Results 161 to 170 of about 4,270,323 (214)

RAF isoform selectivity of MEK inhibitors and rational design of a covalent ARAF-MEK inhibitor. [PDF]

Sci Adv
Chakraborty S, Jiang J, Camallonga JV, Gazgalis D, Gero TW, Tavares MT, Dittemore G, Tkacik E, Beyett TS, Jang DM, Ha BH, Gottlieb FH, Levitz T, Metivier RJ, Schmoker AM, Scott DA, Jeon H, Jänne PA, Eck MJ.   +18 more
europepmc   +1 more source

Langerhans cell histiocytosis: molecular mechanisms underlying pathogenesis and emerging targeted therapeutics. [PDF]

Cancer Metastasis Rev
Li Q, Hu J.
europepmc   +1 more source

Raf kinase inhibitory protein (RKIP) as a metastasis suppressor: regulation of signaling networks in cancer. [PDF]

Crit Rev Oncog, 2014
Yesilkanal AE, Rosner MR.
europepmc   +1 more source

Dermatologic Toxicities Associated With Novel Pan‐RAS/RAF Inhibitors

Journal of Cutaneous Pathology, Volume 53, Issue 11, Page 1042-1050, November 2026.
ABSTRACT Background The mitogen‐activated protein kinase (MAPK) pathway plays a key role in cell‐cycle regulation and tumor progression in cancer. Dermatologic toxicities (DTs) to newer pan‐RAS (RMC‐6236) and pan‐RAF (LXH254/naporafenib) inhibitors are emerging.
Lin J. He, Shaymaa Hegazy, Phyu P. Aung, Priyadharsini Nagarajan, Fiorinda Muhaj, Adrienne N. Choksi, Ana M. Ciurea, Kelly C. Nelson, Doina Ivan, Carlos A. Torres‐Cabala, Victor G. Prieto, Jonathan L. Curry   +11 more
wiley   +1 more source

A‑Raf: A serine/threonine protein kinase with important biological functions (Review). [PDF]

Mol Med Rep
Yang M, Chen M, Wei J, Li Y, Long C, Lei Y, Zhou Y.   +6 more
europepmc   +1 more source

4‐1BBL Suppresses Anti‐Inflammatory Responses by Regulating Metabolic Reprogramming of Macrophages

Immunology, Volume 179, Issue 3, Page 434-443, November 2026.
4‐1BB ligand (4‐1BBL) is known to promote sustained pro‐inflammatory responses in macrophages. This study demonstrates that 4‐1BBL acts as a negative regulator of anti‐inflammatory macrophage responses. Genetic deletion or pharmacological inhibition of 4‐1BBL significantly enhanced the phosphorylation of IL‐4R‐proximal JAK1 and STAT6, elevating the ...
Young Jun Kang
wiley   +1 more source

The cross-talk between GSK-3β, RKIP, and PTEN as potential targets for therapeutic implications in cancer: a comprehensive insight. [PDF]

J Pharm Pharm Sci
Mosalam EM, Abdallah MS, Gardouh AR, Hamza E, Bahaa MM, Nazih M, Al-Dhelaan RA, Kamal N.   +7 more
europepmc   +1 more source

Diethylene Glycol‐Linked Ring‐Fused Bis‐Azoles: Target‐Oriented Synthesis, In Silico Screening, and Antitumor Activity

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Sami A. Al‐Hussain, Abdulrahman S. Alharbi, Zeinab A. Muhammad, Alyaa S. Abdel Halim, Magdi E. A. Zaki, Mark C. Bagley, Refaie M. Kassab   +6 more
wiley   +1 more source

Kinase cascades: emerging design principles and guidelines. [PDF]

RSC Chem Biol
Nussinov R, Regev C, Jang H.
europepmc   +1 more source