Polygalae Radix shortens the circadian period through activation of the CaMKII pathway
Pharmaceutical Biology, 2022 Context The mammalian circadian clock system regulates physiological function. Crude drugs, containing Polygalae Radix, and Kampō, combining multiple crude drugs, have been used to treat various diseases, but few studies have focussed on the circadian ...
Atsushi Haraguchi +3 more
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Polygalae Radix: Review of Metabolites, Pharmacological Activities and Toxicology
Frontiers in PharmacologyPolygalae Radix: is the dried root of Polygala tenuifolia Willd. or Polygala sibirica L., which has the effect of improving memory and cognitive function in traditional Chinese medicine.
Meihua Liu, Xin Wang, Dejiang Gao
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Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments. [PDF]
PLoS ONE, 2016 Decline of cognitive function is the hallmark of Alzheimer's disease (AD), regardless of the pathological mechanism. Traditional Chinese medicine has been used to combat cognitive impairments and has been shown to improve learning and memory.
Xiaohang Li +10 more
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Onjisaponin B Derived From Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant α-Synuclein and Huntingtin in PC-12 Cells [PDF]
International Journal of Molecular Sciences, 2013 Emerging evidence indicates important protective roles being played by autophagy in neurodegenerative disorders through clearance of aggregate-prone or mutant proteins.
Vincent Kam Wai Wong +2 more
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Journal of Pharmacological Sciences, 2016 Polygalae Radix is an important medicinal plant that is widely used in most of Africa. 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix.
Chang-Yuan Chen +2 more
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MS‐based multi‐dimensional metabolomics reveals protective effect of Polygalae Radix against metabolic disturbances in Alzheimer's disease mice [PDF]
Clinical and Translational MedicineClinical and Translational Medicine, Volume 15, Issue 4, April 2025.
Yanwen Chen +5 more
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Frontiers in Pharmacology, 2017 Memory impairments in Alzheimer’s disease (AD) occur due to degenerated axons and disrupted neural networks. Since only limited recovery is possible after the destruction of neural networks, preventing axonal degeneration during the early stages of ...
Tomoharu Kuboyama +4 more
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UPLC/Q-TOF MS-based metabolomics and qRT-PCR in enzyme gene screening with key role in triterpenoid saponin biosynthesis of Polygala tenuifolia. [PDF]
PLoS ONE, 2014 BackgroundThe dried root of Polygala tenuifolia, named Radix Polygalae, is a well-known traditional Chinese medicine. Triterpenoid saponins are some of the most important components of Radix Polygalae extracts and are widely studied because of their ...
Fusheng Zhang +6 more
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Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits. [PDF]
PLoS ONE, 2014 Alzheimer's disease (AD) is a progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe disease-modifying treatment and symptomatic intervention alternatives ...
Yujun Hou +12 more
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Analysis of Polygala tenuifolia Transcriptome and Description of Secondary Metabolite Biosynthetic Pathways by Illumina Sequencing [PDF]
International Journal of Genomics, 2015 Radix polygalae, the dried roots of Polygala tenuifolia and P. sibirica, is one of the most well-known traditional Chinese medicinal plants. Radix polygalae contains various saponins, xanthones, and oligosaccharide esters and these compounds are ...
Hongling Tian +6 more
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