Results 1 to 10 of about 702,734 (359)

Physio4FMD: protocol for a multicentre randomised controlled trial of specialist physiotherapy for functional motor disorder [PDF]

BMC Neurology, 2019
Background Patients with functional motor disorder (FMD) experience persistent and disabling neurological symptoms such as weakness, tremor, dystonia and disordered gait.
Glenn Nielsen, Jon Stone, Marta Buszewicz, Alan Carson, Laura H. Goldstein, Kate Holt, Rachael Hunter, Jonathan Marsden, Louise Marston, Hayley Noble, Markus Reuber, Mark J. Edwards, on behalf of the Physio4FMD Collaborative Group   +12 more
doaj   +8 more sources

Randomised controlled trials are important [PDF]

BMJ, 1999
EDITOR—Cranberg's arguments against controlled trials and in favour of historical controls supported by data on matching for known risk factors are seriously flawed.1 There are at least four fallacies. Firstly, the matching procedures …
G. Venning
openalex   +5 more sources

Randomised controlled trials [PDF]

Archives of Disease in Childhood, 1997
Editor,—We read with interest the recent editorial on evidence-based child health.1 We were struck by how easy it is to overlook a randomised controlled trial (RCT) in the Archives (or any other journal) if this is not indicated in the title or abstract. We wondered if this was the …
Robert A. Phillips, Tamar Rothenberg
openaire   +5 more sources

The APPLE Tree programme: Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build REsiliEnce—randomised controlled trial

Trials, 2022
Background Large-scale trials of multidomain interventions show that modifying lifestyle and psychological risk factors can slow cognitive decline. We aim to determine if a lower intensity, personally tailored secondary dementia prevention programme for ...
M. Poppe, L. Duffy, N. L. Marchant, J. A. Barber, R. Hunter, N. Bass, A. M. Minihane, K. Walters, P. Higgs, P. Rapaport, I. A. Lang, S. Morgan-Trimmer, J. Huntley, Z. Walker, H. Brodaty, H. C. Kales, K. Ritchie, A. Burton, J. Wenborn, A. Betz, C. Cooper   +20 more
doaj   +1 more source

Adapting the randomised controlled trial (RCT) for precision medicine: introducing the nested-precision RCT (npRCT)

Trials, 2021
Adaptations to the gold standard randomised controlled trial (RCT) have been introduced to decrease trial costs and avoid high sample sizes. To facilitate development of precision medicine algorithms that aim to optimise treatment allocation for ...
Nils Kappelmann, Bertram Müller-Myhsok, Johannes Kopf-Beck   +2 more
doaj   +1 more source

Optimising recruitment to the HAND-1 RCT feasibility study: integration of the QuinteT Recruitment Intervention (QRI)

Pilot and Feasibility Studies, 2020
Background Recruitment to randomised controlled trials (RCTs) can be challenging, with most trials not reaching recruitment targets. Randomised feasibility studies can be set up prior to a main trial to identify and overcome recruitment obstacles.
Samantha Husbands, Daisy Elliott, Tim R. C. Davis, Jane M. Blazeby, Eleanor F. Harrison, Alan A. Montgomery, Kirsty Sprange, Lelia Duley, Alexia Karantana, William Hollingworth, Nicola Mills   +10 more
doaj   +1 more source

Randomised controlled trial of mesalazine in IBS [PDF]

Gut, 2014
Low-grade intestinal inflammation plays a role in the pathophysiology of IBS. In this trial, we aimed at evaluating the efficacy and safety of mesalazine in patients with IBS.We conducted a phase 3, multicentre, tertiary setting, randomised, double-blind, placebo-controlled trial in patients with Rome III confirmed IBS.
BARBARA, GIOVANNI, CREMON, CESARE, Annese, Vito, Basilisco, Guido, BAZZOLI, FRANCO, Bellini, Massimo, Benedetti, Antonio, Benini, Luigi, Bossa, Fabrizio, Buldrini, Paola, Cicala, Michele, Cuomo, Rosario, Germanà, Bastianello, Molteni, Paola, Neri, Matteo, Rodi, Marcello, Saggioro, Alfredo, Scribano, Maria Lia, Vecchi, Maurizio, Zoli, Giorgio, CORINALDESI, ROBERTO, STANGHELLINI, VINCENZO   +21 more
openaire   +8 more sources

The group-based social skills training SOSTA-FRA in children and adolescents with high functioning autism spectrum disorder - study protocol of the randomised, multi-centre controlled SOSTA - net trial [PDF]

, 2013
Background: Group-based social skills training (SST) has repeatedly been recommended as treatment of choice in high-functioning autism spectrum disorder (HFASD). To date, no sufficiently powered randomised controlled trial has been performed to establish
Bender, Stephan, Cholemkery, Hannah, Elsuni, Leyla, Freitag, Christine M., Kieser, Meinhard, Kroeger, Anne K., Kunz, Cornelia Ursula   +6 more
core   +1 more source

An intervention for people with learning disabilities and epilepsy [PDF]

, 2015
Date of Acceptance: 09/01/2015Epilepsy is relatively common in people with learning disabilities, and can be complex and refractory to treatment, with negative effects on quality of life and service costs.
Durand, Marie-Anne, Gates, Bob, Mengoni, Silvana   +2 more
core   +1 more source

Household costs of dengue illness: secondary outcomes from a randomised controlled trial of dengue prevention in Guerrero state, Mexico

BMC Public Health, 2017
Background Dengue is a serious public health problem with an important economic impact. This study used data from a cluster randomised controlled trial of community mobilisation for dengue prevention to estimate the household costs of treatment of dengue
José Legorreta-Soberanis, Sergio Paredes-Solís, Arcadio Morales-Pérez, Elizabeth Nava-Aguilera, Felipe René Serrano-de los Santos, Diana Lisseth Dimas-Garcia, Robert J Ledogar, Anne Cockcroft, Neil Andersson   +8 more
doaj   +1 more source