Results 101 to 110 of about 989,911 (307)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Clinical Performance of Posterior Inlay‐Retained and Wing‐Retained Monolithic Zirconia Resin‐Bonded Fixed Partial Dentures: Stage One Results of a Randomized Controlled Trial [PDF]
, 2020 Wolfgang Bömicke +7 more
openalex +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Acupotomy for Superior Cluneal Nerve Entrapment Syndrome: A Review of Randomized Controlled Trials
Journal of Acupuncture ResearchThis review aims to analyze the efficacy of acupotomy in treating superior cluneal nerve entrapment syndrome (SCNES) by summarizing the findings of randomized controlled trials (RCTs).
Hye Min Kim +5 more
doaj +1 more source
Annals of Surgery, 2006 During the 1960s and 1970s, the first randomized controlled trials in surgery were performed. Prior to this, surgical advances were largely made by physiologic experimentation in the laboratory and careful observation of series of patients. By relying on these types of studies, there was no doubt that appendectomy for acute appendicitis, surgery for ...
openaire +2 more sources
FEBS Open Bio, EarlyView.Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar +3 more
wiley +1 more source
Literature Review of Domestic Randomized Controlled Trials for Hominis Placenta Pharmacopuncture
Journal of Acupuncture ResearchThis study was conducted to analyze research trends, quality, and bias of pharmacopuncture studies, etc., on domestic randomized controlled trials (RCTs) using hominis placenta pharmacopuncture (HPP).
Hea Sun Chun
doaj +1 more source
Physician–Pharmacist Cooperation Program for Blood Pressure Control in Patients With Hypertension: A Randomized-Controlled Trial [PDF]
, 2010 Hiroko Tobari +6 more
openalex +1 more source