Expression and Significance of Raf Kinase Inhibitory Protein in Lung Cancer
Chinese Journal of Lung Cancer, 2012 Background and objective Raf kinase inhibitory protein (RKIP) belongs to the phosphatidylethanolamine binding protein family. RKIP is an endogenous inhibitor of the ERK/MAPK, NF-κΒ, and G protein-coupled receptor signaling pathways.
Dayun YANG, Zhan QI
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MAP kinase meets mitosis: A role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation
Cell Division, 2007 Raf Kinase Inhibitory Protein (RKIP) is an evolutionarily conserved protein that functions as a modulator of signaling by the MAP kinase cascade.
Rosner Marsha
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Raf kinase inhibitory protein reduces bradykinin receptor desensitization. [PDF]
J Neurochem, 2022 AbstractInflammatory hyperalgesia represents a nociceptive phenotype that can become persistent in nature through dynamic protein modifications. However, a large gap in knowledge exists concerning how the integration of intracellular signaling molecules coordinates a persistent inflammatory phenotype.
Chivers SB, Brackley AD, Jeske NA.
europepmc +3 more sources
Raf Kinase Inhibitory Protein Down-Expression Exacerbates Hepatic Fibrosis In Vivo and In Vitro [PDF]
Cellular Physiology and Biochemistry, 2016 Background/Aims: Raf kinase inhibitory protein (RKIP) is closely associated with numerous tumors and participates in their development through regulating the growth, apoptosis, invasion and metastasis of tumor cells.
Quanfang Huang +8 more
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Transcriptional Repression of Raf Kinase Inhibitory Protein Gene by Metadherin during Cancer Progression. [PDF]
Int J Mol Sci, 2021 Raf kinase inhibitory protein (RKIP), also known as a phosphatidylethanolamine-binding protein 1 (PEBP1), functions as a tumor suppressor and regulates several signaling pathways, including ERK and NF-κκB. RKIP is severely downregulated in human malignant cancers, indicating a functional association with cancer metastasis and poor prognosis.
Lai TH +7 more
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Targeting Raf Kinase Inhibitory Protein Regulation and Function. [PDF]
Cancers (Basel), 2018 Raf Kinase Inhibitory Protein (RKIP) is a highly conserved kinase inhibitor that functions as a metastasis suppressor in a variety of cancers. Since RKIP can reprogram tumor cells to a non-metastatic state by rewiring kinase networks, elucidating the mechanism by which RKIP acts not only reveals molecular mechanisms that regulate metastasis, but also ...
Yesilkanal AE, Rosner MR.
europepmc +4 more sources
Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop. [PDF]
Proc Natl Acad Sci U S A, 2022 Raf Kinase Inhibitory Protein (RKIP) maintains cellular robustness and prevents the progression of diseases such as cancer and heart disease by regulating key kinase cascades including MAP kinase and protein kinase A (PKA). Phosphorylation of RKIP at S153 by Protein Kinase C (PKC) triggers a switch from inhibition of Raf to inhibition of the G protein ...
Lee J +9 more
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Raf kinase inhibitory protein (RKIP): functional pleiotropy in the mammalian brain. [PDF]
Crit Rev Oncog, 2014 In 1984, a cytosolic protein was isolated from bovine brain and coined phosphatidylethanolamine binding protein (PEBP) to describe its phospholipid-binding potential. Its cellular function remained elusive for more than a decade until it was discovered that PEBP had the ability to suppress the Raf1-mitogen activated protein kinase (MAPK) pathway ...
Ling HH +3 more
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Clinical and prognostic significance of Raf kinase inhibitory protein expression in gastrointestinal stromal tumors. [PDF]
World J Gastroenterol, 2018 To detect the expression of Raf kinase inhibitory protein (RKIP) in gastrointestinal stromal tumors (GISTs) and to analyze its relationship with clinicopatholgical characteristics and prognosis of this disease.Sixty-three patients with pathologically diagnosed GISTs who underwent surgical resection at the Shengjing Hospital of China Medical University ...
Wang Y, Chen JJ, Wang XF, Wang Q.
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Raf Kinase Inhibitory Protein Regulates Raf-1 but Not B-Raf Kinase Activation [PDF]
Journal of Biological Chemistry, 2005 Raf kinase inhibitory protein (RKIP; also known as phosphatidylethanolamine-binding protein or PEBP) is a modulator of the Raf/MAPK signaling cascade and a suppressor of metastatic cancer. Here, we show that RKIP inhibits MAPK by regulating Raf-1 activation; specifically, RKIP acts subsequent to Raf-1 membrane recruitment, prevents association of Raf-1
Nicholas, Trakul +4 more
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