Results 151 to 160 of about 60,399 (263)

Precision medicine in cutaneous melanoma—A comprehensive review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Precision medicine tailors treatment to each patient, beginning with detailed diagnostics. In melanoma, it has advanced considerably: Some methods are in practice and guidelines, while others are commercially available but not routine. This review highlights current and emerging approaches, including molecular profiling, imaging, biomarkers and AI ...
Markus Reitmajer, Lukas Flatz
wiley   +1 more source

The maize mitogen‐activated protein kinase kinase kinase gene ZmMAPKKK45 is associated with multiple disease resistance

New Phytologist, EarlyView.
Summary Southern leaf blight (SLB), caused by the necrotrophic fungus Cochliobolus heterostrophus, is a major foliar disease of maize (Zea mays) world‐wide. A genome‐wide association study was performed to dissect the genetic basis of SLB resistance in maize. Functional validation was performed using mutant and transgenic analyses.
Tao Zhong, Bode Olukolu, Yang Bian, Shang Xue, Randall J. Wisser, Peter S. Ojiambo, James B. Holland, Qin Yang, Peter Balint‐Kurti   +8 more
wiley   +1 more source

MITOGEN‐ACTIVATED PROTEIN KINASE9 fine‐tunes hypoxia signaling by phosphorylating ERF‐VII transcription factors in Arabidopsis

New Phytologist, EarlyView.
Summary In plants, hypoxia sensing is controlled by the stabilization of group VII ethylene response factors (ERF‐VIIs), which are post‐translationally activated by the mitogen‐activated protein kinases (MAPKs) MPK3 and MPK6. However, how plants fine‐tune the MPK3/MPK6‐mediated phosphorylation of ERF‐VIIs to maintain cellular homeostasis remains ...
De‐Mian Zhou, Ying Zhou, Xu‐Chen Wu, Qing‐Ying Ke, Tian‐Yi Zhang, Zi‐Yuan Yin, Li‐Li Shi, Ke Liao, Shi Xiao, Qin‐Fang Chen   +9 more
wiley   +1 more source

Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development. [PDF]

, 2019
Pancreatic ductal adenocarcinoma (PDAC) remains a deadly disease with no efficacious treatment options. PDAC incidence is projected to increase, which may be caused at least partially by the obesity epidemic.
Eibl, Guido, Rozengurt, Enrique
core  

USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies

Annals of the New York Academy of Sciences, EarlyView.
USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge, Hongying Sun, Jia Zhang, Yang Yang, Jian Mao, Cheliger   +5 more
wiley   +1 more source

EBSn, a Robust Synthetic Reporter for Monitoring Ethylene Responses in Plants

Plant Biotechnology Journal, EarlyView.
ABSTRACT Ethylene is a gaseous plant hormone that controls a wide array of physiologically relevant processes, including plant responses to biotic and abiotic stress, and induces ripening in climacteric fruits. To monitor ethylene in plants, analytical methods, phenotypic assays, gene expression analysis and transcriptional or translational reporters ...
Josefina‐Patricia Fernandez‐Moreno, Mario Fenech, Anna E. Yaschenko, Chengsong Zhao, Matthew Neubauer, Hannah N. Davis, Alex J. Marchi, Raine Concannon, Alexandra Keren‐Keiserman, Moshe Reuveni, Victor Levitsky, Dmitry Oshchepkov, Vladislav Dolgikh, Alexander Goldshmidt, José T. Ascencio‐Ibáñez, Elena Zemlyanskaya, Jose M. Alonso, Anna N. Stepanova   +17 more
wiley   +1 more source

The ZmFKF1b‐ZmDi19‐5 Regulatory Module Coordinates Drought Tolerance and Flowering Time in Maize

Plant Biotechnology Journal, EarlyView.
ABSTRACT Drought is a major environmental stress that inhibits plant growth and reduces crop yields. The Di19 gene family is known to play a pivotal role in mediating plant responses to drought. However, the mechanisms by which Di19 proteins integrate drought response with developmental processes, particularly flowering time, remain largely unknown in ...
Haixia Zeng, Dandan Dou, Yang Yang, Yan Yan, Yawen Sun, Shuhan Yang, Wen Yao, Shifang Zhao, Mingle Wang, Zhixue Liu, Zhenzhen Ren, Huihui Su, Liru Cao, Lixia Ku, Xu Zheng, Chengwei Li, Yanhui Chen   +16 more
wiley   +1 more source

The miR164b‐SiNAC015 Module Regulates Drought Tolerance by Scavenging Reactive Oxygen Species in Foxtail Millet

Plant Biotechnology Journal, EarlyView.
ABSTRACT Drought is the major abiotic stress threatening global crop yields, thus identifying potential candidates with promising breeding value has become a central goal of current breeding programmes. Here, we found that miR164b functions as a negative regulator in plant drought tolerance, whose expression is dramatically inhibited under drought ...
Tong Xiao, Liang Ma, Yifan Zhang, Linlin Zhang, Shixin Song, Xianmin Diao, Jingjuan Yu   +6 more
wiley   +1 more source

An Auto‐Activated NLR‐Protein OsRGA3D605V Confers Rice Triple Resistance and Deactivates Resistance After Phosphorylation by OsILA1

Plant Biotechnology Journal, EarlyView.
ABSTRACT The incidence of pests and diseases seriously impacts rice production, and NLR genes play a crucial role in the regulation of immune signalling in rice. Here, we identified an NLR gene OsRGA3 that positively regulates rice resistance to brown planthopper (BPH) and rice blast disease (RBD).
Yuan Zhong, Su Chen, Bo Sun, Min Liu, Zhenying Shi, Xuexia Miao, Haichao Li   +6 more
wiley   +1 more source

RAF Kinase Inhibitory Protein Expression and Phosphorylation Profiles in Oral Cancers.

Clinics in surgery
Raf Kinase Inhibitory Protein (RKIP) expression has been profiled for a number of unique tissue cancers. However, certain tissues have not been explored, and oral and oropharyngeal cancers stand out as high priority targets, given their relatively high incidence, high morbidity rate, and in many cases, preventable nature.
D P, Hallums, R, Gomez, A P, Doyle, C T, Viet, B L, Schmidt, N A, Jeske   +5 more
openaire   +1 more source