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Randomised controlled trials [PDF]
Archives of Disease in Childhood, 1997 Editor,—We read with interest the recent editorial on evidence-based child health.1 We were struck by how easy it is to overlook a randomised controlled trial (RCT) in the Archives (or any other journal) if this is not indicated in the title or abstract. We wondered if this was the …Robert A. Phillips, Tamar Rothenbergopenaire +5 more sourcesThe APPLE Tree programme: Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build REsiliEnce—randomised controlled trial
Trials, 2022 Background Large-scale trials of multidomain interventions show that modifying lifestyle and psychological risk factors can slow cognitive decline. We aim to determine if a lower intensity, personally tailored secondary dementia prevention programme for ...M. Poppe, L. Duffy, N. L. Marchant, J. A. Barber, R. Hunter, N. Bass, A. M. Minihane, K. Walters, P. Higgs, P. Rapaport, I. A. Lang, S. Morgan-Trimmer, J. Huntley, Z. Walker, H. Brodaty, H. C. Kales, K. Ritchie, A. Burton, J. Wenborn, A. Betz, C. Cooper +20 moredoaj +1 more sourceOptimising recruitment to the HAND-1 RCT feasibility study: integration of the QuinteT Recruitment Intervention (QRI)
Pilot and Feasibility Studies, 2020 Background Recruitment to randomised controlled trials (RCTs) can be challenging, with most trials not reaching recruitment targets. Randomised feasibility studies can be set up prior to a main trial to identify and overcome recruitment obstacles.Samantha Husbands, Daisy Elliott, Tim R. C. Davis, Jane M. Blazeby, Eleanor F. Harrison, Alan A. Montgomery, Kirsty Sprange, Lelia Duley, Alexia Karantana, William Hollingworth, Nicola Mills +10 moredoaj +1 more sourceBaricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis
medRxiv, 2022 Background: We evaluated the use of baricitinib, a Janus kinase (JAK) 1/2 inhibitor, for the treatment of patients admitted to hospital because of COVID-19.O. Abani, A. Abbas, F. Abbas, J. Abbas, K. Abbas, M. Abbas, Sadia Abbasi, H. Abbass, A. Abbott, A. Abbott, N. Abdallah, Ammar Abdelaziz, A. Abdelaziz, M. Abdelfattah, B. Abdelqader, A. Abdul, B. Abdul, S. Abdul, A. A. Rasheed, A. Abdulakeem, R. Abdul-Kadir, A. Abdullah, A. Abdulmumeen, R. Abdul-Raheem, N. Abdulshukkoor, K. Abdusamad, Y. A. E. Khaleq, M. Abedalla, Abeer Abeer Ul Amna, Lynn Abel, K. Abernethy, M. Abeywickrema, C. Abhinaya, A. Abidin, A. Aboaba, A. Aboagye-Odei, H. Aboelela, H. Abo-Leyah, K. Abouelela, A. Abou-Haggar, M. Abouibrahim, Ahmed Abousamra, M. Abouzaid, M. Abraham, T. Abraham, A. Abraheem, J. Abrams, R. Abrams, Hyacinth-John Abu, A. Abu-Arafeh, S. M. Abubacker, A. Abung, Y. Abusamra, Y. Aceampong, A. Achara, D. Acharya, P. Acheampong, S. Acheampong, J. Acheson, S. Achieng, A. Acosta, R. Acquah, C. Acton, J. Adabie-Ankrah, P. Adair, F. Adam, M. Adam, H. Adamali, M. Adamczyk, C. Adams, C. Adams, Daniella Adams, K. Adams, L. Adams, N. Adams, R. Adams, T. Adams, L. Adamu-Ikeme, K. Adatia, K. Adcock, A. Addo, O. Adeagbo, A. Adebiyi, O. Adedeji, Y. Adegeye, K. Adegoke, V. Adell, Sherna F. Adenwalla, F. Adeoye, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, A. Adeyanju, J. Adeyemi, T. Adeyemo, B. Adhikari, R. Adhikary, A. Aditya, G. Adkins, A. Adnan, J. Aeron-Thomas, D. Affleck, C. Afnan, M. Afridi, Z. Aftab, Meenakshi Agarwal, R. Agbeko, C. Agbo, S. Aggarwal, A. Aghababaie, L. Jimenez, Shafana Ahamed Sadiq, M. Nazeer, Mohammad Ahmad, S. Ahmad, Afshan Ahmed, Ashar E. Ahmed, A. Ahmed, B. Ahmed, Bilal Ahmed, F. Ahmed, H. Ahmed, H. Ahmed, I. Ahmed, Khaled Ahmed, K. Ahmed, L. Ahmed, Mahin