Results 11 to 20 of about 48,769 (198)

Members of the ran family of stress-inducible small GTP-binding proteins are differentially regulated in sweetpotato plants

Journal of Plant Biotechnology, 2013
Abstract Ran is a small GTP-binding protein that binds and subsequently hydrolyzes GTP. The functions of Ran in nuclear transport and mitotic progression are well conserved in plants and animals. In animal cells, stress treatments cause Ran relocalization and slowing of nuclear transport, but the role of Ran proteins in plant cells exposed to stress is
Young-Hwa Kim, Gyung Hye Huh
openalex   +4 more sources

Inter-cellular transport of ran GTPase. [PDF]

PLoS ONE, 2015
Ran, a member of the Ras-GTPase superfamily, has a well-established role in regulating the transport of macromolecules across the nuclear envelope (NE). Ran has also been implicated in mitosis, cell cycle progression, and NE formation. Over-expression of
Deepak Khuperkar, Mary Helen, Indrasen Magre, Jomon Joseph   +3 more
doaj   +1 more source

Overexpression of a Small GTP-Binding Protein Ran1 in Arabidopsis Leads to Promoted Elongation Growth and Enhanced Disease Resistance against P. syringae DC3000.

The Plant Journal, 2021
Plants resist infection through an innate immune response, which is usually associated with slowing of growth. The molecular mechanisms underlying the trade-off between plant growth and defense remain unclear.
Peipei Xu, Wei Ma, Jing Liu, Hu Jinbo, Weiming Cai   +4 more
semanticscholar   +1 more source

The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes. [PDF]

PLoS ONE, 2015
The inner nuclear membrane (INM) protein Nemp1/TMEM194A has previously been suggested to be involved in eye development in Xenopus, and contains two evolutionarily conserved sequences in the transmembrane domains (TMs) and the C-terminal region, named ...
Takashi Shibano, Hiroshi Mamada, Fumihiko Hakuno, Shin-Ichiro Takahashi, Masanori Taira   +4 more
doaj   +1 more source

Structural characterisation of the nuclear import receptor importin alpha in complex with the bipartite NLS of Prp20. [PDF]

PLoS ONE, 2013
The translocation of macromolecules into the nucleus is a fundamental eukaryotic process, regulating gene expression, cell division and differentiation, but which is impaired in a range of significant diseases including cancer and viral infection.
Noelia Roman, Mary Christie, Crystall M D Swarbrick, Bostjan Kobe, Jade K Forwood   +4 more
doaj   +1 more source

RANBP10 promotes glioblastoma progression by regulating the FBXW7/c-Myc pathway

Cell Death and Disease, 2021
RAN binding protein 10 (RANBP10), a ubiquitously expressed and evolutionarily conserved protein, as a RAN-GTP exchange factor (GEF) to regulate several factors involved in cellular progression.
Jianbing Hou, Yudong Liu, Pan Huang, Yutao Wang, Dakun Pei, Ruoyue Tan, Yundong Zhang, Hongjuan Cui   +7 more
doaj   +1 more source

GEF-independent Ran activation shifts a fraction of the protein to the cytoplasm and promotes cell proliferation

Molecular Biomedicine, 2020
Ran (Ras-related nuclear protein) plays several important roles in nucleo-cytoplasmic transport, mitotic spindle formation, nuclear envelope/nuclear pore complex assembly, and other functions in the cytoplasm, as well as in cellular transformation when ...
Jinhan Zhou, Yuping Tan, Yuqing Zhang, Aiping Tong, Xiaofei Shen, Xiaodong Sun, Da Jia, Qingxiang Sun   +7 more
doaj   +1 more source

Alteration in endometrial proteins during early- and mid-secretory phases of the cycle in women with unexplained infertility. [PDF]

PLoS ONE, 2014
BACKGROUND: Compromised receptivity of the endometrium is a major cause of unexplained infertility, implantation failure and subclinical pregnancy loss.
Murli Manohar, Huma Khan, Vijay Kumar Sirohi, Vinita Das, Anjoo Agarwal, Amita Pandey, Waseem Ahmad Siddiqui, Anila Dwivedi   +7 more
doaj   +1 more source

Molecular Characterization and Functional Analysis of Annulate Lamellae Pore Complexes in Nuclear Transport in Mammalian Cells. [PDF]

PLoS ONE, 2015
Annulate lamellae are cytoplasmic organelles containing stacked sheets of membranes embedded with pore complexes. These cytoplasmic pore complexes at annulate lamellae are morphologically similar to nuclear pore complexes at the nuclear envelope ...
Sarita Raghunayakula, Divya Subramonian, Mary Dasso, Rita Kumar, Xiang-Dong Zhang   +4 more
doaj   +1 more source

Secretome profiling of Artemisia absinthium extract-loaded polymeric nanoparticle-treated MCF-7 and MDA-MB-231 revealed perturbation in microtubule assembly and cell migration

Frontiers in Oncology, 2023
IntroductionArtemisia absinthium (wormwood) exhibits anticancer properties by inhibiting proliferation and causing cell death in breast cancer. Targeted drug delivery of A. absinthium nanoformulation using N-isopropyl acrylamide, N-vinyl pyrrolidone, and
Sana Kauser, Mohd Mughees, Irengbam Rocky Mangangcha, Sanskriti Swami, Saima Wajid   +4 more
doaj   +1 more source