Radiosynthesis of [18F]Trifluoroalkyl Groups: Scope and Limitations [PDF]
BioMed Research International, 2014 The present paper is concerned with radiochemical methodology to furnish the trifluoromethyl motif labelled with18F. Literature spanning the last four decades is comprehensively reviewed and radiochemical yields and specific activities are discussed.
Lien, V. T., Riss, P. J.
openaire +2 more sources
An Unexpected Facet of Extremophiles: Their Aesthetic Potential in Artistic Expression
Microbial Biotechnology, Volume 18, Issue 10, October 2025.In an era marked by environmental challenges and the proliferation of misinformation, the fusion of art and science is a strategy to promote public understanding and appreciation of complex scientific phenomena. We illustrate how the use of extremophiles offers novel avenues for artistic exploration and emphasise the benefits of such interdisciplinary ...
Luis Andrés Yarzábal Rodríguez +4 more
wiley +1 more source
Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production. [PDF]
, 2018 The development of new positron-emission tomography (PET) tracers is enabling researchers and clinicians to image an increasingly wide array of biological targets and processes.
Collins, Jeffrey +5 more
core
Synthesis of [11C]MK-1064 as a new PET radioligand for imaging of orexin-2 receptor [PDF]
, 2016 The reference standard MK-1064 {5″-chloro-N-((5,6-dimethoxypyridin-2-yl)methyl)-[2,2′:5′,3″-terpyridine]-3′-carboxamide} was synthesized from methyl 2-chloro-5-iodonicotinate and 5-(chloropyridin-3-yl)boronic acid in 4 steps with 33% overall chemical ...
Gao, Mingzhang +2 more
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Automated radiosynthesis and in vivo evaluation of 18F-labeled analog of the photosensitizer ADPM06 for planning photodynamic therapy [PDF]
, 2023 Kazunori Kawamura +10 more
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ChemMedChem, Volume 20, Issue 17, September 11, 2025.Fluorinated pyrazolidine‐3,5‐dione derivatives are developed with the aim to find a positron emission tomography (PET) tracer candidate for imaging of the P2Y12 receptor. All compounds show nanomolar affinity. One compound is radiolabeled with 18F and used in PET imaging studies, revealing rapid metabolism and limited brain uptake.
E. Johanna L. Stéen +11 more
wiley +1 more source
Imaging Microglial/Macrophage Activation in Spinal Cords of Experimental Autoimmune Encephalomyelitis Rats by Positron Emission Tomography Using the Mitochondrial 18kDa Translocator Protein Radioligand [18F]DPA-714 [PDF]
, 2012 Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Activated microglia/macrophages play a key role in the immunopathogenesis of MS and its corresponding animal models, experimental autoimmune encephalomyelitis (EAE).
Abourbeh, Galith +8 more
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Imaging microtubule dynamics: A new frontier in biomarker development for neurodegenerative diseases
Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.Abstract Microtubules (MTs) are essential components of the neuronal cytoskeleton, playing key roles in intracellular transport, synaptic function, and overall neuronal integrity. Although MT dynamics and MT‐binding agents have been studied extensively, their potential as biomarkers in neurodegenerative diseases has received limited attention. Emerging
Naresh Damuka +2 more
wiley +1 more source
Frontiers in ChemistryGallium-68-labeled FAPI-46 has recently been proposed as a novel positron emission tomography imaging probe to diagnose and monitor a wide variety of cancers.
Louis-Paul Paty +13 more
doaj +1 more source
Synthesis of [11C]GSK1482160 as a new PET agent for targeting P2X7 receptor [PDF]
, 2015 The authentic standards GSK1482160 and its isomer, as well as the radiolabeling precursors desmethyl-GSK1482160 and Boc-protected desmethyl-GSK1482160 were synthesized from l-pyroglutamic acid, methyl l-pyroglutamate and 2-chloro-3-(trifluoromethyl ...
Gao, Mingzhang +4 more
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