Results 81 to 90 of about 7,625 (228)
Radioresistance in Glioblastoma and the Development of Radiosensitizers
, 2020 Ionizing radiation is a common and effective therapeutic option for the treatment of glioblastoma (GBM). Unfortunately, some GBMs are relatively radioresistant and patients have worse outcomes after radiation treatment.
Douglas R. Spitz +9 more
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ClonoScreen3D : a novel three-dimensional clonogenic screening platform for identification of radiosensitizers for glioblastoma [PDF]
, 2023 Purpose Glioblastoma (GBM) is a lethal brain tumour. Standard of care treatment comprising surgery, radiation and chemotherapy results in median survival rates of 12-15 months.
R Richards, Amanda +6 more
core
Small StructuresInsufficient reactive oxygen species originating from hypoxia and high glutathione (GSH) in the tumor microenvironment (TME) is an important reason for radiotherapy (RT) resistance.
Yingwen Li +8 more
doaj +1 more source
BMEMat, EarlyView.Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen +9 more
wiley +1 more source
Development of novel radiosensitizers for cancer therapy
, 2002 The novel radiosensitizers for cancer therapy, which have some atoms with large X-ray absorption cross sections, were synthesized. The chemical and radiation (X-rays, W target, 100kVp) toxicities and the radiosensitivities to LS-180 human colon ...
Akamatsu, K, Yokoya, A
core
Nitroimidazole-based radiosensitizers: Effect of halogenation on X-ray driven fragmentation
Radiosensitizers are compounds that enhance the effectiveness of cancer radiotherapy by increasing the sensitivity of tumor cells to ionizing radiation.
core +1 more source
, 2022 Conventional cancer treatment is mainly based on the surgical removal of the tumor followed by radiotherapy and/or chemotherapy. When surgical removal is not possible, radiotherapy and, less often, chemotherapy is the only way to treat patients. However,
Tomasz Radzik +7 more
core +1 more source
Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality
BMEMat, EarlyView.Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim +9 more
wiley +1 more source
The Rational Design and Biological Mechanisms of Nanoradiosensitizers
Nanomaterials, 2020 Radiotherapy (RT) has been widely used for cancer treatment. However, the intrinsic drawbacks of RT, such as radiotoxicity in normal tissues and tumor radioresistance, promoted the development of radiosensitizers.
Hainan Sun, Xiaoling Wang, Shumei Zhai
doaj +1 more source
Recent Advances in Ionizing Radiation as a Nonequilibrium Chemical Field for Catalysis
Carbon and Hydrogen, EarlyView.Ionizing radiation acts as a nonequilibrium chemical field that generates reactive species and structural perturbations. These radiation‐induced effects bridge catalytic material construction, including metal loading, framework evolution, defect engineering, and carbon‐network reorganization, with selective transformations such as oxidation, reduction,
Junhua Kuang +8 more
wiley +1 more source