Results 51 to 60 of about 4,120,157 (359)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Registry or randomization – must it be evidence or could it be coincidence?

Innovative Surgical Sciences
Over the years, clinical registries and randomized controlled trials gained acceptance. With increasing experience, it was possible to obtain knowledge of benefits and limitations in both designs.
Radulova Olga, Oehme Florian, Korn Sandra, Praetorius Christian, Distler Marius, Weitz Jürgen   +5 more
doaj   +1 more source

The importance of clinical trial protocols

HSJ
The International Committee of Medical Journal Editors (ICMJE) and the World Health Organization (WHO) define a clinical trial as any research that prospectively assigns participants or groups of human subjects to one or more interventions (medicines ...
Melissa Andreia de Moraes Silva
doaj   +1 more source

Promoting Independence in Dementia (PRIDE): A Feasibility Randomized Controlled Trial

Clinical Interventions in Aging, 2021
Emese Csipke,1 Aisha Shafayat,2 Kirsty Sprange,2 Lucy Bradshaw,2 Alan A Montgomery,2 Reuben Ogollah,2 Esme Moniz-Cook,3 Martin Orrell4 1Division of Psychiatry, University College London, London, UK; 2Nottingham Clinical Trials Unit, University of ...
Csipke E, Shafayat A, Sprange K, Bradshaw L, Montgomery AA, Ogollah R, Moniz-Cook E, Orrell M   +7 more
doaj  

Brief, Aerobic-surge Exercises for Effective Weight Loss: a Randomized, Controlled Trial [PDF]

, 2019
Background: Obesity is a growing disease and a consistently effective protocol is needed to reduce this epidemic. The purpose of this study was to determine if a frequent, brief (2-minute) high intensity aerobic exercise (≥75% max HR) was effective in ...
Curran, Sarah, Willis, F. Buck
core   +1 more source

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

Effect of high-definition transcranial direct current stimulation among late-subacute and chronic stroke survivors with fatigue: A randomized-controlled crossover trial protocol

MethodsX
Post-stroke fatigue (PSF) is a commonly overlooked symptom that impacts daily functioning and quality of life. It is caused by altered functional connectivity within the brain networks, which can potentially be influenced by neuromodulation.
Akhila Jagadish, Manikandan Natarajan, Divya Bharatkumar Adhia, Annapoorna Kuppuswamy, Vasudeva Guddattu, John M. Solomon   +5 more
doaj   +1 more source

A randomized controlled trial on the effect of focal thermal therapy at acupressure points treating osteoarthritis of the knee

Journal of Orthopaedic Surgery and Research, 2021
Background Osteoarthritis of the knee is a common degenerative joint disorder in our ageing population. A combination of thermal therapy with a self-management exercise have shown a positive effect in the management of osteoarthritis of the knee.
Kevin Ki-Wai Ho, Anthony Wai-Leung Kwok, Wai-Wang Chau, S. M. Xia, Y. L. Wang, Jack Chun-Yiu Cheng   +5 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Efficacy and safety of electroacupuncture for post stroke depression: study protocol for a randomized controlled trial

Trials, 2018
Background Poststroke depression is closely related to increased mortality in stroke patients. Compared with antidepressants, electroacupuncture (EA) treatment for poststroke depression (PSD) has relatively more stable effectiveness and can reduce side ...
Wa Cai, Wen Ma, Guan-Tao Wang, Wei-Dong Shen   +3 more
doaj   +1 more source