Results 71 to 80 of about 48,769 (198)

RAP2B: a RAS-related GTP-binding protein from platelets.

Proceedings of the National Academy of Sciences of the United States of America, 1990
A platelet cDNA expression library was screened with the monoclonal antibody M90, which recognizes a specific epitope on RAS-encoded p21 proteins (amino acids 107-130).
C. Ohmstede, F. Farrell, B. Reep, K. Clemetson, E. Lapetina   +4 more
semanticscholar   +1 more source

OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination [PDF]

, 2016
Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that reversible ubiquitination of RAS GTPases dramatically affects their activity, suggesting that ...
Asbagh, Layka Abbasi, Aushev, Vasily N, Baietti, Maria Francesca, Crowther, Jonathan, Lievens, Sam, Martínez García, David, Radaelli, Enrico, Sablina, Anna A, Simicek, Michal, Steklov, Mikhail, Tavernier, Jan   +10 more
core   +1 more source

Small‐Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation

ChemMedChem, EarlyView.
Small molecules form a covalent bond at KRAS tyrosine and inhibit its activation by guanine exchange factors in biochemical assays and mammalian cells. The development of the KRAS G12C inhibitor sotorasib is a major advance toward drugging KRAS. However, the G12C mutation is only found in about 10% of KRAS‐driven tumors. KRAS possesses several tyrosine
Alexander D. Landgraf, Robert Brenner, Mona K. Ghozayel, Khuchtumur Bum‐Erdene, Giovanni Gonzalez‐Gutierrez, Samy O. Meroueh   +5 more
wiley   +1 more source

Kinesin‐Driven De‐Mixing of Cytoskeleton Composites Drives Emergent Mechanical Properties

Macromolecular Rapid Communications, EarlyView.
Optical tweezers microrheology and fluorescence microscopy is coupled with simulations and mathematical modeling to discover that active cytoskeleton composites exhibit a rich ensemble of emergent mechanical response characteristics, from yielding to stiffening, governed by kinesin‐driven restructuring from well‐mixed interpenetrating double‐networks ...
Janet Sheung, Christopher Gunter, Katarina Matic, Mehrzad Sasanpour, Jennifer L. Ross, Parag Katira, Megan T. Valentine, Rae M. Robertson‐Anderson   +7 more
wiley   +1 more source

Simulation of spontaneous G protein activation reveals a new intermediate driving GDP unbinding [PDF]

, 2018
Activation of heterotrimeric G proteins is a key step in many signaling cascades. However, a complete mechanism for this process, which requires allosteric communication between binding sites that are ~30 Å apart, remains elusive.
Blumer, Kendall J, Bowman, Gregory R, Singh, Sukrit, Sun, Xianqiang   +3 more
core   +1 more source

The membrane bound N-terminal domain of human adenosine diphosphate ribosylation factor-1 (ARF1) [PDF]

, 2003
The small G protein adenosine diphosphate ribosylation factor-1 (ARF1) is activated by cell membrane binding of a self-folding N-terminal domain. We present a model of the human ARF1 N-terminal peptide in planar lipid bilayers, determined from neutron ...
Amor, Antonny, Bé, Bohm, Bradshaw, Bradshaw, Bradshaw, Brasseur, Darkes, Duff, Franco, Goldberg, Gordeliy, Jacobs, Johnson, Kraulis, Mé, Mayer, Merritt, Roth, Sreerama, Wiener, Wiener   +22 more
core   +1 more source

The Actin‐Binding Prolyl‐Isomerase Par17 Sustains Its Substrate Selectivity by Interdomain Allostery

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The human peptidyl‐prolyl‐cis/trans isomerases (PPIases), Parvulin 14 and Parvulin 17, accelerate the cis/trans isomerization of Xaa‐Pro moieties within protein sequences. By modulating the respective binding interfaces of their target proteins, they play a crucial role in determining the fate of their substrates within the cell. Although both
Anna Sternberg, Jennifer Lynne Borger, Mathilda Thies, Anja Matena, Mike Blueggel, Bianca E. Kamba, Christine Beuck, Farnusch Kaschani, Markus Kaiser, Peter Bayer   +9 more
wiley   +1 more source

Gz, a guanine nucleotide-binding protein with unique biochemical properties [PDF]

, 1990
Cloning of a complementary DNA (cDNA) for Gz alpha, a newly appreciated member of the family of guanine nucleotide-binding regulatory proteins (G proteins), has allowed preparation of specific antisera to identify the protein in tissues and to assay it ...
Casey, Patrick J., Fong, Henry K. W., Gilman, Alfred G., Simon, Melvin I.   +3 more
core  

The Ras protein superfamily: Evolutionary tree and role of conserved amino acids [PDF]

, 2012
The Ras superfamily is a fascinating example of functional diversification in the context of a preserved structural framework and a prototypic GTP binding site.
Fuentes, Gloria, Rausell, Antonio, Rojas, A. M., Valencia, Alfonso   +3 more
core   +1 more source

Nonequilibrium Self‐Assembly of Microtubules Through Stepwise Sequential Interactions of DNA

Small, EarlyView.
This study presents a molecular swarm system activated through stepwise DNA interactions. DNA‐tethered microtubules exchange signals via specific sequence recognition, enabling sequential assembly and communication. This innovative approach advances autonomous molecular machine development, offering potential for adaptive, active, and complex ...
Jakia Jannat Keya, Mousumi Akter, Yuta Yamasaki, Yoshiyuki Kageyama, Kazuki Sada, Akinori Kuzuya, Akira Kakugo   +6 more
wiley   +1 more source