Lee Silverman voice treatment versus standard NHS speech and language therapy versus control in Parkinson's disease (PD COMM pilot):study protocol for a randomized controlled trial [PDF]
, 2014 Background: Parkinson’s disease is a common movement disorder affecting approximately 127,000 people in the UK, with an estimated two thirds having speech-related problems.
Brady, Marian C +13 more
core +4 more sources
Randomized double-blind placebo-controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial) [PDF]
, 2012 Introduction: Several observational studies suggest that statins modulate the pathophysiology of sepsis and may prevent its progression. The aim of this study was to determine if the acute administration of atorvastatin reduces sepsis progression in ...
Barnett, A. H. +11 more
core +3 more sources
Failure to Preserve β-Cell Function With Mycophenolate Mofetil and Daclizumab Combined Therapy in Patients With New- Onset Type 1 Diabetes [PDF]
, 2010 OBJECTIVE This trial tested whether mycophenolate mofetil (MMF) alone or with daclizumab (DZB) could arrest the loss of insulin-producing β-cells in subjects with new-onset type 1 diabetes.
Gottlieb, Peter A. +10 more
core +2 more sources
Journal of Orthopaedic Surgery and Research, 2021 Background Osteoarthritis of the knee is a common degenerative joint disorder in our ageing population. A combination of thermal therapy with a self-management exercise have shown a positive effect in the management of osteoarthritis of the knee.
Kevin Ki-Wai Ho +5 more
doaj +1 more source
Hypertension in Pregnancy, 2017 Objective: To determine whether oral labetalol is associated with a shorter time to blood pressure control compared to oral extended release nifedipine for management of persistent postpartum hypertension.
Kathryn J. Sharma +2 more
doaj +1 more source
Clinical and radiographic evaluation of a new stain-free tricalcium silicate cement in pulpotomies [PDF]
Brazilian Oral Research, 2020 The aim of this study was to evaluate and compare the clinical and radiographic success rates of pulpotomies in primary molars using a new stain-free tricalcium silicate cement (Bio-C Pulpo) versus a conventional white MTA (MTA Angelus) as a pulpotomy ...
Suéllen Priscilla Rodrigues de LIMA +5 more
doaj +1 more source
Randomized controlled trials in neurosurgery
Surgical Neurology International, 2022 Randomized controlled trials (RCTs) have become the standard method of evaluating new interventions (whether medical or surgical), and the best evidence used to inform the development of new practice guidelines. When we review the history of medical versus surgical trials, surgical RCTs usually face more challenges and difficulties when conducted ...
Takroni, Radwan +6 more
openaire +2 more sources
Effects of In-Bed Cycle Exercise in Patients With Acute Stroke: A Randomized Controlled Trial
Archives of Rehabilitation Research and Clinical Translation, 2020 Objective: To investigate the effects of in-bed cycle exercise in addition to usual care in patients with acute stroke, National Institutes of Health Stroke Scale (NIHSS) 7-42, regarding walking ability, functional outcomes, and inpatient care days ...
Klas Sandberg, MSc, RPT +3 more
doaj +1 more source
Lenalidomide in cancer cachexia: a randomized trial of an anticancer drug applied for anti‐cachexia
JCSM Rapid Communications, 2022 Background Cancer cachexia (CC) impacts quality of life, physical function, anticancer treatment response, and survival. Inflammation is a prominent pathomechanism of CC.
David Blum +6 more
doaj +1 more source
BMC Infectious Diseases, 2022 Background Azithromycin is a broad-spectrum antibiotic that has moderate antimalarial activity and has been shown to reduce all-cause mortality when biannually administered to children under five in high mortality settings in sub-Saharan Africa.
Jessica Brogdon +15 more
doaj +1 more source