Results 51 to 60 of about 2,170,785 (365)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Noninvasive vagus nerve stimulation as acute therapy for migraine. The randomized PRESTO study [PDF]

, 2018
Objective: To evaluate the efficacy, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS; gammaCore; electroCore, LLC, Basking Ridge, NJ) for the acute treatment of migraine in a multicenter, double-blind, randomized, sham-controlled ...
Ambrosini, Anna, Barbanti, Piero, De Tommaso, Marina, Dorlas, Stefanie, Geppetti, Pierangelo, Grazzi, Licia, Liebler, Eric, Martelletti, Paolo, Negro, Andrea, Pierangeli, Giulia, Rainero, Innocenzo, Sarchielli, Paola, Tassorelli, Cristina   +12 more
core   +2 more sources

Comparison of Methods that Combine Multiple Randomized Trials to Estimate Heterogeneous Treatment Effects [PDF]

arXiv, 2023
Individualized treatment decisions can improve health outcomes, but using data to make these decisions in a reliable, precise, and generalizable way is challenging with a single dataset. Leveraging multiple randomized controlled trials allows for the combination of datasets with unconfounded treatment assignment to better estimate heterogeneous ...
arxiv  

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Promoting Independence in Dementia (PRIDE): A Feasibility Randomized Controlled Trial

Clinical Interventions in Aging, 2021
Emese Csipke,1 Aisha Shafayat,2 Kirsty Sprange,2 Lucy Bradshaw,2 Alan A Montgomery,2 Reuben Ogollah,2 Esme Moniz-Cook,3 Martin Orrell4 1Division of Psychiatry, University College London, London, UK; 2Nottingham Clinical Trials Unit, University of ...
Csipke E, Shafayat A, Sprange K, Bradshaw L, Montgomery AA, Ogollah R, Moniz-Cook E, Orrell M   +7 more
doaj  

Uso Delle Medicine Complementari in Nefrologia: Una Revisione di Studi Randomizzati Controllati (RTC)

Giornale di Clinica Nefrologia e Dialisi, 2017
non disponibile (nursing)
Lisa Bovo, Francesco Burrai, Fabiola Canossa   +2 more
doaj   +1 more source

Compliance of published randomized controlled trials on the effect of physical activity on primary dysmenorrhea with the consortium's integrated report on clinical trials statement: A critical appraisal of the literature

Iranian Journal of Nursing and Midwifery Research, 2020
Background: Randomized Controlled Trials (RCTs) are reliable methods for the evaluation of treatment effectiveness, which should be rigorous and must report with clarity.
Elham Manouchehri, Somayeh Alirezaei, Robab Latifnejad Roudsari   +2 more
doaj   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Home-based reach-to-grasp training for people after stroke: study protocol for a feasibility randomized controlled trial [PDF]

, 2013
BackgroundThis feasibility study is intended to assess the acceptability of home-based task-specific reach-to-grasp (RTG) training for people with stroke, and to gather data to inform recruitment, retention, and sample size for a definitive randomized ...
Cunningham, Paul, Heron, Emma, Jowett, Sue, Rogers, Chris, Sackley, Cath, Turton, Ailie J., van Vliet, Paulette, van Wijck, Frederike, Wheatley, Keith, Wolf, Steven L.   +9 more
core   +1 more source

Efficacy and safety of electroacupuncture for post stroke depression: study protocol for a randomized controlled trial

Trials, 2018
Background Poststroke depression is closely related to increased mortality in stroke patients. Compared with antidepressants, electroacupuncture (EA) treatment for poststroke depression (PSD) has relatively more stable effectiveness and can reduce side ...
Wa Cai, Wen Ma, Guan-Tao Wang, Wei-Dong Shen   +3 more
doaj   +1 more source