Investigation of Marine-Derived Natural Products as Raf Kinase Inhibitory Protein (RKIP)-Binding Ligands [PDF]
Marine Drugs, 2021 Raf kinase inhibitory protein (RKIP) is an essential regulator of the Ras/Raf-1/MEK/ERK signaling cascade and functions by directly interacting with the Raf-1 kinase.
Shraddha Parate +3 more
doaj +2 more sources
Exploring the Binding Interaction of Raf Kinase Inhibitory Protein With the N-Terminal of C-Raf Through Molecular Docking and Molecular Dynamics Simulation [PDF]
Frontiers in Molecular Biosciences, 2021 Protein-protein interactions are indispensable physiological processes regulating several biological functions. Despite the availability of structural information on protein-protein complexes, deciphering their complex topology remains an outstanding ...
Shraddha Parate +4 more
doaj +2 more sources
Regulation on tumor metastasis by Raf kinase inhibitory protein: New insight with reactive oxygen species signaling [PDF]
Tzu Chi Medical Journal, 2021 Targeted therapy aiming at the metastatic signal pathway, such as that triggered by receptor tyrosine kinase (RTK), for the prevention of tumor progression is promising.
Chi-Tan Hu +2 more
doaj +2 more sources
A new model for raf kinase inhibitory protein induced chemotherapeutic resistance. [PDF]
PLoS ONE, 2012 Therapeutic resistance remains the most challenging aspect of treating cancer. Raf kinase inhibitory protein (RKIP) emerged as a molecule capable of sensitizing cancerous cells to radio- and chemotherapy.
Fahd Al-Mulla +4 more
doaj +2 more sources
cis-Acting elements and trans-acting factors in the transcriptional regulation of raf kinase inhibitory protein expression. [PDF]
PLoS ONE, 2013 The Raf kinase inhibitory protein (RKIP) is down-regulated in multiple types of human cancers. Decreased RKIP transcription activity may be one of the major mechanisms responsible for the downregulation of RKIP expression in human diseases.
Boyan Zhang +8 more
doaj +2 more sources
Biomolecules, 2023 Raf-1, a multifunctional kinase, regulates various cellular processes, including cell proliferation, apoptosis, and migration, by phosphorylating MAPK/ERK kinase and interacting with specific kinases.
Jason A. Kirkbride +7 more
doaj +1 more source
Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration. [PDF]
PLoS ONE, 2009 Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signaling by the Raf/MAP kinase pathway.
Anne N Shemon +8 more
doaj +1 more source
The many-faced KSR1: a tumor suppressor in breast cancer [PDF]
, 2015 Emerging evidence supports the dual function of kinase suppressor of Ras 1 (KSR1) as an active kinase and a scaffold, although it has been extensively referred as a pseudokinase, due to the absence of key residues in its catalytic domain [1, 2].
Giamas, Georgios +2 more
core +7 more sources
Inhibition of MLC phosphorylation restricts replication of influenza virus--a mechanism of action for anti-influenza agents. [PDF]
PLoS ONE, 2011 Influenza A viruses are a severe threat worldwide, causing large epidemics that kill thousands every year. Prevention of influenza infection is complicated by continuous viral antigenic changes.
Mehran Haidari +4 more
doaj +1 more source
Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death
Redox Biology, 2022 Ferroptosis and necroptosis are two pro-inflammatory cell death programs contributing to major pathologies and their inhibition has gained attention to treat a wide range of disease states.
Andrew M. Lamade +27 more
doaj +1 more source