Results 91 to 100 of about 4,120,157 (359)

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Randomized phase II study comparing two doses of regorafenib in second-line treatment for advanced hepatocellular carcinoma

JHEP Reports
Background & Aims: The RESORCE trial confirmed regorafenib as a second-line treatment for advanced hepatocellular carcinoma (HCC) in patients who tolerated sorafenib.
Keisuke Koroki, Sadahisa Ogasawara, Sae Yumita, Miyuki Nakagawa, Hiroaki Kanzaki, Kazufumi Kobayashi, Masanori Inoue, Masato Nakamura, Naoya Kanogawa, Takayuki Kondo, Eiichiro Suzuki, Yoshihiko Ooka, Shingo Nakamoto, Yuki Shiko, Yoshihito Ozawa, Yosuke Inaba   +15 more
doaj   +1 more source

Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial

Trials, 2018
BackgroundIt had been more than 5 years since the first case of Middle East Respiratory Syndrome coronavirus infection (MERS-CoV) was recorded, but no specific treatment has been investigated in randomized clinical trials.
Yaseen M. Arabi, A. Alothman, H. Balkhy, A. Al-Dawood, Sameera M Aljohani, Shmeylan A. Al Harbi, S. Kojan, Majed Al Jeraisy, A. Deeb, A. Assiri, F. Al-Hameed, A. Alsaedi, Y. Mandourah, G. Almekhlafi, N. M. Sherbeeni, F. Elzein, Javed Memon, Yusri Taha, Abdullah Almotairi, Khalid A. Maghrabi, I. Qushmaq, A. Al bshabshe, A. Kharaba, S. Shalhoub, J. Jose, Robert A. Fowler, F. G. Hayden, Mohamed A. Hussein, Yaseen M. Adel Hanan H Abdulaziz Sameera Shmeylan Suleima Arabi Alothman Balkhy Al-Dawood AlJohani Al Harbi , Yaseen M. Arabi, A. Alothman, H. Balkhy, A. Al-Dawood, Sameera M Aljohani, Shmeylan A. Al Harbi, S. Kojan, Majed Al Jeraisy, A. Deeb, J. Jose, Mohamed A. Hussein, Mohammed Al Muhaidib, M. Sadat, H. Al Anizi, Reggie Dael, A. Assiri, Mohammad A. Almazroa, A. Asiri, Z. Memish, S. Ghazal, Sarah H. Alfaraj, Fahad Bafaqeeh, Abdulrahman Al Harthy, Mohammed Al Sulaiman, A. Mady, Y. Mandourah, G. Almekhlafi, N. M. Sherbeeni, F. Elzein, R. Muhammed, Shatha Al Samirrai, Shatha Awad, Rylen Cabio Cabal, A. Malibary, Bander Al Onazi, Maha Aljuhani, Melven Vince, Abdullah Almotairi, Mushira Al Enani, Alaa Alqurashi, Fatimah Alenezi, Nada M. Alkhani, Khalid A. Maghrabi, F. Al-Hameed, A. Alsaedi, A. Thaqafi, Ohoud Al Oraabi, Jalal Rifai, Pansy Elsamadisi, Medhat S. Hendy, S. Basher, Muhammed Abduldhaher, Wael Bajhamoum, I. Qushmaq, S. Shalhoub, Yusri Taha, Javed Memon, Shahinaz Bashir, I. Al-Dossary, Saleh Al Mekhloof, Bader Al-Muhainy, Shehab Suliman, M. Alshahrani, A. Al bshabshe, A. Kharaba, A. Al Jabri, Magdy F Farid, Alawi Alaidarous, Wael Alseraihi, H. Shahada, Jinish Shimi, S. Riaz, Bader Alharthi, Osama Yasin, Mohammad Khathlan, Robert A. Fowler, F. G. Hayden   +105 more
semanticscholar   +1 more source

Do inhaled beta-agonists control cough in URIs or acute bronchitis? [PDF]

, 2004
Patients who receive inhaled beta-agonists for cough due to acute upper respiratory infections (URI) are just as likely to report a productive cough at 7 days compared with patients treated with placebo (strength of recommendation [SOR]: A, based on a ...
Nashelsky, Joan, Stephens, Mary Maniscalco   +1 more
core  

Randomization Bias in Field Trials to Evaluate Targeting Methods

, 2018
This paper studies the evaluation of methods for targeting the allocation of limited resources to a high-risk subpopulation. We consider a randomized controlled trial to measure the difference in efficiency between two targeting methods and show that it ...
Potash, Eric
core   +1 more source

Yoga for generalized anxiety disorder: design of a randomized controlled clinical trial. [PDF]

, 2015
Generalized anxiety disorder (GAD) is a common disorder associated with significant distress and interference. Although cognitive behavioral therapy (CBT) has been shown to be the most effective form of psychotherapy, few patients receive or have access ...
Bui, Eric, Curtiss, Joshua, Hofmann, Stefan G., Hoge, Elizabeth, Keshaviah, Aparna, Khalsa, Sat Bir S., Rosenfield, David, Simon, Naomi   +7 more
core   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Estimating vaccine efficacy during open-label follow-up of COVID-19 vaccine trials based on population-level surveillance data

Epidemics
While rapid development and roll out of COVID-19 vaccines is necessary in a pandemic, the process limits the ability of clinical trials to assess longer-term vaccine efficacy. We leveraged COVID-19 surveillance data in the U.S.
Mia Moore, Yifan Zhu, Ian Hirsch, Tom White, Robert C. Reiner, Ryan M. Barber, David Pigott, James K. Collins, Serena Santoni, Magdalena E. Sobieszczyk, Holly Janes   +10 more
doaj   +1 more source

Occupational therapy predischarge home visits for patients with a stroke (HOVIS): results of a feasibility randomized controlled trial [PDF]

, 2013
Objective: To assess the feasibility of conducting a randomized controlled trial of occupational therapy predischarge home visits for people after stroke. Design: Randomized controlled trial and cohort study.
Drummond, A.E.R., Edwards, Claire, Fellows, K., Lincoln, Nadina, Sampson, Christopher James, Sprigg, Nikola, Whitehead, P.   +6 more
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source