Results 181 to 190 of about 60,399 (263)

Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton, Nur Jury‐Garfe, Jiahui Liu, Caleb Beimfohr, Chitra Sunil, Steven Brooks, Pengyue Zhang, Sean D. McCabe, Timothy I. Richardson, Kun Huang, Cristian A. Lasagna‐Reeves, Jie Zhang, Travis S. Johnson   +12 more
wiley   +1 more source

The BRAF-specific region suppresses cysteine-rich domain-lipid interaction independently of canonical autoinhibition by the 14-3-3 dimer. [PDF]

Protein Sci
Revazishvili V, Morales A, Baxter B, Grim J, Chakhrakia A, Jimenez Salinas A, Tevdorashvili K, Riestra AM, Lee YK.   +8 more
europepmc   +1 more source

Prognostic value of phosphorylated Raf kinase inhibitory protein at serine 153 and its predictive effect on the clinical response to radiotherapy in nasopharyngeal carcinoma. [PDF]

Radiat Oncol, 2016
Li S, Liu T, Mo W, Hou Q, Zhou Y, Liu M, He Z, Liu Z, Chen Q, Wang H, Guo X, Xia W, Zeng M, Zhao H.   +13 more
europepmc   +1 more source

Anticancer Molecular Mechanisms of Curcuminoids: An Updated Review of Clinical Trials

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Curcuminoids remain one of the most studied dietary polyphenols as a cancer prevention and treatment agent. Inflammation and tumor progression are related to the NF‐κB signaling pathway, which is also suppressed by curcuminoids. Curcuminoids prevent the activation of a variety of signaling pathways, including the MAPK, PI3K/Akt, and NF‐kB pathways ...
Ushna Momal, Muhammad Shahbaz, Asfa Perween, Muhammad Hammad ul Hassan, Hammad Naeem, Zubda Shahid, Muzzamal Hussain, Muhammad Imran, Suliman A. Alsagaby, Waleed Al Abdulmonem, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Tadesse FentaYehuala, Samy Selim, Ehab M. Mostafa   +14 more
wiley   +1 more source

Unveiling a BRAF Signature Proficient in Accurately Capturing Oncogenic Activity and Guiding Prognostic Prediction Across Multiple Cancers

MedComm, Volume 7, Issue 2, February 2026.
The BRAF25 meta‐signature effectively captures BRAF‐driven oncogenic activity. By enabling precise patient stratification with distinct mutation profiles, BRAF25 identifies BRAF‐active tumor subtypes and provides superior prognostic value compared with mutation status alone.
Kaidi Yang, Shihui Fu, Jingbing Liang, Lijuan Ding, Junhao You, Fang Li, Ye Yuan, Xiu‐Wu Bian   +7 more
wiley   +1 more source

Triple HER2 Blockade With Trastuzumab, Pertuzumab, and Pyrotinib Versus Dual HER2 Blockade in the Neoadjuvant Treatment of HER2‐Positive Breast Cancer: A Randomized, Phase II Study

MedComm, Volume 7, Issue 2, February 2026.
Triple HER2 blockade with trastuzumab, pertuzumab, and pyrotinib (TPPy) did not improve total pathological complete response (tpCR) rates or breast pathological complete response (bpCR) rates compared with dual blockade with trastuzumab and pertuzumab (TP), but was associated with greater grade ≥ 3 toxicity, particularly diarrhea.
Jiahui Huang, Haoyu Wang, Yiwei Tong, Jin Hong, Yifei Zhu, Weili Ren, Jing Yu, Haoting Shi, Weiqi Gao, Siji Zhu, Jiayi Wu, Ou Huang, Jing Li, Jianrong He, Weiguo Chen, Yafen Li, Kunwei Shen, Xiaosong Chen   +17 more
wiley   +1 more source

Host Oxidative Response Capacity Determines Longevity Outcomes of Microbial Interventions

Aging Cell, Volume 25, Issue 2, February 2026.
Genetic variation determines whether microbial interactions extend or shorten host lifespan via redox homeostasis. This discovery highlights the critical role of host genetics in shaping microbiota‐driven aging, offering a new framework for precision microbiome interventions tailored to individual needs for promoting longevity.
Xusheng Hao, Rongwei Yuan, Yafei Guo, Guanyu Chen, Yongqing Guo, Limeng Liu, Fei Lu, Yang Bai, Ye Tian   +8 more
wiley   +1 more source

Reprogramming the Apoptosis-Autophagy Axis in Glioblastoma: The Central Role of the Bcl-2:Beclin-1 Complex and Survival Signalling Networks. [PDF]

Cells
Christoff M, Szczepańska A, Jakubowicz-Gil J, Zając A.   +3 more
europepmc   +1 more source

Survival of metastatic melanoma patients after dendritic cell vaccination correlates with expression of leukocyte phosphatidylethanolamine-binding protein 1/Raf kinase inhibitory protein. [PDF]

Oncotarget, 2017
Buschow SI, Ramazzotti M, Reinieren-Beeren IMJ, Heinzerling LM, Westdorp H, Stefanini I, Beltrame L, Hato SV, Ellebaek E, Gross S, Nguyen VA, Weinlich G, Ragoussis J, Baban D, Schuler-Thurner B, Svane IM, Romani N, Austyn JM, De Vries IJM, Schuler G, Cavalieri D, Figdor CG.   +21 more
europepmc   +1 more source

Crucial Contribution of BACH1 to Bladder Cancer Progression via Upregulating Epithelial‐Mesenchymal Transition Pathway

Cancer Science, Volume 117, Issue 2, Page 364-376, February 2026.
BACH1 is associated with poor prognosis in BC patients and plays a critical role in promoting tumor progression and metastasis. Furthermore, we elucidated the mechanism by which BACH1 facilitates tumor progression and metastasis, primarily through activation of the EMT pathway. These findings suggest that BACH1 may serve as a novel prognostic biomarker
Tomoya Hatayama, Kenshiro Takemoto, Kohei Kobatake, Kento Miura, Liyanage P. Perera, Ryoken Yamanaka, Kazuma Yukihiro, Hiroyuki Shikuma, Kyosuke Iwane, Ryo Tasaka, Yuki Kohada, Miki Naito, Shunsuke Miyamoto, Yohei Sekino, Hiroyuki Kitano, Keisuke Goto, Akihiro Goriki, Keisuke Hieda, Osamu Kaminuma, Nobuyuki Hinata   +19 more
wiley   +1 more source