Results 191 to 200 of about 60,399 (263)

Targeting the MAPK Pathway in Brain Tumors: Mechanisms and Therapeutic Opportunities. [PDF]

Cancers (Basel)
Vrachas D, Kosma E, Giannopoulou AI, Margoni A, Gargalionis AN, El-Habr EA, Piperi C, Adamopoulos C.   +7 more
europepmc   +1 more source

PTRF Confers Melanoma‐Acquired Drug Resistance Through the Upregulation of EGFR

Cell Proliferation, Volume 59, Issue 2, February 2026.
The upregulation of PTRF, a critical caveolar component, and the concomitant increase in caveolae number potentiate cellular proliferation and survival pathways, thereby contributing to melanoma drug resistance. ABSTRACT Melanoma is the most serious type of skin cancer. About half of all melanomas have activating BRAF mutations.
Miao Wang, Ying Cao, Chengcheng Ren, Ke Wang, Yaxiang Wang, Xiaoying Wu, Jian Mao, Qian Liang, Qian Zhang, Hezhe Lu, Xiaowei Xu, Yu‐Sheng Cong   +11 more
wiley   +1 more source

Targeting Kinase Suppressor of Ras 1 (KSR1) for Cancer Therapy. [PDF]

Pharmaceutics
Moon H, Park H, Lee S, Lee S, Ro SW.
europepmc   +1 more source

The importin‐alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus

The FEBS Journal, Volume 293, Issue 3, Page 894-917, February 2026.
The plant hormone ethylene regulates plant growth, ripening, senescence, and stress responses. The hormonal signal transmission, from receptors at the ER membrane to the transcriptional regulators in the nucleus, is still not completely understood.
Fabian Wynen, Jan Eric Maika, Raphael Josef Eberle, Nina Jahnke, Marcel Wiermer, Laura Hartmann, Rüdiger Simon, Georg Groth   +7 more
wiley   +1 more source

Advancing Hepatocellular Carcinoma Therapy with Next-Generation Molecular and Immunotherapeutics. [PDF]

J Hepatocell Carcinoma
Hassan M, Hussain I, Ahmad K, Zafar S, Khalid A, Haseeb M, Hussain N, Ghafar MA.   +7 more
europepmc   +1 more source

Rice blast pathogen effector AvrPib compromises disease resistance by targeting Raf‐like protein kinase OsMAPKKK72 to inhibit MAPK signaling

Journal of Integrative Plant Biology, Volume 68, Issue 2, Page 486-501, February 2026.
The rice Raf‐like protein kinase OsMAPKKK72 acts as a scaffold to modulate MAPK signaling. To invade rice plants, the blast fungus delivers the effector AvrPib to target OsMAPKKK72, suppressing MAPK activation and rice blast resistance. ABSTRACT Phytopathogens, such as the rice blast fungus Magnaporthe oryzae, suppress plant immunity for reproduction ...
Zhanchun Wang, Guitao Zhong, Beibei Zhang, Yilin Xie, Yufan Gan, Dingzhong Tang, Wei Wang   +6 more
wiley   +1 more source

Future heatwave conditions inhibit CO2‐induced stomatal closure in wheat

New Phytologist, Volume 249, Issue 3, Page 1234-1252, February 2026.
Summary As global temperatures and the severity of droughts continue to increase, food crops will more frequently experience high vapour pressure deficit (VPD) during heatwave events. However, the interactive effects of rising atmospheric CO2 and high‐VPD heatwaves on crop water fluxes and yields are currently unknown.
Robert S. Caine, Muhammad S. Khan, Yixiang Shan, Colin P. Osborne, Holly L. Croft   +4 more
wiley   +1 more source

Characterization and inhibitor sensitivity of ARAF, BRAF, and CRAF kinases. [PDF]

J Biol Chem
Tkacik E, Jang DM, Boxer K, Ha BH, Eck MJ.   +4 more
europepmc   +1 more source

Biochemical and Physiological Effects of Galanin in Health and Disease

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Galanin is a biologically active neuropeptide hormone that mediates its effects through three galanin receptors. Galanin signaling induces changes in glucose homeostasis amongst others and plays a dynamic role in the physiological health of many organ systems.
Patrick Mireles, Yubo Wang, Kathryn Rhodes, Sharon DeMorrow   +3 more
wiley   +1 more source