Results 71 to 80 of about 1,926,046 (358)

Electroacupuncture treatment for sarcopenia: study protocol for a randomized controlled trial

BMC Complementary Medicine and Therapies
Introduction Sarcopenia is a disease primarily characterized by age-related loss of skeletal muscle mass, muscle strength, and/or decline in physical performance.
Hao Li, Li Zhou, Xin Zhang, Qian Wen, Li Tian, Han Yang, Xirong Chen, Jinghan Yuan, Ning Li, Bingmei Zhu, Lin Zhang, Lingyun Lu   +11 more
doaj   +1 more source

Systematic Review and the External Validity of Randomized Controlled Trials in Lupus Nephritis

Kidney International Reports, 2018
Randomized controlled trials (RCTs) are considered the gold standard for assessing treatment efficacy. However, sampling bias can affect the generalization of results to routine clinical practice.
Angela Pakozdi, Ravindra Rajakariar, Debasish Pyne, Andrea Cove-Smith, Muhammad Magdi Yaqoob   +4 more
doaj   +1 more source

Analysis of Randomized Controlled Trials [PDF]

Epidemiologic Reviews, 2002
Although the sophistication and flexibility of the statistical technology available to the data analyst have increased, some durable, simple principles remain valid. Hypothesis-driven analyses, which were anticipated and specified in the protocol, must still be kept separate and privileged relative to the important, but risky data mining made possible ...
Peter Peduzzi, William Henderson, Pamela M. Hartigan, Philip W. Lavori, Philip W. Lavori   +4 more
openaire   +2 more sources

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

DO IT Trial: vitamin D Outcomes and Interventions in Toddlers - a TARGet Kids! randomized controlled trial. [PDF]

, 2014
BackgroundVitamin D levels are alarmingly low (<75 nmol/L) in 65-70% of North American children older than 1 year. An increased risk of viral upper respiratory tract infections (URTI), asthma-related hospitalizations and use of anti-inflammatory ...
Birken, Catherine S, Borkhoff, Cornelia M, Hoch, Jeffrey S, Loeb, Mark B, Macarthur, Colin, Maguire, Jonathon L, Mamdani, Muhammad, Mazzulli, Tony, Parkin, Patricia C, TARGet Kids! Collaboration, Thorpe, Kevin   +10 more
core   +3 more sources

The Effects of Vitamin D on Sexual Function and Hormones in Women with Multiple Sclerosis [PDF]

Journal of Client-centered Nursing Care
Background: Sexual dysfunction (SD) is the most common and challenging complication among women with multiple sclerosis (MS). Despite investigations into the impact of taking vitamin D on sexual function (SF), findings have not definitively recommended ...
Simin Zarabadi-pour, Mohammad Eghbali, Leila Amini, Seyed Massood Nabavi, Hamid Haghani, Homa Sadeghi Avval Shahr   +5 more
doaj  

The Effects of Cognitive Behavioral Therapy on Depression and Anxiety among Patients with Thalassemia: a Randomized Controlled Trial [PDF]

Journal of Caring Sciences, 2018
Introduction: Thalassemia is a chronic hereditary anemia which can be associated with different psychological, emotional, and behavioral problems such as depression and anxiety.
Fateme Mohamadian, Maryam Bagheri, Maryam Sadat Hashemi, Hossein Komeili Sani   +3 more
doaj   +1 more source

Tyranny of a "Randomized Controlled Trials"

Surgical Neurology International, 2012
“Evidence-based medicine” is a popular concept that simply means basing clinical decisions on best available scientific evidence. The idea appears very sensible and attractive – who would not want to be treated according to the best scientific evidence? As usual, complexity lurks just below the surface.
openaire   +4 more sources

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Prospective, double-blind, randomized controlled trial of electrophysiologically guided femoral nerve block in total knee arthroplasty

Therapeutics and Clinical Risk Management, 2013
Yoon Seok Youm,1 Sung Do Cho,1 Chang Ho Hwang21Department of Orthopedic Surgery, 2Department of Physical Medicine and Rehabilitation, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of KoreaBackground: The purpose of ...
Youm YS, Cho SD, Hwang CH
doaj