Results 71 to 80 of about 10,982 (172)

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, Volume 16, Issue 1, Page 199-221, January 2026.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. del Mercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
wiley   +1 more source

Development and Characterization of a Noncovalent Stimulator of Interferon Genes Proteolysis‐Targeting Chimeras

ChemMedChem, Volume 21, Issue 1, January 2026.
The design, synthesis, and initial biological evaluation of noncovalent stimulator of interferon genes degraders are presented. The lead from this series, BH690L, exhibits an effective concentration for half‐maximal degradation (DC50) of 11.3 nM and a maximum level of degradation (Dmax) of 0.67.
Bo Hu, Adam S. Duerfeldt
wiley   +1 more source

SNRK3.15 Is a Crucial Component of the Sulfur Deprivation Response in Arabidopsis thaliana

Plant Direct, Volume 10, Issue 1, January 2026.
ABSTRACT Sulfate deprivation (–S) results in numerous metabolic and phenotypic alterations in plants. Kinases are often key players in transducing nutrient status signals to molecular components involved in metabolic and developmental program regulation, but despite the physiological importance of sulfur, to date, no signaling kinases have been ...
Anastasia Apodiakou, Elmien Heyneke, Saleh Alseekh, Pinnapat Pinsorn, Sabine Metzger, Stanislav Kopriva, Waltraud Schulze, Rainer Hoefgen, Sarah J. Whitcomb   +8 more
wiley   +1 more source

Purification and characterization of recombinant human translation initiation factor eIF3

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Eukaryotic translation initiation factor 3 (eIF3) is an essential factor in protein synthesis. In mammals, it is a ~800 kDa complex composed of 12–13 subunits. Biochemical and mechanistic studies of the function of eIF3 and its individual subunits in translation require purified eIF3.
Irene Diaz‐Lopez, Yuliya Gordiyenko, Philipp K. Zuber, Xueyan Li, V. Ramakrishnan   +4 more
wiley   +1 more source

Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta.

, 1996
Junona Moroianu, Günter Blobel, A Radu
openalex   +2 more sources

Expression of the Xenopus GTP-binding protein gene Ran during embryogenesis

Expression of the Xenopus GTP-binding protein gene Ran during embryogenesis
The Ran gene family encodes small GTP binding proteins that are associated with a variety of nuclear processes. We isolated a Xenopus Ran cDNA and analyzed the pattern of expression of this gene during embryogenesis. Ran is expressed maternally and later in the CNS, neural crest, mesenchyme, eyes, and otic vesicles.
openaire  

Phosphorylation induces altered protonation states and allosterically regulates Rac1–RhoGDI complex

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Rho GTPases, critical for cellular functions like motility, are sequestered in an inactive GDP‐bound state by RhoGDI. While site‐specific RhoGDI phosphorylation is known to trigger selective GTPase release, the precise mechanisms remain elusive.
Krishnendu Sinha, Amit Kumawat, Hyunbum Jang, Ruth Nussinov, Suman Chakrabarty   +4 more
wiley   +1 more source

Extensile Active Hydrogels Driven by Living FtsZ Polymers

Small, Volume 22, Issue 3, 13 January 2026.
Upon post‐gelation activation with Mg2⁺/GTP, living FtsZ polymers treadmill inside a polyacrylamide network, generating extensile internal stresses that drive isotropic swelling and softening. Interpreting mechanics against a Flory–Rehner swelling baseline separates passive dilution from genuine activity, revealing an FR‐normalized permittivity that ...
Mikheil Kharbedia, Diego Herráez‐Aguilar, Macarena Calero, Horacio López‐Menendez, Clara Luque‐Rioja, Lara H. Moleiro, Cruz Santos, Pilar Lillo, Francisco Monroy   +8 more
wiley   +1 more source

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi, Shuang Liu, Yasuyuki Suzuki, Yuuka Shibata, Shizuo Yamada   +4 more
wiley   +1 more source