Results 1 to 10 of about 1,276,514 (361)

Randomised controlled trials [PDF]

open access: yesArchives of Disease in Childhood, 1997
Editor,—We read with interest the recent editorial on evidence-based child health.1 We were struck by how easy it is to overlook a randomised controlled trial (RCT) in the Archives (or any other journal) if this is not indicated in the title or abstract. We wondered if this was the …
Robert A. Phillips, Tamar Rothenberg
openaire   +5 more sources

The APPLE Tree programme: Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build REsiliEnce—randomised controlled trial

open access: yesTrials, 2022
Background Large-scale trials of multidomain interventions show that modifying lifestyle and psychological risk factors can slow cognitive decline. We aim to determine if a lower intensity, personally tailored secondary dementia prevention programme for ...
M. Poppe   +20 more
doaj   +1 more source

Adapting the randomised controlled trial (RCT) for precision medicine: introducing the nested-precision RCT (npRCT)

open access: yesTrials, 2021
Adaptations to the gold standard randomised controlled trial (RCT) have been introduced to decrease trial costs and avoid high sample sizes. To facilitate development of precision medicine algorithms that aim to optimise treatment allocation for ...
Nils Kappelmann   +2 more
doaj   +1 more source

Optimising recruitment to the HAND-1 RCT feasibility study: integration of the QuinteT Recruitment Intervention (QRI)

open access: yesPilot and Feasibility Studies, 2020
Background Recruitment to randomised controlled trials (RCTs) can be challenging, with most trials not reaching recruitment targets. Randomised feasibility studies can be set up prior to a main trial to identify and overcome recruitment obstacles.
Samantha Husbands   +10 more
doaj   +1 more source

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis

open access: yesmedRxiv, 2022
Background: We evaluated the use of baricitinib, a Janus kinase (JAK) 1/2 inhibitor, for the treatment of patients admitted to hospital because of COVID-19.
O. Abani   +499 more
semanticscholar   +1 more source

Randomised controlled trial of mesalazine in IBS [PDF]

open access: yesGut, 2014
Low-grade intestinal inflammation plays a role in the pathophysiology of IBS. In this trial, we aimed at evaluating the efficacy and safety of mesalazine in patients with IBS.We conducted a phase 3, multicentre, tertiary setting, randomised, double-blind, placebo-controlled trial in patients with Rome III confirmed IBS.
BARBARA, GIOVANNI   +21 more
openaire   +8 more sources

Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial

open access: yesBritish medical journal, 2020
Objective To assess the efficacy and safety of hydroxychloroquine plus standard of care compared with standard of care alone in adults with coronavirus disease 2019 (covid-19). Design Multicentre, open label, randomised controlled trial.
Wei Tang   +23 more
semanticscholar   +1 more source

Household costs of dengue illness: secondary outcomes from a randomised controlled trial of dengue prevention in Guerrero state, Mexico

open access: yesBMC Public Health, 2017
Background Dengue is a serious public health problem with an important economic impact. This study used data from a cluster randomised controlled trial of community mobilisation for dengue prevention to estimate the household costs of treatment of dengue
José Legorreta-Soberanis   +8 more
doaj   +1 more source

Seminal papers in urology: maintenance Bacillus Calmette-Guerin (BCG) immunotherapy for recurrent Ta, T1 and carcinoma in situ transitional cell carcinoma of the bladder: a randomized southwest oncology group study (SWOG-8507)

open access: yesBMC Urology, 2023
The South West Oncology Group’s 2000 randomised-control trial investigated the addition of maintenance intravesical bacillus Calmette-Guerin (BCG) to non-muscle invasive urothelial carcinoma (NMIUC) treatment. The results were published when the efficacy
Jake Tempo   +2 more
doaj   +1 more source

Patch: platelet transfusion in cerebral haemorrhage: study protocol for a multicentre, randomised, controlled trial

open access: yesBMC Neurology, 2010
BackgroundPatients suffering from intracerebral haemorrhage have a poor prognosis, especially if they are using antiplatelet therapy. Currently, no effective acute treatment option for intracerebral haemorrhage exists.
Koen de Gans   +7 more
semanticscholar   +1 more source

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