Results 51 to 60 of about 4,106,658 (410)

Sensitivity analyses for effect modifiers not observed in the target population when generalizing treatment effects from a randomized controlled trial: Assumptions, models, effect scales, data scenarios, and implementation details [PDF]

PLOS ONE. 2018. 13(12): e0208795, 2020
Background: Randomized controlled trials are often used to inform policy and practice for broad populations. The average treatment effect (ATE) for a target population, however, may be different from the ATE observed in a trial if there are effect modifiers whose distribution in the target population is different that from that in the trial.
arxiv   +1 more source

Symptom Monitoring With Patient-Reported Outcomes During Routine Cancer Treatment: A Randomized Controlled Trial.

Journal of Clinical Oncology, 2016
PURPOSE There is growing interest to enhance symptom monitoring during routine cancer care using patient-reported outcomes, but evidence of impact on clinical outcomes is limited.
E. Basch, A. Deal, M. Kris, H. Scher, C. Hudis, P. Sabbatini, L. Rogak, A. Bennett, A. Dueck, T. Atkinson, J. Chou, Dorothy Dulko, L. Sit, A. Barz, P. Novotny, M. Fruscione, J. Sloan, D. Schrag   +17 more
semanticscholar   +1 more source

Results from a randomized controlled trial testing StressProffen; an application‐based stress‐management intervention for cancer survivors

Cancer Medicine, 2020
In‐person cognitive‐behavioral stress‐management interventions are consistently associated with reduced cancer distress. However, face‐to‐face delivery is an access barrier for many patients, and there is a need to develop remote‐delivered interventions.
E. Børøsund, S. Ehlers, C. Varsi, M. Clark, M. Andrykowski, M. Cvancarova, Lise Solberg Nes   +6 more
semanticscholar   +1 more source

Conditional average treatment effect estimation with marginally constrained models [PDF]

, 2022
Treatment effect estimates are often available from randomized controlled trials as a single average treatment effect for a certain patient population. Estimates of the conditional average treatment effect (CATE) are more useful for individualized treatment decision making, but randomized trials are often too small to estimate the CATE.
arxiv   +1 more source

Randomized controlled trials in neurosurgery

Surgical Neurology International, 2022
Randomized controlled trials (RCTs) have become the standard method of evaluating new interventions (whether medical or surgical), and the best evidence used to inform the development of new practice guidelines. When we review the history of medical versus surgical trials, surgical RCTs usually face more challenges and difficulties when conducted ...
Takroni, Radwan, Sharma, Sunjay, Reddy, Kesava, Zagzoog, Nirmeen, Aljoghaiman, Majid, Alotaibi, Mazen, Farrokhyar, Forough   +6 more
openaire   +2 more sources

A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group.

New England Journal of Medicine, 1999
BACKGROUND To determine whether a restrictive strategy of red-cell transfusion and a liberal strategy produced equivalent results in critically ill patients, we compared the rates of death from all causes at 30 days and the severity of organ dysfunction.
Paul C. Hébert, G. Wells, M. Blajchman, John C. Marshall, C. Martin, G. Pagliarello, M. Tweeddale, I. Schweitzer, E. Yetisir   +8 more
semanticscholar   +1 more source

Oral labetalol compared to oral nifedipine for postpartum hypertension: A randomized controlled trial

Hypertension in Pregnancy, 2017
Objective: To determine whether oral labetalol is associated with a shorter time to blood pressure control compared to oral extended release nifedipine for management of persistent postpartum hypertension.
Kathryn J. Sharma, Naomi Greene, Sarah J. Kilpatrick   +2 more
doaj   +1 more source

Platform Trials: the Impact of common Controls on Type One Error and Power [PDF]

arXiv, 2023
Platform trials offer a framework to study multiple interventions in a single trial with the opportunity of opening and closing arms. The use of a common control in platform trials can increase efficiency as compared to individual control arms or separate trials per treatment.
arxiv  

Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial.

Gastroenterology, 2015
BACKGROUND & AIMS Ulcerative colitis (UC) is difficult to treat, and standard therapy does not always induce remission. Fecal microbiota transplantation (FMT) is an alternative approach that induced remission in small series of patients with active UC ...
P. Moayyedi, M. Surette, P. Kim, J. Libertucci, M. Wolfe, Catherine Onischi, D. Armstrong, J. Marshall, Z. Kassam, W. Reinisch, Christine H. Lee   +10 more
semanticscholar   +1 more source

A Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity.

New England Journal of Medicine, 2020
BACKGROUND Obesity is a chronic disease with limited treatment options in pediatric patients. Liraglutide may be useful for weight management in adolescents with obesity.
A. Kelly, Pernille Auerbach, M. Barrientos-Pérez, I. Gies, P. M. Hale, C. Marcus, L. Mastrandrea, Nandana Prabhu, S. Arslanian   +8 more
semanticscholar   +1 more source