Results 91 to 100 of about 4,106,658 (410)

Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma

open access: yesHepatology, 2002
This randomized, controlled trial assessed the efficacy of transarterial Lipiodol (Lipiodol Ultrafluide, Laboratoire Guerbet, Aulnay‐Sous‐Bois, France) chemoembolization in patients with unresectable hepatocellular carcinoma.
C. Lo   +7 more
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Sample size for a non-inferiority clinical trial with time-to-event data in the presence of competing risks [PDF]

open access: yesJournal of Biopharmaceutical Statistics, 2018, 28:797-807, 2018
The analysis and planning methods for competing risks model have been described in the literatures in recent decades, and non-inferiority clinical trials are helpful in current pharmaceutical practice. Analytical methods for non-inferiority clinical trials in the presence of competing risks were investigated by Parpia et al., who indicated that the ...
arxiv   +1 more source

A Randomized Controlled Trial [PDF]

open access: yes
Funding Information: This research was financed by national funds through the FCT\u2014Foundation for Science and Technology, I.P., under project 10.54499/UIDB/04585/2020.
Canales, Giancarlo De la Torre   +7 more
core   +1 more source

A randomized controlled clinical trial [PDF]

open access: yes, 2021
학위논문(석사) -- 서울대학교대학원 : 의과대학 의학과, 2021.8. 리우베이.Background: Platelet-rich plasma (PRP) has been applied as an adjuvant treatment of arthroscopic rotator cuff repair (ARCR) to enhance rotator cuff healing.
리우베이
core  

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Analysis of Randomized Controlled Trials [PDF]

open access: yesEpidemiologic Reviews, 2002
Although the sophistication and flexibility of the statistical technology available to the data analyst have increased, some durable, simple principles remain valid. Hypothesis-driven analyses, which were anticipated and specified in the protocol, must still be kept separate and privileged relative to the important, but risky data mining made possible ...
Peter Peduzzi   +4 more
openaire   +2 more sources

Efficacy and Tolerability of Long-Acting Injectable Naltrexone for Alcohol Dependence: A Randomized Controlled Trial

open access: yesGynecologic Oncology, 2005
OBJECTIVE The aim of this study was to assess the survival benefit of salvage surgical cytoreduction in patients with recurrent ovarian cancer and compare the surgical outcome with salvage chemotherapy alone.
M. Güngör   +5 more
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Cost-Effectiveness of Telemedicine in Remote Orthopedic Consultations: Randomized Controlled Trial

open access: yesJournal of Medical Internet Research, 2019
Background Telemedicine consultations using real-time videoconferencing has the potential to improve access and quality of care, avoid patient travels, and reduce health care costs. Objective The aim of this study was to examine the cost-effectiveness of
Astrid Buvik   +5 more
semanticscholar   +1 more source

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