Results 11 to 20 of about 760,498 (359)

Lovastatin for adult patients with dengue: protocol for a randomised controlled trial. [PDF]

, 2012
BACKGROUND: Dengue is the most important vector-borne viral infection of man, with approximately 2 billion people living in areas at risk. Infection results in a range of manifestations from asymptomatic infection through to life-threatening shock and ...
Dung, Nguyen Thi Phuong, Farrar, Jeremy, Hien, Tran Tinh, Merson, Laura, Peeling, Rosanna, Simmons, Cameron, Tai, Luong Thi Hue, Truong, Nguyen Thanh, Van Hao, Nguyen, Van Vinh Chau, Nguyen, Whitehorn, James, Wills, Bridget, Wolbers, Marcel   +12 more
core   +1 more source

Household costs of dengue illness: secondary outcomes from a randomised controlled trial of dengue prevention in Guerrero state, Mexico

BMC Public Health, 2017
Background Dengue is a serious public health problem with an important economic impact. This study used data from a cluster randomised controlled trial of community mobilisation for dengue prevention to estimate the household costs of treatment of dengue
José Legorreta-Soberanis, Sergio Paredes-Solís, Arcadio Morales-Pérez, Elizabeth Nava-Aguilera, Felipe René Serrano-de los Santos, Diana Lisseth Dimas-Garcia, Robert J Ledogar, Anne Cockcroft, Neil Andersson   +8 more
doaj   +1 more source

Thinking territory historically. [PDF]

, 2010
BACKGROUND: While the randomised controlled trial (RCT) is generally regarded as the design of choice for assessing the effects of health care, within the social sciences there is considerable debate about the relative suitability of RCTs and non ...
Bagnall, A, Colquitt, J, Dinnes, J, Garrett, Z, Oliver, K, Oliver, S, Rees, R, Shepherd, J, Sowden, A, Thomas, J, White, I   +10 more
core   +1 more source

Understanding randomised controlled trials [PDF]

Archives of Disease in Childhood, 2005
The hierarchy of evidence in assessing the effectiveness of interventions or treatments is explained, and the gold standard for evaluating the effectiveness of interventions, the randomised controlled trial, is discussed. Issues that need to be considered during the critical appraisal of randomised controlled trials, such as assessing the validity of ...
openaire   +2 more sources

The CRASH trial: the first large-scale, randomised, controlled trial in head injury. [PDF]

, 2001
The global epidemic of head injuries is just beginning. Many are caused by road traffic crashes. It is estimated that, by 2020, road traffic crashes will have moved from its present position of ninth to third in the world disease burden ranking, as ...
Roberts, I
core   +2 more sources

Fish oil (n-3 fatty acids) in drug resistant epilepsy: a randomised placebo-controlled crossover study. [PDF]

, 2014
Backgroundn-3 fatty acids inhibit neuronal excitability and reduce seizures in animal models. High-dose fish oil has been explored in two randomised trials in drug resistant epilepsy with negative results.
DeGiorgio, Christopher M, Gornbein, Jeffrey, Harper, Ronald, Meymandi, Sheba, Miller, Patrick R, Schrader, Lara, Soss, Jason   +6 more
core   +1 more source

Enhancing Recruitment Using Teleconference and Commitment Contract (ERUTECC): study protocol for a randomised, stepped-wedge cluster trial within the EFFECTS trial

Trials, 2018
Background Many randomised controlled trials (RCTs) fail to meet their recruitment goals in time. Trialists are advised to include study recruitment strategies within their trials. EFFECTS is a Swedish, academic-led RCT of fluoxetine for stroke recovery.
Erik Lundström, Eva Isaksson, Per Wester, Ann-Charlotte Laska, Per Näsman   +4 more
doaj   +1 more source

Latch On: A protocol for a multi-centre, randomised controlled trial of perinatal support to improve breastfeeding outcomes in women with a raised BMI

Contemporary Clinical Trials Communications, 2021
Introduction: Breastfeeding is associated with improved maternal and child outcomes. Women with a higher body mass index (BMI), who comprise about 50% of the population, are at increased risk of poorer breastfeeding practices and are a population who ...
Sharleen L. O'Reilly, Eileen C. O'Brien, Denise McGuinness, John Mehegan, Barbara Coughlan, Denise O'Brien, Marcelina Szafranska, Sophie Callanan, Shenda Hughes, Marie C. Conway, Mary Brosnan, Lucille Sheehy, Rosie Murtagh, Lorraine O'Hagan, Stephanie Murray, Charmaine Scallon, Elizabeth Dunn, Paula Power, Marie Woodcock, Amy Carroll, Marie Corbett, Michelle Walsh, Regina Keogh, Fionnuala M. McAuliffe   +23 more
doaj   +1 more source

Using pens as an incentive for trial recruitment of older adults: An embedded randomised controlled trial [version 1; peer review: 2 approved]

F1000Research, 2019
Background: Meeting recruitment targets for randomised controlled trials is challenging.  This trial evaluated the effectiveness of including a pen within the trial invitation pack on the recruitment of older adults into a randomised controlled trial ...
Katie Whiteside, Lydia Flett, Alex Mitchell, Caroline Fairhurst, Sarah Cockayne, Sara Rodgers, David Torgerson, OTIS Study Group   +7 more
doaj   +1 more source

Non-strategic ignorance: Considering the potential for a paradigm shift in evidence-based mental health [PDF]

, 2018
Randomised controlled trials form a central building block within the prevailing evidence-based mental health paradigm. Both methodology and paradigm have been widely problematised since their emergence in the mid-late twentieth century.
Cochrane A, Department of Health, Department of Health, Department of Health, Department of Health, Felicitas Rost, Kleinman A, Kuhn T, Latour B, Maxine Dennis, Richardson PH, Sukhjit Sidhu, Susan McPherson   +12 more
core   +1 more source