Ahmed, Maria C Ahmed, Muhammad S Ahmed, Naseer Ahmed, N. Ahmed, O. Ahmed, R. Ahmed, Rawya Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sana G Ahmed, S. Ahmed, S. Ahmed, R. Ali, B. Mohamud, Sana G Ahmed, S. Ahmer, A. Ahonia, C. Aiken, D. Ail, M. Ainsworth, M. Aissa, L. Aitken, B. Ajay, A. Ajibode, A. Ajmi, N. Akhtar, N. Akhtar, S. Akili, B. Akinbiyi, O. Akindolie, Y. Akinfenwa, O. Akinkugbe, I. Akinpelu, Mohammad Akram, O. Aktinade, U. Akudi, Ahmad S A R Al Aaraj, Asma Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, E. Al-Abadi, A. Alabi, N. Aladangady, M. Alafifi, A. Alam, S. Alam, A. Al-Asadi, K. Alatzoglou, P. Albert, L. Albon, A. Alcalá, G. Alcorn, S. Alcorn, A. Aldana, D. Alderdice, A. Aldesouki, R. Aldouri, J. Aldridge, N. Aldridge, R. M. Ale, A. Alegria, A. Alexander, Courtney M Alexander, J. Alexander, Peter D G Alexander, J. Al-fori, L. Alghazawi, O. Alhabsha, B. Al-Hakim, R. Alhameed, M. Al-Hayali, S. Al-Hity, Ali Ali, Amanda Ali, Asad Ali, Fawzia R Ali, J. Ali, Mariam Ali, Mohamed Ali, Mohammad Ali, Muhammad Ishtiaq Ali, Nayab Ali, O. Ali, Ramla Ali, Sakina Ali, Syed Ali, E. Aliberti, J. Alin, A. Alina, A. Alipustain, F. Aliyuda, K. Alizadeh, M. Al-Jibury, S. Al-Juboori, M. Al-Khalil, A. Alkhudhayri, M. Alkhusheh, F. Allan, N. Allan, A. Allanson, R. Allcock, E. Allen, J. Allen, K. Allen, L. Allen, P. Allen, R. Allen, S. Allen, Sharon A. Allen, S. Allen, Tania Allen, A. Alli, K. Allison, B. Allman, Helen K Allsop, L. Allsop, D. Allsup, Amal F T Almahroos, H. Al-Moasseb, M. Al-Obaidi, L. Alomari, A. Al-Rabahi, B. Al-Ramadhani, Z. Al-Saadi, R. Al-Sammarraie, I. Alshaer, R. Salman, W. Al-Shamkhani, F. Alsheikh, B. Al-Sheklly, S. Altaf, A. Alty, M. Alvarez, Maria Alvarez Corral, E. Alveyn, M. Alzetani, S. Amamou, N. Amar, S. Ambalavanan, R. Ambrogetti, Chris Ambrose, A. Ameen, K. Ames, M. Amezaga, A. Amin, Amina Amin, K. Amin, S. Amin, T. Amin, B. Amit, A. Amjad, N. Amjad, V. Amosun, M. Amsal, K. Amsha, N. Martin, P. Amy, A. Anada, A. Anand, S. Anandappa, Satya D Anantapatnaikuni, Ellen Anderson, Julie Anderson, L. Anderson, Marina Anderson, Michelle Anderson, N. Anderson, R. Anderson, R. Anderson, Rory Anderson, S. Anderson, Wendy Anderson, P. Andreou, A. Andrews, Antonette Andrews, Jill Andrews, Joyann Andrews, K. Aneke, A. Ang, W. W. Ang, T. Angel, A. Angela, P. Angelini, L. Anguvaa, O. Anichtchik, M. Anim-Somuah, K. Aniruddhan, J. Annett, L. Anning, Patrick J Anstey, R. Anstey, A. Anthony, A. Anthony-Pillai, P. Antill, Z. Antonina, V. Anu, M. Anwar, E. Apetri, A. Apostolopoulos, S. Appleby, D. Appleyard, M. Aquino, B. Araba, S. Aransiola, M. Araujo, A. Archer, D. Archer, S. Archer, Simon Archer, D. Arcoria, C. Ardley, A. Arias, O. Aribike, R. Arimoto, C. Arkley, C. Armah, I. Armata, J. Armistead, A. Armitage, C. Armstrong, M. Armstrong, S. Armstrong, W. Armstrong, P. Armtrong, H. Arndt, C. Arnison-Newgass, D. Arnold, R. Arnold, A. Arnott, D. Arora, K. Arora, P. Arora, R. Arora, A. Arter, A. Arumaithurai, A. Arya, R. Arya, D. Asandei, A. Asghar, M. Asghar, A. Ashab, C. Ashbrook-Raby, H. Ashby, J. Ashcroft, J. Ashcroft, S. Ashcroft, G. Asher, Z. Ashfak, Ayesha Binte Ashfaq, A. Ashish, D. Ashley, S. Ashman-Flavell, S. Ashok, A. Ashour, M. Ashraf, Saima Ashraf, Mohammad B Ashraq, D. Ashton, S. Ashton, A. Ashworth, F. Ashworth, R. Ashworth, A. Aslam, I. Aslam, Suhail Aslam, L. Aslett, H. Asogan, A. Asrar, Omar