Results 61 to 70 of about 2,170,785 (365)

Sample size calculations for n-of-1 trials [PDF]

arXiv, 2021
N-of-1 trials, single participant trials in which multiple treatments are sequentially randomized over the study period, can give direct estimates of individual-specific treatment effects. Combining n-of-1 trials gives extra information for estimating the population average treatment effect compared with randomized controlled trials and increases ...
arxiv  

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Occupational therapy predischarge home visits for patients with a stroke (HOVIS): results of a feasibility randomized controlled trial [PDF]

, 2013
Objective: To assess the feasibility of conducting a randomized controlled trial of occupational therapy predischarge home visits for people after stroke. Design: Randomized controlled trial and cohort study.
Drummond, A.E.R., Edwards, Claire, Fellows, K., Lincoln, Nadina, Sampson, Christopher James, Sprigg, Nikola, Whitehead, P.   +6 more
core  

The importance of clinical trial protocols

HSJ
The International Committee of Medical Journal Editors (ICMJE) and the World Health Organization (WHO) define a clinical trial as any research that prospectively assigns participants or groups of human subjects to one or more interventions (medicines ...
Melissa Andreia de Moraes Silva
doaj   +1 more source

Statistical and methodological considerations for reporting RCTs in medical literature [PDF]

Korean Journal of Anesthesiology, 2015
Randomized controlled trials (RCTs) are known to provide the most reliable evidence on intervention. However, RCTs are often conducted and reported incompletely and inadequately, making readers and reviewers unable to judge the validity and reliability ...
Sangseok Lee, Hyun Kang
doaj   +1 more source

Funding of Studies Supporting IA Guideline Recommendations in Cardiovascular Medicine—A Systematic Review

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Each guideline recommendation from the American Heart Association and the American College of Cardiology includes an indication of the level of supporting evidence and the associated strength of recommendation with “IA” recommendations representing those
Emily P. Zeitler, Alessio Gasperetti, Shayne E. Dodge, Lauren B. Cooper, Aaron V. Kaplan   +4 more
doaj   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Low Dose Celecoxib Combined with Clozapine for Treatment of Schizophrenia: A Double Blind Randomized Clinical Trial [PDF]

International Journal of Travel Medicine and Global Health, 2015
Introduction: Higher levels of pro-inflammatory cytokines in schizophrenia have suggested that dysfunctions of the immune system may play a role in this disabling condition.
Roya Samadi, Ali Akhondpour Manteghi, Mehri Baghban Haghighi, Amin Azhari, Shervin Assari   +4 more
doaj   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Electroacupuncture treatment for sarcopenia: study protocol for a randomized controlled trial

BMC Complementary Medicine and Therapies
Introduction Sarcopenia is a disease primarily characterized by age-related loss of skeletal muscle mass, muscle strength, and/or decline in physical performance.
Hao Li, Li Zhou, Xin Zhang, Qian Wen, Li Tian, Han Yang, Xirong Chen, Jinghan Yuan, Ning Li, Bingmei Zhu, Lin Zhang, Lingyun Lu   +11 more
doaj   +1 more source