Results 71 to 80 of about 2,170,785 (365)

Effect of electroacupuncture on discomfort during gastroscopy: a study protocol for a randomized controlled trial

Trials, 2022
Background Gastroscopy procedures are frequently performed under general sedation to minimize discomfort. Patients who refuse a sedative injection may experience more discomfort and adverse reactions such as pain and nausea.
Binyu Yu, Philippa Jemma Hazlewood, Xuan Yin, Shanshan Li, Hongyu Yue, Kun Xu, Shifen Xu, Yiqun Mi   +7 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

A Randomized Controlled Trial of Sertraline in Young Children With Autism Spectrum Disorder. [PDF]

, 2019
Objective: Selective serotonin reuptake inhibitors like sertraline have been shown in observational studies and anecdotal reports to improve language development in young children with fragile X syndrome (FXS).
Al Olaby, Reem R, Biag, Hazel Maridith B, Chen, Yanjun, Choudhary, Nimrah S, Dwyer, Patrick S, Hagerman, Randi J, Nguyen, Danh V, Potter, Laura A, Rajaratnam, Akash, Rivera, Susan M, Salcedo-Arellano, Maria J, Schneider, Andrea, Scholze, Danielle A, Tassone, Flora   +13 more
core  

Lee Silverman voice treatment versus standard NHS speech and language therapy versus control in Parkinson's disease (PD COMM pilot):study protocol for a randomized controlled trial [PDF]

, 2014
Background: Parkinson’s disease is a common movement disorder affecting approximately 127,000 people in the UK, with an estimated two thirds having speech-related problems.
Brady, Marian C, Clarke, Carl, Dowling, Francis, Ives, Natalie, Jowett, Sue, Kelly, Debbie, Patel, Ramilla, Patel, Smitaa, Rick, Caroline, Roberts, Helen, Sackley, Catherine M, Sands, Gina, Smith, Christina H, Wheatley, Keith   +13 more
core   +4 more sources

Sample size for a non-inferiority clinical trial with time-to-event data in the presence of competing risks [PDF]

Journal of Biopharmaceutical Statistics, 2018, 28:797-807, 2018
The analysis and planning methods for competing risks model have been described in the literatures in recent decades, and non-inferiority clinical trials are helpful in current pharmaceutical practice. Analytical methods for non-inferiority clinical trials in the presence of competing risks were investigated by Parpia et al., who indicated that the ...
arxiv   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial : study protocol for a randomized controlled trial [PDF]

, 2012
Acute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure.
A Mercat, AM Cheung, C Brun-Buisson, C Rossi, Cecilia M O’Kane, Christine McNally, Daniel F McAuley, DJ Kor, Excellence NIfHaC, F Gao Smith, Gavin D Perkins, GD Rubenfeld, GR Bernard, Grainne Crealey, Irish Critical Care Trials Group, John G Laffey, KF Schulz, LA Curtis, Lynn Murphy, M Shyamsundar, MA Matthay, Mark Cross, Michael Stevenson, MS Herridge, RG Brower, S Harvey, SE Erickson, T Craig, The ARDS Network investigators, The EuroQol Group, TR Craig, TW Felton   +31 more
core   +1 more source

Simvastatin treatment does not affect serum Vitamin D concentrations in patients with dyslipidemia: A randomized double-blind placebo-controlled cross-over trial

International Journal of Preventive Medicine, 2016
Background: Hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) are antihyperlipidemic drugs with an established efficacy in stabilizing atherosclerotic plaques and preventing atherogenesis and reducing cardiovascular events.
Mohsen Mazidi, Haleh Rokni, Amir Hossein Sahebkar, Akram Mohammadi, Majid Ghayour-Mobarhan, Gordon A Ferns   +5 more
doaj   +1 more source

Annual Zoledronic Acid for the Treatment of Osteoporosis: A Randomized Controlled Trial

Journal of Orthopedics, Traumatology and Rehabilitation, 2023
Context: Osteoporosis remains a significant public health problem in many parts of the world, including India. The efficacy of oral bisphosphonates is lower because of poor compliance.
Asif Hussain, Sushil Kumar Saini, Jaydeep Patel, Chandra Prakash Pal, Hemant Singh Chahar, Rohit Yadav   +5 more
doaj   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source