Results 1 to 10 of about 760,498 (359)

Physio4FMD: protocol for a multicentre randomised controlled trial of specialist physiotherapy for functional motor disorder [PDF]

BMC Neurology, 2019
Background Patients with functional motor disorder (FMD) experience persistent and disabling neurological symptoms such as weakness, tremor, dystonia and disordered gait.
Glenn Nielsen, Jon Stone, Marta Buszewicz, Alan Carson, Laura H. Goldstein, Kate Holt, Rachael Hunter, Jonathan Marsden, Louise Marston, Hayley Noble, Markus Reuber, Mark J. Edwards, on behalf of the Physio4FMD Collaborative Group   +12 more
doaj   +8 more sources

Spirometry to manage asthma in children: study protocol for a randomised controlled trial (SPIROMAC) [PDF]

Trials
Background Asthma affects over 1 million children across the UK, and preventative treatment is guided subjectively by patient symptoms. Spirometry is an objective test of lung function and can be used in children to guide treatment.
Victoria Bell, Nicole Sergenson, Seonaidh Cotton, Chukwuemeka David Emele, Ruth Thomas, Lorna Aucott, Mark Forrest, Erol A. Gaillard, Erika J. Kennington, Graeme MacLennan, Ian Sinha, Thenmalar Vadiveloo, Neil W. Scott, Steve Turner   +13 more
doaj   +2 more sources

Randomised controlled trials [PDF]

Archives of Disease in Childhood, 1997
Editor,—We read with interest the recent editorial on evidence-based child health.1 We were struck by how easy it is to overlook a randomised controlled trial (RCT) in the Archives (or any other journal) if this is not indicated in the title or abstract. We wondered if this was the …
R, Phillips, T, Rothenberg
openaire   +3 more sources

The APPLE Tree programme: Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build REsiliEnce—randomised controlled trial

Trials, 2022
Background Large-scale trials of multidomain interventions show that modifying lifestyle and psychological risk factors can slow cognitive decline. We aim to determine if a lower intensity, personally tailored secondary dementia prevention programme for ...
M. Poppe, L. Duffy, N. L. Marchant, J. A. Barber, R. Hunter, N. Bass, A. M. Minihane, K. Walters, P. Higgs, P. Rapaport, I. A. Lang, S. Morgan-Trimmer, J. Huntley, Z. Walker, H. Brodaty, H. C. Kales, K. Ritchie, A. Burton, J. Wenborn, A. Betz, C. Cooper   +20 more
doaj   +1 more source

Adapting the randomised controlled trial (RCT) for precision medicine: introducing the nested-precision RCT (npRCT)

Trials, 2021
Adaptations to the gold standard randomised controlled trial (RCT) have been introduced to decrease trial costs and avoid high sample sizes. To facilitate development of precision medicine algorithms that aim to optimise treatment allocation for ...
Nils Kappelmann, Bertram Müller-Myhsok, Johannes Kopf-Beck   +2 more
doaj   +1 more source

Does prospective acceptability of an intervention influence refusal to participate in a randomised controlled trial? An interview study

Contemporary Clinical Trials Communications, 2021
Background: The generalizability of findings of Randomised Controlled Trials (RCTs) is undermined by low or biased recruitment. Reasons for participant refusal are infrequently reported in published literature. Aims: To apply the Theoretical Framework of
Mandeep Sekhon, Martin Cartwright, Sadie Lawes-Wickwar, Hayley McBain, Daniel Ezra, Stanton Newman, Jill J Francis   +6 more
doaj   +1 more source

Optimising recruitment to the HAND-1 RCT feasibility study: integration of the QuinteT Recruitment Intervention (QRI)

Pilot and Feasibility Studies, 2020
Background Recruitment to randomised controlled trials (RCTs) can be challenging, with most trials not reaching recruitment targets. Randomised feasibility studies can be set up prior to a main trial to identify and overcome recruitment obstacles.
Samantha Husbands, Daisy Elliott, Tim R. C. Davis, Jane M. Blazeby, Eleanor F. Harrison, Alan A. Montgomery, Kirsty Sprange, Lelia Duley, Alexia Karantana, William Hollingworth, Nicola Mills   +10 more
doaj   +1 more source

The group-based social skills training SOSTA-FRA in children and adolescents with high functioning autism spectrum disorder - study protocol of the randomised, multi-centre controlled SOSTA - net trial [PDF]

, 2013
Background: Group-based social skills training (SST) has repeatedly been recommended as treatment of choice in high-functioning autism spectrum disorder (HFASD). To date, no sufficiently powered randomised controlled trial has been performed to establish
Bender, Stephan, Cholemkery, Hannah, Elsuni, Leyla, Freitag, Christine M., Kieser, Meinhard, Kroeger, Anne K., Kunz, Cornelia Ursula   +6 more
core   +1 more source

Exploring demographic and lifestyle associations with patient experience following telephone triage by a primary care doctor or nurse:secondary analyses from a cluster randomised controlled trial [PDF]

, 2015
The ESTEEM trial was a cluster randomised controlled trial that compared two telephone triage management systems (general practitioner (GP) or a nurse supported by computer decision support software) with usual care, in response to a request for same-day
Bunn, Campbell, Campbell, Campbell, Campbell, Kontopantelis, Lyratzopoulos, McKinstry, Mead, Murdoch, Murdoch, Paddison, Paddison, Richards, Richards, Salisbury, Stirewalt, van Uden, Warren   +18 more
core   +2 more sources

Seminal papers in urology: maintenance Bacillus Calmette-Guerin (BCG) immunotherapy for recurrent Ta, T1 and carcinoma in situ transitional cell carcinoma of the bladder: a randomized southwest oncology group study (SWOG-8507)

BMC Urology, 2023
The South West Oncology Group’s 2000 randomised-control trial investigated the addition of maintenance intravesical bacillus Calmette-Guerin (BCG) to non-muscle invasive urothelial carcinoma (NMIUC) treatment. The results were published when the efficacy
Jake Tempo, Damien Bolton, Michael O’Callaghan   +2 more
doaj   +1 more source