Results 11 to 20 of about 667,561 (138)

Fish oil (n-3 fatty acids) in drug resistant epilepsy: a randomised placebo-controlled crossover study. [PDF]

, 2014
Backgroundn-3 fatty acids inhibit neuronal excitability and reduce seizures in animal models. High-dose fish oil has been explored in two randomised trials in drug resistant epilepsy with negative results.
DeGiorgio, Christopher M, Gornbein, Jeffrey, Harper, Ronald, Meymandi, Sheba, Miller, Patrick R, Schrader, Lara, Soss, Jason   +6 more
core   +1 more source

Non-strategic ignorance: Considering the potential for a paradigm shift in evidence-based mental health [PDF]

, 2018
Randomised controlled trials form a central building block within the prevailing evidence-based mental health paradigm. Both methodology and paradigm have been widely problematised since their emergence in the mid-late twentieth century.
Cochrane A, Department of Health, Department of Health, Department of Health, Department of Health, Felicitas Rost, Kleinman A, Kuhn T, Latour B, Maxine Dennis, Richardson PH, Sukhjit Sidhu, Susan McPherson   +12 more
core   +1 more source

A pragmatic randomised controlled trial comparing the efficacy of a femoral nerve block and periarticular infiltration for early pain relief following total knee arthroplasty [PDF]

, 2017
Aims The aim of this study was to compare the effectiveness of a femoral nerve block and a periarticular infiltration in the management of early post-operative pain after total knee arthroplasty (TKA).
Achten, Juul, Balasubramanian, S., Costa, Matthew L., Parsons, Helen, Parsons, Nicholas R., Sprowson, A. P., Thompson, P., Wall, Peter D. H.   +7 more
core   +2 more sources

Website of the week: Randomised controlled trials [PDF]

BMJ, 1999
This week, a series of four articles considers the place of the randomised controlled trial as we approach the second century of experience with the concept. Its basic principle is genuine uncertainty as to which treatment arm of the trial it would be in a patient's best interests to enter. This is not necessarily an easy concept to transmit, …
openaire   +3 more sources

Limitations of randomised controlled trials [PDF]

BMJ, 1995
EDITOR,—T C B Dehn has commented on the problems of accruing patients into randomised controlled trials, noting the understandable reluctance of patients to enter some trials (“I want the best treatment, doctor”) in which the patient's outcome (for example, time to death) is the main end point and, consequently, the patient is unable to benefit from ...
R. H. Grace, Rosemary Hittinger, L P Fielding   +2 more
openaire   +2 more sources

Lovastatin for adult patients with dengue: protocol for a randomised controlled trial. [PDF]

, 2012
BACKGROUND: Dengue is the most important vector-borne viral infection of man, with approximately 2 billion people living in areas at risk. Infection results in a range of manifestations from asymptomatic infection through to life-threatening shock and ...
Dung, Nguyen Thi Phuong, Farrar, Jeremy, Hien, Tran Tinh, Merson, Laura, Peeling, Rosanna, Simmons, Cameron, Tai, Luong Thi Hue, Truong, Nguyen Thanh, Van Hao, Nguyen, Van Vinh Chau, Nguyen, Whitehorn, James, Wills, Bridget, Wolbers, Marcel   +12 more
core   +1 more source

Optimal design for on-farm strip trials -- systematic or randomised? [PDF]

arXiv, 2022
There is no doubt on the importance of randomisation in agricultural experiments by agronomists and biometricians. Even when agronomists extend the experimentation from small trials to large on-farm trials, randomised designs predominate over systematic designs.
arxiv  

Pharmacist-led management of chronic pain in primary care:costs and benefits in a pilot randomised controlled trial [PDF]

, 2015
To explore differences in mean costs (from a UK National Health Service perspective) and effects of pharmacist-led management of chronic pain in primary care evaluated in a pilot randomised controlled trial (RCT), and to estimate optimal sample size for ...
Barton, Brazier, Breivik, Breivik, Briggs, Bruhn, Classification of chronic pain, Curtis, Elliott, Gaskin, Glick, Grieve, Harrison, Herdman, Janssen, Johnsen, Johnsen, Maniadkis, National Institute for Health and Clinical Excellence, Obradovic, Royal Pharmaceutical Society of Great Britain, Rubin, Rubin, Scottish Intercollegiate Guidelines Network (SIGN), Stewart, Søgaard, Torrance, Whitehurst, Willan, Willan   +29 more
core   +1 more source

A novel estimand to adjust for rescue treatment in clinical trials [PDF]

, 2020
The interpretation of randomised clinical trial results is often complicated by intercurrent events. For instance, rescue medication is sometimes given to patients in response to worsening of their disease, either in addition to the randomised treatment or in its place. The use of such medication complicates the interpretation of the intention-to-treat
arxiv   +1 more source

A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol [PDF]

, 2019
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease that causes breathlessness and cough that worsen over time, limiting daily activities and negatively impacting quality of life.
Allgar, V., Cohen, J. F., Crooks, M. G., Dyson, J., English, A., Hargreaves, I., Hart, S., Hussain, J., Johnson, M., Richardson, G., Swan, F., Twiddy, M., Wright, C.   +12 more
core   +3 more sources