization

Advanced Science
Exploring efficient and low‐toxicity radiosensitizers to break through the bottleneck of radiation tolerance, immunosuppression and poor prognosis remains one of the critical developmental challenges in radiotherapy.
Rui Qiao, Zhongwen Yuan, Meijin Yang, Zhiying Tang, Lizhen He, Tianfeng Chen   +5 more
doaj   +1 more source

Neutrophil Extracellular Traps: From Mechanistic Insights to Therapeutic Targeting

MedComm, Volume 7, Issue 11, November 2026.
Neutrophil extracellular traps act as multimodal signal processors in cancer via three mechanisms: biomechanical scaffolds activating integrin–FAK signaling and excluding immune cells; immunometabolic hubs driving glycolysis and immunosuppression; and signal‐integration platforms synergistically activating oncogenic pathways.
Hongjie Fan, Yurui Tong, Bufu Tang, Jihong Hu, Xuefeng Kan, Bin Liang   +5 more
wiley   +1 more source

Topology and dynamics of the interaction between 5-nitroimidazole radiosensitizers and duplex DNA studied by a combination of docking, molecular dynamic simulations and NMR spectroscopy

, 2011
In spite of recent progress, cancer is still one of the most serious health problems of mankind. Recently, it has been discovered that tumor hypoxia can be exploited for selective anticancer treatment using radiosensitizers that are activated only under ...
Gonçalves, Arlan S., França, Tanos C. C., Cortopassi, Wilian A., Cunha, Elaine F. F. da, Silva, Alan W. S. da, Ramalho, Teodorico C.   +5 more
core  

Patient-Derived Organoids as a Platform to Decipher and Overcome Radioresistance: From the Tumor Microenvironment to Radiosensitizer Discovery

Current Oncology
Patient-derived organoids (PDOs) preserve patient genotypes and 3D architecture, offering a useful platform to investigate mechanisms of radioresistance and test radiosensitizers.
Dashan Yin, Xiujuan Hong, Xiaoqi Wang, Wenjia Ding, Chenli Wang, Jin Qian, Yi Zhou, Chuan Sun, Zhibing Wu   +8 more
doaj   +1 more source

Protein Lactylation in Cancer: From Mechanisms to Therapy

MedComm, Volume 7, Issue 11, November 2026.
Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Wentian Huang, Ping Hu, Shun Wang, Xide Zhang, Ziran Ye, Shengqiang Chen, Fu Gao, Yuanyuan Chen, Yanyong Yang   +8 more
wiley   +1 more source

Do malignant tumors need oxygen to survive radiotherapy?

Nowotwory
The pathological vascular network in malignant tumors is generally irregular and chaotic. Euoxic clonogenic tumor cells (radiosensitive) are gathered around the vessels, which are unevenly distributed within the tumor volume. The results of many clinical
Bogusław Maciejewski, Rafał Suwiński
doaj   +1 more source

Targeting the NR3C1‐ACSL4 Axis Triggers Ferroptosis to Overcome Radioresistance in Prostate Cancer

Cancer Science, Volume 117, Issue 11, Page 2953-2966, November 2026.
The glucocorticoid receptor NR3C1 drives prostate cancer radioresistance by upregulating ACSL4. High ACSL4 levels create a lipid metabolic vulnerability. The clinical agent DHA synergizes with ACSL4 to induce lipid peroxidation and ferroptosis, effectively overcoming radioresistance.
Jing Yang, Puyuan Chen, Yawen Zheng, Feiyue Shi, Min Wang, Luwei Xu, Xiaowei Wei, Xiumei Wang   +7 more
wiley   +1 more source