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The anatomy of rage: conceptualization, operationalization, and validation of a new measurement scale [PDF]

open access: yesFrontiers in Psychiatry
IntroductionDespite its prevalence among gamers, rage remains an understudied phenomenon in digital gaming. The present study aimed to conceptualize rage as an emotional response to in-game failure or frustration and to develop a reliable and valid self ...
Natalia Michałkiewicz   +2 more
doaj   +2 more sources

Impact of HMGB1, RAGE, and TLR4 in Alzheimer’s Disease (AD): From Risk Factors to Therapeutic Targeting

open access: yesCells, 2020
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder and a leading cause of dementia, with accumulation of amyloid-beta (Aβ) and neurofibrillary tangles (NFTs) as defining pathological features.
Yam Nath Paudel   +2 more
exaly   +3 more sources

阿司匹林和氯吡格雷联合应用 对小鼠脑缺血恢复期RAGE及 sRAGE表达的影响 Effects of Aspirin Combined with Clopidogrel on the Expression of RAGE and sRAGE during the Convalescence of Cerebral Ischemia in Mice

open access: yesZhongguo cuzhong zazhi, 2022
目的 探索阿司匹林和氯吡格雷联合应用对小鼠大脑中动脉远端缺血再灌注模型恢复期晚期糖基化终末产物受体(receptor for advanced glycation end products,RAGE)及可溶性晚期糖基化终末产物受体(soluble receptor for advanced glycation end products,sRAGE)表达的影响及其机制。 方法 60只C57BL/6J雄性小鼠随机分为假手术组、溶剂组、阿司匹林和氯吡格雷联合组(双抗组),每组20只 ...
温少红, 刘向荣, 顺英, 董雯, 陈青芳, 陈文涛, 李子孝, 王春娟
doaj   +1 more source

Electroacupuncture inhibits the expression of HMGB1/RAGE and alleviates injury to the primary motor cortex in rats with cerebral ischemia

open access: yesTranslational Neuroscience, 2023
The high-mobility group box 1 (HMGB1)/receptor for advanced glycation end products (RAGE) signaling pathway holds promise as a potential therapeutic target for ischemic brain injury. The effects of FPS-ZM1 and electroacupuncture (EA) on activation of the
Nie Zeyin   +3 more
doaj   +1 more source

For a Research Agenda on Negative Politics

open access: yesPolitics and Governance, 2022
This thematic issue deals with the “negative” side of politics, more specifically with dynamics of political aggressiveness and ideological opposition in voters and elites. Why do candidates “go negative” on their rivals?
Alessandro Nai   +4 more
doaj   +1 more source

MLKL Regulates Rapid Cell Death-independent HMGB1 Release in RSV Infected Airway Epithelial Cells

open access: yesFrontiers in Cell and Developmental Biology, 2022
Respiratory syncytial virus (RSV)-induced bronchiolitis is a significant contributor to infant morbidity and mortality. Previously, we identified that necroptosis, a pro-inflammatory form of cell death mediated by receptor-interacting serine/threonine ...
Jennifer Simpson   +5 more
doaj   +1 more source

Redox Signaling and Advanced Glycation Endproducts (AGEs) in Diet-Related Diseases

open access: yesAntioxidants, 2020
Diets are currently characterized by elevated sugar intake, mainly due to the increased consumption of processed sweetened foods and drinks during the last 40 years. Diet is the main source of advanced glycation endproducts (AGEs).
Vanesa Cepas   +3 more
doaj   +1 more source

Biomarker Potential of the Soluble Receptor for Advanced Glycation End Products to Predict Bronchopulmonary Dysplasia in Premature Newborns

open access: yesFrontiers in Pediatrics, 2021
Bronchopulmonary dysplasia (BPD) is a common cause of pulmonary disease in preterm infants. The soluble receptor for advanced glycation end products (sRAGE) is implicated in the development of various pulmonary diseases.
Hayato Go   +12 more
doaj   +1 more source

Anger: what we know and what we don't want to know. Scientific contributions and social representation.

open access: yesMediterranean Journal of Clinical Psychology, 2020
Introduction: Aggressiveness is an essential component of every living thing and the experience of anger is common to all historical periods, all ages and all mental structures. Different forms and narrative ways of anger can be found in each society and
Paola Manfredi
doaj   +1 more source

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