Results 111 to 120 of about 4,106,658 (410)
Molecular Oncology, EarlyView.Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker +14 more
wiley +1 more source
PLoS Medicine, 2005 Background Observational studies suggest that male circumcision may provide protection against HIV-1 infection. A randomized, controlled intervention trial was conducted in a general population of South Africa to test this hypothesis.
B. Auvert +5 more
semanticscholar +1 more source
BMC Infectious Diseases, 2022 Background Azithromycin is a broad-spectrum antibiotic that has moderate antimalarial activity and has been shown to reduce all-cause mortality when biannually administered to children under five in high mortality settings in sub-Saharan Africa.
Jessica Brogdon +15 more
doaj +1 more source
A randomized trial of an Asthma Internet Self-management Intervention (RAISIN): study protocol for a randomized controlled trial [PDF]
, 2014 <b>Background</b><p></p> The financial costs associated with asthma care continue to increase while care remains suboptimal. Promoting optimal self-management, including the use of asthma action plans, along with regular health ...
Agur, Karolina +7 more
core +1 more source
Tyranny of a "Randomized Controlled Trials"
Surgical Neurology International, 2012 “Evidence-based medicine” is a popular concept that simply means basing clinical decisions on best available scientific evidence. The idea appears very sensible and attractive – who would not want to be treated according to the best scientific evidence? As usual, complexity lurks just below the surface.
openaire +4 more sources
Molecular Oncology, EarlyView.In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen +13 more
wiley +1 more source
BMC Musculoskeletal Disorders, 2022 Background Osteoarthritis (OA) is the most common joint disease, and is most frequently seen in the knees. However, there is no effective therapy to relieve the progression of knee OA.
Guangfeng Ruan +16 more
doaj +1 more source
An exploration of women's experience of taking part in a randomized controlled trial of a diagnostic test during pregnancy: A qualitative study [PDF]
, 2019 Objective: To explore pregnant women's views of participation in a clinical research trial while pregnant. Design: Prospective nested qualitative cohort study embedded within a national, multi‐site randomized controlled trial of a diagnostic test for ...
Allesee L +4 more
core +1 more source
The penumbra of randomized control trials
Perspectives in Clinical Research, 2013 Pre-occupation with randomized control trials as the basis of evidence-based medicine has increasingly shadowed other study designs over the last half a century. These include surveys, case-control studies, and case-cohort studies. They have the potential to overcome several ethical and cost constraints, but depend on the embedding of research in ...
openaire +3 more sources
Molecular Oncology, EarlyView.The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina +17 more
wiley +1 more source