Results 51 to 60 of about 1,884,582 (342)

Efficacy and safety of electroacupuncture for post stroke depression: study protocol for a randomized controlled trial

Trials, 2018
Background Poststroke depression is closely related to increased mortality in stroke patients. Compared with antidepressants, electroacupuncture (EA) treatment for poststroke depression (PSD) has relatively more stable effectiveness and can reduce side ...
Wa Cai, Wen Ma, Guan-Tao Wang, Wei-Dong Shen   +3 more
doaj   +1 more source

The Effects of Cognitive Behavioral Therapy on Depression and Anxiety among Patients with Thalassemia: a Randomized Controlled Trial [PDF]

Journal of Caring Sciences, 2018
Introduction: Thalassemia is a chronic hereditary anemia which can be associated with different psychological, emotional, and behavioral problems such as depression and anxiety.
Fateme Mohamadian, Maryam Bagheri, Maryam Sadat Hashemi, Hossein Komeili Sani   +3 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Occupational therapy predischarge home visits for patients with a stroke (HOVIS): results of a feasibility randomized controlled trial [PDF]

, 2013
Objective: To assess the feasibility of conducting a randomized controlled trial of occupational therapy predischarge home visits for people after stroke. Design: Randomized controlled trial and cohort study.
Drummond, A.E.R., Edwards, Claire, Fellows, K., Lincoln, Nadina, Sampson, Christopher James, Sprigg, Nikola, Whitehead, P.   +6 more
core  

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Likelihood reweighting methods to reduce potential bias in noninferiority trials which rely on historical data to make inference

, 2013
It is generally believed that bias is minimized in well-controlled randomized clinical trials. However, bias can arise in active controlled noninferiority trials because the inference relies on a previously estimated effect size obtained from a ...
Chu, Jianxiong, Nie, Lei, Rubin, Daniel, Zhang, Zhiwei   +3 more
core   +1 more source

Home-based reach-to-grasp training for people after stroke: study protocol for a feasibility randomized controlled trial [PDF]

, 2013
BackgroundThis feasibility study is intended to assess the acceptability of home-based task-specific reach-to-grasp (RTG) training for people with stroke, and to gather data to inform recruitment, retention, and sample size for a definitive randomized ...
Cunningham, Paul, Heron, Emma, Jowett, Sue, Rogers, Chris, Sackley, Cath, Turton, Ailie J., van Vliet, Paulette, van Wijck, Frederike, Wheatley, Keith, Wolf, Steven L.   +9 more
core   +2 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

A cluster randomized controlled trial of the effectiveness and cost-effectiveness of Intermediate Care Clinics for Diabetes (ICCD) : study protocol for a randomized controlled trial [PDF]

, 2012
Background World-wide healthcare systems are faced with an epidemic of type 2 diabetes. In the United Kingdom, clinical care is primarily provided by general practitioners (GPs) rather than hospital specialists.
A Donner, A Gray, A Nocon, A Nocon, A Strauss, AG Mainous 3rd, Ainsley Hardy, Ala Szczepura, Andrew Wilson, Bazeley P, C Bradley, C Millett, C Millett, C Millett, CM Renders, Darrin Baines, EC Goyder, FE Van der Does, G Richardson, GW Welch, J Hippisley-Cox, JH Ahroni, Joseph Paul O’Hare, K Khunti, Kamlesh Khunti, KK Ray, Lambeth Diabetes Intermediate Care Team, M Campbell, MC Gulliford, MC Gulliford, Melanie Davies, MF Drummond, MM Collins, N Graves, N Papanas, Natalie Armstrong, Neil Raymond, NF Olivarius, Nigel Stallard, P Craig, P Gaede, Ponnusamy Saravanan, PW Vermunt, R Baker, R Rabin, Richard Baker, Richard Crossman, RR Holman, RR Holman, S Bellary, SJ Griffin, Sudhesh Kumar, The Euroqol Group, The NHS Confederation   +53 more
core   +3 more sources