Current Therapeutic Research, 2020 : Background: The increasing rate of cancer chemoresistance and adverse side effects of therapy have led to the wide use of various chemotherapeutic combinations in cancer management, including lymphoid malignancy. Objective: We investigated the effects
Isnatin Miladiyah, Dr +5 more
doaj +1 more source
PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex [PDF]
, 2017 The levels of cAMP are regulated by phosphodiesterase enzymes (PDEs), which are targets for the treatment of inflammatory disorders. We have previously shown that PDE8 regulates T cell motility.
Baillie, George S. +7 more
core +1 more source
Inhibition of pMAPK14 Overcomes Resistance to Sorafenib in Hepatoma Cells with Hepatitis B Virus
Translational Oncology, 2018 Hepatitis B virus (HBV) targets the liver and is a major driver for liver cancer. Clinical data suggest that HBV infection is associated with reduced response to treatment with the multi-kinase inhibitor sorafenib, the first available molecularly ...
Dvora Witt-Kehati +4 more
doaj +1 more source
Autophagic cell death associated to Sorafenib in renal cell carcinoma is mediated through Akt inhibition in an ERK1/2 independent fashion. [PDF]
PLoS ONE, 2018 OBJECTIVES:To fully clarify the role of Mitogen Activated Protein Kinase in the therapeutic response to Sorafenib in Renal Cell Carcinoma as well as the cell death mechanism associated to this kinase inhibitor, we have evaluated the implication of ...
Leticia Serrano-Oviedo +12 more
doaj +1 more source
Synergistic antitumour activity of RAF265 and ZSTK474 on human TT medullary thyroid cancer cells [PDF]
, 2015 Medullary thyroid cancer (MTC) is an aggressive malignancy responsible for up to 14% of all thyroid cancer-related deaths. It is characterized by point mutations in the rearranged during transfection (RET) proto-oncogene.
Barollo, Susi +11 more
core +1 more source
Raf kinase inhibitory protein knockout mice: Expression in the brain and olfaction deficit [PDF]
Brain Research Bulletin, 2007 Raf kinase inhibitory protein (RKIP-1) is involved in the regulation of the MAP kinase, NF-kappaB, and GPCR signaling pathways. It is expressed in numerous tissues and cell types and orthologues have been documented throughout the animal and plant kingdoms.
Steven, Theroux +6 more
openaire +2 more sources
Mechanism of regulation of Raf-1 by Ca2+/Calmodulin-dependent kinase II [PDF]
, 2011 The calcium-calmodulin dependent kinase II (CaMKII) is an ubiquitous serine/threonine protein kinase involved in multiple signalings and biological functions.
Salzano, Marcella
core +1 more source
Promoter methylation of Raf kinase inhibitory protein: A significant prognostic indicator for patients with gastric adenocarcinoma. [PDF]
Exp Ther Med, 2014 DNA methylation has an important role in the development of carcinomas. As a metastasis suppressor gene, Raf kinase inhibitory protein (RKIP) suppresses tumor cell invasion and metastasis. In the present study, the associations between RKIP protein expression and promoter methylation with clinicopathological parameters, prognosis and survival rates in ...
Li DX, Cai HY, Wang X, Feng YL, Cai SW.
europepmc +4 more sources
Reciprocal regulation of PKA and rac signaling [PDF]
, 2013 Activated G protein-coupled receptors (GPCRs) and receptor tyrosine kinases relay extracellular signals through spatial and temporal controlled kinase and GTPase entities.
A. Riml +47 more
core +1 more source
Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let‐7 [PDF]
The EMBO Journal, 2009 Raf kinase inhibitory protein (RKIP) negatively regulates the MAP kinase (MAPK), G protein-coupled receptor kinase-2, and NF-κB signalling cascades. RKIP has been implicated as a metastasis suppressor for prostate cancer, but the mechanism is not known.
Dangi-Garimella, Surabhi +7 more
openaire +2 more sources