Gynecology and Minimally Invasive Therapy, 2018 Objective: To evaluate the TRUCLEAR™ system (Smith and Nephew Inc., London, UK), a hysteroscopic system that morcellates and aspirates masses, in terms of the operating time, surgeon's convenience, and effect on patients compared with conventional ...
Akira Tsuchiya +5 more
doaj +1 more source
Adaptive Cohort Size Determination Method for Bayesian Optimal Interval Phase I/II Design to Shorten Clinical Trial Duration [PDF]
arXiv, 2023 Recently, the strategy for dose optimization in oncology has shifted to conduct Phase 2 randomized controlled trials with multiple doses. Optimal biologic dose selection from Phase 1 trial data to determine candidate doses for Phase 2 trials has been gaining attention.
arxiv
Improving end-of-life care in acute geriatric hospital wards using the Care Programme for the Last Days of Life : study protocol for a phase 3 cluster randomized controlled trial [PDF]
, 2015 Background: The Care Programme for the Last Days of Life has been developed to improve the quality of end-of-life care in acute geriatric hospital wards.
Cohen, Joachim +5 more
core +2 more sources
A double-blind randomized controlled trial of the effects of eicosapentaenoic acid supplementation on muscle inflammation and physical function in patients undergoing colorectal cancer resection [PDF]
, 2020 BackgroundResection of colorectal cancer (CRC) initiates inflammation, mediated at least partly by NFĸB (nuclear factor kappa-light-chain-enhancer of activated B-cells), leading to muscle catabolism and reduced physical performance. Eicosapentaenoic acid
Doleman, Brett +4 more
core +2 more sources
Comparing the Effects of Hot Shower and Intravenous Injection of Hyoscine on the Pain Intensity and Duration of Active Phase of Labour in Nulliparous Women [PDF]
Journal of Clinical and Diagnostic Research, 2018 Introduction: Parturition is a painful process and one of midwives’ duties is to reduce the pain during labour. Aim: To compare the effect of hot shower and intravenous injection of hyoscine on the pain severity and duration of active phase of labour ...
Safa Maddady Maddady +3 more
doaj +1 more source
Sensitivity analyses for effect modifiers not observed in the target population when generalizing treatment effects from a randomized controlled trial: Assumptions, models, effect scales, data scenarios, and implementation details [PDF]
PLOS ONE. 2018. 13(12): e0208795, 2020 Background: Randomized controlled trials are often used to inform policy and practice for broad populations. The average treatment effect (ATE) for a target population, however, may be different from the ATE observed in a trial if there are effect modifiers whose distribution in the target population is different that from that in the trial.
arxiv +1 more source
Randomized controlled trials in neurosurgery
Surgical Neurology International, 2022 Randomized controlled trials (RCTs) have become the standard method of evaluating new interventions (whether medical or surgical), and the best evidence used to inform the development of new practice guidelines. When we review the history of medical versus surgical trials, surgical RCTs usually face more challenges and difficulties when conducted ...
Takroni, Radwan +6 more
openaire +2 more sources
Web-Based Randomized Controlled Trial [PDF]
, 2017 Background: Patients often seek other patients’ experiences with the disease. The Internet provides a wide range of opportunities to share and learn about other people’s health and illness experiences via blogs or patient-initiated online discussion ...
Giesler, Jürgen M. +9 more
core +1 more source
Annals of Indian Academy of Neurology, 2023 Objectives: Benign paroxysmal positional vertigo (BPPV) is a condition in which a patient gets severe vertigo on moving his head from one position to another.
Neetu R Dhiman +4 more
doaj +1 more source
Platform Trials: the Impact of common Controls on Type One Error and Power [PDF]
arXiv, 2023 Platform trials offer a framework to study multiple interventions in a single trial with the opportunity of opening and closing arms. The use of a common control in platform trials can increase efficiency as compared to individual control arms or separate trials per treatment.
arxiv