Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis: systematic review and meta-regression [PDF]
Multiple Sclerosis Journal, 19(12):1580-1586, 2013, 2013 Background: Recent studies have shown a decrease in annualised relapse rates (ARRs) in placebo groups of randomised controlled trials (RCTs) in relapsing multiple sclerosis (RMS). Methods: We conducted a systematic literature search of RCTs in RMS.
arxiv +1 more source
A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis.
New England Journal of MedicineBACKGROUND Nonalcoholic steatohepatitis (NASH) is a progressive liver disease with no approved treatment. Resmetirom is an oral, liver-directed, thyroid hormone receptor beta-selective agonist in development for the treatment of NASH with liver fibrosis.
Stephen A. Harrison +28 more
semanticscholar +1 more source
Trials, 2021 Background Neovascular age-related macular degeneration (nAMD) is the most common cause of irreversible vision loss and blindness among the older people aged 50 and over.
Yamin Li +10 more
doaj +1 more source
A matching design for augmenting a randomized clinical trial with external control [PDF]
arXiv, 2022 The use of information from real world to assess the effectiveness of medical products is becoming increasingly popular and more acceptable by regulatory agencies. According to a strategic real-world evidence framework published by U.S. Food and Drug Administration, a hybrid randomized controlled trial that augments internal control arm with real-world
arxiv
Frequency of Reporting and the Quality of Randomized Controlled Trials Published in the Nigerian Journal of Ophthalmology [PDF]
, 2010 Aim: To determine the frequency of reporting and the methodological quality of randomized controlled trials in the Nigerian Journal of Ophthalmology (NJO) from 1993 – 2001.Materials and methods: Back issues of NJO published from 1993 to 2001 were ...
Alhassan, M.B, Ejere, H
core +2 more sources
Population Ecology, EarlyView.In the process of captive breeding and reintroduction of endangered animal species, it is crucial to minimize familial bias in reproductive success during the reintroduction phase to preserve genetic diversity. In this study, we attempted to identify the familial lineage of individuals of the endangered bagrid fish Tachysurus ichikawai born at the ...
Hinano Mizuno +5 more
wiley +1 more source
The importance of clinical trial protocols
HSJThe International Committee of Medical Journal Editors (ICMJE) and the World Health Organization (WHO) define a clinical trial as any research that prospectively assigns participants or groups of human subjects to one or more interventions (medicines ...
Melissa Andreia de Moraes Silva
doaj +1 more source
Systematic Review and the External Validity of Randomized Controlled Trials in Lupus Nephritis
Kidney International Reports, 2018 Randomized controlled trials (RCTs) are considered the gold standard for assessing treatment efficacy. However, sampling bias can affect the generalization of results to routine clinical practice.
Angela Pakozdi +4 more
doaj +1 more source
A Randomized Double-blind Comparative Study of the Efficacy of Eradication Therapy and Motilitone for Functional Dyspepsia [PDF]
The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2019 Background/Aims Helicobacter pylori (H. pylori) infection is one of the etiologies of functional dyspepsia (FD). The aim of this study was to compare the efficacy of H. pylori eradication therapy and motilitone monotherapy in patients with FD.
Jae Yong Park +6 more
doaj +1 more source
Specific-class Skin Side-effects of Drugs Might Compromise Blinding in Randomized Controlled Trials
Acta Dermato-Venereologica, 2023 is missing (Short communication)
Giao Do-Pham +4 more
doaj +1 more source