Results 21 to 30 of about 760,498 (359)

Learning from OCTET – exploring the acceptability of clinical trials management methods

Trials, 2018
Background Conducting research can be time consuming, difficult and challenging. Guidance and pragmatic advice focussing on randomised controlled trial conduct are available but do not necessarily constitute comprehensive guidance.
Catherine Arundel, Judith Gellatly
doaj   +1 more source

A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)

Research Integrity and Peer Review, 2019
Background The ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the ...
Kaitlyn Hair, Malcolm R. Macleod, Emily S. Sena, on behalf of the IICARus Collaboration   +3 more
doaj   +1 more source

The impact of video gaming on cognitive functioning of people with schizophrenia (GAME-S): study protocol of a randomised controlled trial

BMC Psychiatry, 2021
Background Video gaming is a promising intervention for cognitive and social impairment in patients with schizophrenia. A number of gaming interventions have been evaluated in small-scale studies with various patient groups, but studies on patients with ...
Maritta Välimäki, Min Yang, Yuen Ting Joyce Lam, Tella Lantta, Matias Palva, Satu Palva, Benjamin Yee, Siu Hung Yip, Kin-sun Dan Yu, Hing Chiu Charles Chang, Po Yee Ivy Cheng, Daniel Bressington   +11 more
doaj   +1 more source

Factors influencing participation in randomised clinical trials among patients with early Barrett’s neoplasia: a multicentre interview study

BMJ Open, 2023
Objectives Strong recruitment and retention into randomised controlled trials involving invasive therapies is a matter of priority to ensure better achievement of trial aims.
Pradeep Bhandari, Laurence B Lovat, Rehan Haidry, Krish Ragunath, Hugh Barr, Clive Stokes, Mohammad Farhad Peerally, Howard Smart, John De Caestecker, Clare Jackson   +9 more
doaj   +1 more source

Trial of Acute Femoral Fracture Fixation (TrAFFix): study protocol for a randomised controlled feasibility trial

Trials, 2017
Background Distal femoral fractures are a source of considerable morbidity and best treatment is currently uncertain. The Trial of Acute Femoral Fracture Fixation (TrAFFix) is a randomised, parallel-group feasibility study designed to inform the design ...
Xavier L. Griffin, Matthew L. Costa, Juul Achten, Melina Dritsaki, Janis Baird, Nicholas Parsons   +5 more
doaj   +1 more source

A systematic review of randomised controlled trials on the effectiveness of exercise programs on lumbo pelvic pain among postnatal women [PDF]

, 2015
Background: A substantial number of women tend to be affected by Lumbo Pelvic Pain (LPP) following child birth. Physical exercise is indicated as a beneficial method to relieve LPP, but individual studies appear to suggest mixed findings about its ...
A Garshasbi, A Gutke, A Gutke, A Gutke, A Gutke, A Tanvi, A Vleeming, AB Granath, AG Cramp, B Stuge, B Stuge, C Richardson, CB Olsson, CB Olsson, CD Skaggs, CF Yan, CG Maher, DB Stapleton, E Kontopantelis, E Líndal, E Thorell, EC Larsen, EK Bjelland, HM McCormack, HS Robinson, HS Robinson, HY Chang, I Mogren, IM Mogren, J Walker, JM Kendall, JM Mens, JM Mens, K Björklund, K Gjestland, L Nilsson-Wikmar, L Nilsson‐Wikmar, L Norén, M Kumle, M Perry, MA Mohseni-Bandpei, Meei-Ling Gau, NA Al‐Sayegh, NC Foley, NK Vøllestad, NN Ansari, O Airaksinen, O Ayanniyi, Pei-Ching Tseng, S Chaudry, S Malmqvist, SA Olivo, Shuby Puthussery, SM Wang, WWK To, Y Ko, Yannis Pappas, YL Ko   +57 more
core   +2 more sources

The SMILES trial: an important first step

BMC Medicine, 2018
The SMILES trial was the first intervention study to test dietary improvement as a treatment strategy for depression. Molendijk et al. propose that expectation bias and difficulties with blinding might account for the large effect size.
Felice N. Jacka, Adrienne O’Neil, Catherine Itsiopoulos, Rachelle Opie, Sue Cotton, Mohammadreza Mohebbi, David Castle, Sarah Dash, Cathrine Mihalopoulos, Mary Lou Chatterton, Laima Brazionis, Olivia M. Dean, Allison Hodge, Michael Berk   +13 more
doaj   +1 more source

Effect of a machine learning-based severe sepsis prediction algorithm on patient survival and hospital length of stay: a randomised clinical trial. [PDF]

, 2017
IntroductionSeveral methods have been developed to electronically monitor patients for severe sepsis, but few provide predictive capabilities to enable early intervention; furthermore, no severe sepsis prediction systems have been previously validated in
Barton, Christopher W, Das, Ritankar, Feldman, Mitchell D, Mataraso, Samson J, Shimabukuro, David W   +4 more
core   +2 more sources

Manual-assisted cognitive therapy for self-harm in personality disorder and substance misuse: a feasibility trial [PDF]

, 2014
<b>Aims and method</b> To assess the feasibility of conducting a larger, definitive randomised controlled trial of manual-assisted cognitive therapy (MACT), a brief focused therapy to address self-harm and promote engagement in services.
Brown, Tom M., Davidson, Kate M., James, Vairi, Kirk, Jamie, Richardson, Julie   +4 more
core   +1 more source

Factors associated with recruitment to randomised controlled trials in general practice: protocol for a systematic review

Trials, 2019
Background Randomised controlled trials (RCTs) are frequently unable to recruit sufficient numbers of participants. This affects the trial’s ability to answer the proposed research question, wastes resources and can be unethical.
Keith R. Moffat, Paul Cannon, Wen Shi, Frank Sullivan   +3 more
doaj   +1 more source