Results 21 to 30 of about 10,982 (172)

Comparative Proteomic Analysis of Anti-Cancer Mechanism by Periplocin Treatment in Lung Cancer Cells

Cellular Physiology and Biochemistry, 2014
Background: Periplocin is used for treatment of rheumatoid arthritis, reinforcement of bones and tendons, palpitations or shortness of breath and lower extremity edema in traditional medicine. Our previous findings suggested that periplocin could inhibit
Zejun Lu, Qi Song, Jinliang Yang, Xiangfei Zhao, Xinhong Zhang, Ping Yang, Jingbo Kang   +6 more
doaj   +1 more source

The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyond

Frontiers in Cell and Developmental Biology, 2016
The small GTPase Ran regulates the interaction of transport receptors with a number of cellular cargo proteins. The high affinity binding of the GTP-bound form of Ran to import receptors promotes cargo release, whereas its binding to export receptors ...
Tommaso eCavazza, Tommaso eCavazza, Isabelle eVernos, Isabelle eVernos, Isabelle eVernos   +4 more
doaj   +1 more source

Topological and functional properties of the small GTPases protein interaction network. [PDF]

PLoS ONE, 2012
Small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) regulate key cellular processes such as signal transduction, cell proliferation, cell motility, and vesicle transport.
Anna Delprato
doaj   +1 more source

The importin beta superfamily member RanBP17 exhibits a role in cell proliferation and is associated with improved survival of patients with HPV+ HNSCC

BMC Cancer, 2022
Background More than twenty years after its discovery, the role of the importin beta superfamily member Ran GTP-binding protein (RanBP) 17 is still ill defined.
Robert Mandic, André Marquardt, Philip Terhorst, Uzma Ali, Annette Nowak-Rossmann, Chengzhong Cai, Fiona R. Rodepeter, Thorsten Stiewe, Bernadette Wezorke, Michael Wanzel, Andreas Neff, Boris A. Stuck, Michael Bette   +12 more
doaj   +1 more source

Identification of alternatively spliced MsRan transcripts involved in low temperature response in Musa spp.

Biologia Plantarum, 2017
Ran is involved in response to external stimuli. In this study, six MsRan gene cDNA sequences were isolated from wild banana (Musa spp. AB group) from Sanming City, China.
Y. L. Zhang, Z. Z. Fang, Z. X. Lai
doaj   +1 more source

The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells

BMC Cell Biology, 2010
Background Regulator of chromosome condensation 1 (RCC1) is the guanine nucleotide exchange factor for Ran GTPase. Localised generation of Ran-GTP by RCC1 on chromatin is critical for nucleocytoplasmic transport, mitotic spindle assembly and nuclear ...
Sanderson Helen S, Hood Fiona E, Hitakomate Ekarat, Clarke Paul R   +3 more
doaj   +1 more source

In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity

Translational Oncology, 2019
Ovarian cancer is the second most common gynecological malignancy worldwide. Paclitaxel is particularly important in the therapy of ovarian carcinomas, but the treatment efficacy is counteracted by the development of resistance to chemotherapy.
Lucia D'Antona, Vincenzo Dattilo, Giada Catalogna, Domenica Scumaci, Claudia Vincenza Fiumara, Francesca Musumeci, Giuseppe Perrotti, Silvia Schenone, Rossana Tallerico, Cristina B. Spoleti, Nicola Costa, Rodolfo Iuliano, Giovanni Cuda, Rosario Amato, Nicola Perrotti   +14 more
doaj   +1 more source

Unique and differential protein signatures within the mononuclear cells of HIV-1 and HCV mono-infected and co-infected patients

Clinical Proteomics, 2012
Background Pathogenesis of liver damage in patients with HIV and HCV co-infection is complex and multifactorial. Although global awareness regarding HIV-1/HCV co-infection is increasing little is known about the pathophysiology that mediates the rapid ...
Boukli Nawal M, Shetty Vivekananda, Cubano Luis, Ricaurte Martha, Coelho-dos-Reis Jordana, Nickens Zacharie, Shah Punit, Talal Andrew H, Philip Ramila, Jain Pooja   +9 more
doaj   +1 more source

Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity

Cells, 2019
DEAD-box helicase 3, X-linked (DDX3X) regulates the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated antiviral response, but can also be a host factor contributing to the replication of viruses of significance to human health, such as ...
Steven M. Heaton, Sarah C. Atkinson, Melissa N. Sweeney, Sundy N. Y. Yang, David A. Jans, Natalie A. Borg   +5 more
doaj   +1 more source

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, EarlyView.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source