Assaf, R. Astin-Chamberlain, D. Athorne, B. Atkins, C. Atkins, S. Atkins, J. Atkinson, V. Atkinson, A. Atomode, B. Atraskiewicz, A. A. Attia, E. Attubato, M. Attwood, P. Aubrey, Z. Auer, A. Aujayeb, A. C. L. Aung, H. Aung, H. Aung, K. K. Aung, K. T. Aung, N. Aung, Y. Aung, Z. M. Aung, E. Austin, K. Austin, A. Auwal, M. Avari, M. Avery, N. Aveyard, J. Avis, G. Aviss, C. Avram, P. Avram, A. Awadelkareem, G. Awadzi, M. Awaly, A. Awan, A. Aya, E. Ayaz, A. Ayers, J. Azam, A. Azeem, M. Azharuddin, Ammar Aziz, Ghazala Aziz, Imran Aziz, N. Aziz, A. Azkoul, A. Shah, G. Azzopardi, H. Azzoug, F. Babatunde, Melvin Babi, B. Babiker, G. Babington, M. Babirecki, M. Babores, Adetona O Babs-Osibodu, S. Bacciarelli, R. Bachar, M. Bachour, G. Bacon, J. Bacon, B. Badal, M. Bader, Gurpreet R Badhan, S. Badhrinarayanan, Joseph P Bae, A. Baggaley, A. Baggott, G. Bagley, D. Bagmane, L. Bagshaw, K. Bahadori, A. Bailey, J. Bailey, K. Bailey, Lindsey K. Bailey, Liz Bailey, L. Bailey, M. Bailey, Morgan Bailey, Pippa K. Bailey, S. Bailey, H. Baillie, J. Baillie, J. Bain, V. Bains, D. Baird, E. Baird, K. Baird, S. Baird, T. Baird, Y. Baird, A. Bajandouh, D. C. Baker, E. Baker, Evelyn Baker, J. Baker, J. Baker, Kenneth Baker, M. Baker, Rebecca M. Baker +499 moresemanticscholar +1 more sourceRandomised controlled trial of mesalazine in IBS [PDF]
Gut, 2014 Low-grade intestinal inflammation plays a role in the pathophysiology of IBS. In this trial, we aimed at evaluating the efficacy and safety of mesalazine in patients with IBS.We conducted a phase 3, multicentre, tertiary setting, randomised, double-blind, placebo-controlled trial in patients with Rome III confirmed IBS.BARBARA, GIOVANNI, CREMON, CESARE, Annese, Vito, Basilisco, Guido, BAZZOLI, FRANCO, Bellini, Massimo, Benedetti, Antonio, Benini, Luigi, Bossa, Fabrizio, Buldrini, Paola, Cicala, Michele, Cuomo, Rosario, Germanà, Bastianello, Molteni, Paola, Neri, Matteo, Rodi, Marcello, Saggioro, Alfredo, Scribano, Maria Lia, Vecchi, Maurizio, Zoli, Giorgio, CORINALDESI, ROBERTO, STANGHELLINI, VINCENZO +21 moreopenaire +8 more sourcesHydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial
British medical journal, 2020 Objective To assess the efficacy and safety of hydroxychloroquine plus standard of care compared with standard of care alone in adults with coronavirus disease 2019 (covid-19). Design Multicentre, open label, randomised controlled trial.Wei Tang, Z. Cao, Mingfeng Han, Zhengyan Wang, Junwen Chen, Wenjin Sun, Yaojie Wu, W. Xiao, Shengyong Liu, E. Chen, Wei Chen, Xiongbiao Wang, Jiuyong Yang, Jun Lin, Qing-xia Zhao, You-qin Yan, Zhibin Xie, Dan-Qi Li, Yaofeng Yang, Leshan Liu, J. Qu, G. Ning, G. Shi, Q. Xie +23 moresemanticscholar +1 more sourceHousehold costs of dengue illness: secondary outcomes from a randomised controlled trial of dengue prevention in Guerrero state, Mexico
BMC Public Health, 2017 Background Dengue is a serious public health problem with an important economic impact. This study used data from a cluster randomised controlled trial of community mobilisation for dengue prevention to estimate the household costs of treatment of dengue José Legorreta-Soberanis, Sergio Paredes-Solís, Arcadio Morales-Pérez, Elizabeth Nava-Aguilera, Felipe René Serrano-de los Santos, Diana Lisseth Dimas-Garcia, Robert J Ledogar, Anne Cockcroft, Neil Andersson +8 moredoaj +1 more sourcePatch: platelet transfusion in cerebral haemorrhage: study protocol for a multicentre, randomised, controlled trial
BMC Neurology, 2010 BackgroundPatients suffering from intracerebral haemorrhage have a poor prognosis, especially if they are using antiplatelet therapy. Currently, no effective acute treatment option for intracerebral haemorrhage exists.Koen de Gans, R. J. de Haan, C. Majoie, Maria M Koopman, A. Brand, M. G. Dijkgraaf, M. Vermeulen, Y. Roos +7 moresemanticscholar +1 more source
