Results 101 to 110 of about 4,008,309 (403)

Health Care Hotspotting - A Randomized, Controlled Trial.

New England Journal of Medicine, 2020
BACKGROUND There is widespread interest in programs aiming to reduce spending and improve health care quality among "superutilizers," patients with very high use of health care services.
Amy N. Finkelstein, Annetta Zhou, S. Taubman, J. Doyle   +3 more
semanticscholar   +1 more source

Tyranny of a "Randomized Controlled Trials"

Surgical Neurology International, 2012
“Evidence-based medicine” is a popular concept that simply means basing clinical decisions on best available scientific evidence. The idea appears very sensible and attractive – who would not want to be treated according to the best scientific evidence? As usual, complexity lurks just below the surface.
openaire   +4 more sources

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Prospective, double-blind, randomized controlled trial of electrophysiologically guided femoral nerve block in total knee arthroplasty

Therapeutics and Clinical Risk Management, 2013
Yoon Seok Youm,1 Sung Do Cho,1 Chang Ho Hwang21Department of Orthopedic Surgery, 2Department of Physical Medicine and Rehabilitation, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of KoreaBackground: The purpose of ...
Youm YS, Cho SD, Hwang CH
doaj  

Simvastatin treatment does not affect serum Vitamin D concentrations in patients with dyslipidemia: A randomized double-blind placebo-controlled cross-over trial

International Journal of Preventive Medicine, 2016
Background: Hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) are antihyperlipidemic drugs with an established efficacy in stabilizing atherosclerotic plaques and preventing atherogenesis and reducing cardiovascular events.
Mohsen Mazidi, Haleh Rokni, Amir Hossein Sahebkar, Akram Mohammadi, Majid Ghayour-Mobarhan, Gordon A Ferns   +5 more
doaj   +1 more source

Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial

Trials, 2018
BackgroundIt had been more than 5 years since the first case of Middle East Respiratory Syndrome coronavirus infection (MERS-CoV) was recorded, but no specific treatment has been investigated in randomized clinical trials.
Yaseen M. Arabi, A. Alothman, H. Balkhy, A. Al-Dawood, Sameera M Aljohani, Shmeylan A. Al Harbi, S. Kojan, Majed Al Jeraisy, A. Deeb, A. Assiri, F. Al-Hameed, A. Alsaedi, Y. Mandourah, G. Almekhlafi, N. M. Sherbeeni, F. Elzein, Javed Memon, Yusri Taha, Abdullah Almotairi, Khalid A. Maghrabi, I. Qushmaq, A. Al bshabshe, A. Kharaba, S. Shalhoub, J. Jose, Robert A. Fowler, F. G. Hayden, Mohamed A. Hussein, Yaseen M. Adel Hanan H Abdulaziz Sameera Shmeylan Suleima Arabi Alothman Balkhy Al-Dawood AlJohani Al Harbi , Yaseen M. Arabi, A. Alothman, H. Balkhy, A. Al-Dawood, Sameera M Aljohani, Shmeylan A. Al Harbi, S. Kojan, Majed Al Jeraisy, A. Deeb, J. Jose, Mohamed A. Hussein, Mohammed Al Muhaidib, M. Sadat, H. Al Anizi, Reggie Dael, A. Assiri, Mohammad A. Almazroa, A. Asiri, Z. Memish, S. Ghazal, Sarah H. Alfaraj, Fahad Bafaqeeh, Abdulrahman Al Harthy, Mohammed Al Sulaiman, A. Mady, Y. Mandourah, G. Almekhlafi, N. M. Sherbeeni, F. Elzein, R. Muhammed, Shatha Al Samirrai, Shatha Awad, Rylen Cabio Cabal, A. Malibary, Bander Al Onazi, M. Aljuhani, Melven Vince, Abdullah Almotairi, Mushira Al Enani, Alaa Alqurashi, Fatimah Alenezi, Nada M. Alkhani, Khalid A. Maghrabi, F. Al-Hameed, A. Alsaedi, A. Thaqafi, Ohoud Al Oraabi, Jalal Rifai, Pansy Elsamadisi, Medhat S. Hendy, S. Basher, Muhammed Abduldhaher, Wael Bajhamoum, I. Qushmaq, S. Shalhoub, Yusri Taha, Javed Memon, Shahinaz Bashir, I. Al-Dossary, Saleh Al Mekhloof, Bader Al-Muhainy, Shehab Suliman, M. Alshahrani, A. Al bshabshe, A. Kharaba, A. Al Jabri, Magdy F Farid, Alawi Alaidarous, Wael Alseraihi, H. Shahada, Jinish Shimi, S. Riaz, Bader Alharthi, Osama Yasin, Mohammad Khathlan, Robert A. Fowler, F. G. Hayden   +105 more
semanticscholar   +1 more source

Patients with Borderline Personality Disorder Not Participating in an RCT: Are They Different? [PDF]

, 2010
Background: Despite the notion that randomized controlled trials are regarded as the gold standard in psychotherapy research, questions about their generalizability have been raised. This paper focuses on the differences between participants and eligible
Buchheim, Peter, Bäuml, Josef, Döring, Stephan, Hörz, Susanne, Martius, Philipp, Rentrop, Michael   +5 more
core   +1 more source

The penumbra of randomized control trials

Perspectives in Clinical Research, 2013
Pre-occupation with randomized control trials as the basis of evidence-based medicine has increasingly shadowed other study designs over the last half a century. These include surveys, case-control studies, and case-cohort studies. They have the potential to overcome several ethical and cost constraints, but depend on the embedding of research in ...
openaire   +3 more sources

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Mingjing granule, a traditional Chinese medicine in the treatment of neovascular age-related macular degeneration: study protocol for a randomized controlled trial

Trials, 2021
Background Neovascular age-related macular degeneration (nAMD) is the most common cause of irreversible vision loss and blindness among the older people aged 50 and over.
Yamin Li, Lina Liang, Torkel Snellingen, Kai Xu, Yun Gao, Fengmei Zhang, Chengwei Guo, Tao Zuo, Fengming Liang, Xiaoping Yao, Xueyan Yang   +10 more
doaj   +1 more source