Randomised controlled trials [PDF]
Archives of Disease in Childhood, 1997 Editor,—We read with interest the recent editorial on evidence-based child health.1 We were struck by how easy it is to overlook a randomised controlled trial (RCT) in the Archives (or any other journal) if this is not indicated in the title or abstract. We wondered if this was the …
Robert A. Phillips, Tamar Rothenberg
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On the use of non-concurrent controls in platform trials: A scoping review [PDF]
Trials 2023, 2022 Platform trials gained popularity during the last few years as they increase flexibility compared to multi-arm trials by allowing new experimental arms entering when the trial already started. Using a shared control group in platform trials increases the trial efficiency compared to separate trials.
arxiv +1 more source
Randomised controlled trial of mesalazine in IBS [PDF]
Gut, 2014 Low-grade intestinal inflammation plays a role in the pathophysiology of IBS. In this trial, we aimed at evaluating the efficacy and safety of mesalazine in patients with IBS.We conducted a phase 3, multicentre, tertiary setting, randomised, double-blind, placebo-controlled trial in patients with Rome III confirmed IBS.
BARBARA, GIOVANNI +21 more
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On model-based time trend adjustments in platform trials with non-concurrent controls [PDF]
BMC Medical Research Methodology (2022), 2021 Platform trials can evaluate the efficacy of several treatments compared to a control. The number of treatments is not fixed, as arms may be added or removed as the trial progresses. Platform trials are more efficient than independent parallel-group trials because of using shared control groups.
arxiv +1 more source
The group-based social skills training SOSTA-FRA in children and adolescents with high functioning autism spectrum disorder - study protocol of the randomised, multi-centre controlled SOSTA - net trial [PDF]
, 2013 Background: Group-based social skills training (SST) has repeatedly been recommended as treatment of choice in high-functioning autism spectrum disorder (HFASD). To date, no sufficiently powered randomised controlled trial has been performed to establish
Bender, Stephan +6 more
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Exploring demographic and lifestyle associations with patient experience following telephone triage by a primary care doctor or nurse:secondary analyses from a cluster randomised controlled trial [PDF]
, 2015 The ESTEEM trial was a cluster randomised controlled trial that compared two telephone triage management systems (general practitioner (GP) or a nurse supported by computer decision support software) with usual care, in response to a request for same-day
Bunn +18 more
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Manual-assisted cognitive therapy for self-harm in personality disorder and substance misuse: a feasibility trial [PDF]
, 2014 <b>Aims and method</b> To assess the feasibility of conducting a larger, definitive randomised controlled trial of manual-assisted cognitive therapy (MACT), a brief focused therapy to address self-harm and promote engagement in services.
Brown, Tom M. +4 more
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Facilitating return to work through early specialist health-based interventions (FRESH): protocol for a feasibility randomised controlled trial [PDF]
, 2015 Background Over one million people sustain traumatic brain injury each year in the UK and more than 10 % of these are moderate or severe injuries, resulting in cognitive and psychological problems that affect the ability to work.
A Franulic +26 more
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An intervention for people with learning disabilities and epilepsy [PDF]
, 2015 Date of Acceptance: 09/01/2015Epilepsy is relatively common in people with learning disabilities, and can be complex and refractory to treatment, with negative effects on quality of life and service costs.
Durand, Marie-Anne +2 more
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Thinking territory historically. [PDF]
, 2010 BACKGROUND: While the randomised controlled trial (RCT) is generally regarded as the design of choice for assessing the effects of health care, within the social sciences there is considerable debate about the relative suitability of RCTs and non ...
Bagnall, A +10 more
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