Results 81 to 90 of about 2,170,785 (365)

Investigation of the Effect of Multimedia Education on Anxiety Before and After Surgery in Patients Undergoing Coronary Artery Bypass Graft Surgery

مراقبت پرستاری و مامایی ابن سینا, 2018
Introduction: Anxiety is one of the prevalent events before and after surgery which occurs in patients due to the waiting time for heart surgery, hospitalization, fear of death, and in general the fear of unknowns. This study was conducted to investigate
Kosar Fahimi, Ali Abbasi, Mahdi Zahedi, Farzaneh Amanpour, Maryam Gilani, Hossein Ebrahimi   +5 more
doaj  

Analysis of Randomized Controlled Trials [PDF]

Epidemiologic Reviews, 2002
Although the sophistication and flexibility of the statistical technology available to the data analyst have increased, some durable, simple principles remain valid. Hypothesis-driven analyses, which were anticipated and specified in the protocol, must still be kept separate and privileged relative to the important, but risky data mining made possible ...
Peter Peduzzi, William Henderson, Pamela M. Hartigan, Philip W. Lavori, Philip W. Lavori   +4 more
openaire   +2 more sources

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

What is the best way to manage benign paroxysmal positional vertigo? [PDF]

, 2003
A simple repositioning maneuver, such as the Epley maneuver, performed by an experienced clinician, can provide symptom relief from benign paroxysmal positional vertigo (BPPV) lasting at least 1 month (strength of recommendation [SOR]: A, systematic ...
Russell, Roger G., Strickland, Carmen
core  

A cluster randomized controlled trial of the effectiveness and cost-effectiveness of Intermediate Care Clinics for Diabetes (ICCD) : study protocol for a randomized controlled trial [PDF]

, 2012
Background World-wide healthcare systems are faced with an epidemic of type 2 diabetes. In the United Kingdom, clinical care is primarily provided by general practitioners (GPs) rather than hospital specialists.
A Donner, A Gray, A Nocon, A Nocon, A Strauss, AG Mainous 3rd, Ainsley Hardy, Ala Szczepura, Andrew Wilson, Bazeley P, C Bradley, C Millett, C Millett, C Millett, CM Renders, Darrin Baines, EC Goyder, FE Van der Does, G Richardson, GW Welch, J Hippisley-Cox, JH Ahroni, Joseph Paul O’Hare, K Khunti, Kamlesh Khunti, KK Ray, Lambeth Diabetes Intermediate Care Team, M Campbell, MC Gulliford, MC Gulliford, Melanie Davies, MF Drummond, MM Collins, N Graves, N Papanas, Natalie Armstrong, Neil Raymond, NF Olivarius, Nigel Stallard, P Craig, P Gaede, Ponnusamy Saravanan, PW Vermunt, R Baker, R Rabin, Richard Baker, Richard Crossman, RR Holman, RR Holman, S Bellary, SJ Griffin, Sudhesh Kumar, The Euroqol Group, The NHS Confederation   +53 more
core   +3 more sources

The Effects of Vitamin D on Sexual Function and Hormones in Women with Multiple Sclerosis [PDF]

Journal of Client-centered Nursing Care
Background: Sexual dysfunction (SD) is the most common and challenging complication among women with multiple sclerosis (MS). Despite investigations into the impact of taking vitamin D on sexual function (SF), findings have not definitively recommended ...
Simin Zarabadi-pour, Mohammad Eghbali, Leila Amini, Seyed Massood Nabavi, Hamid Haghani, Homa Sadeghi Avval Shahr   +5 more
doaj  

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Systematic Review and the External Validity of Randomized Controlled Trials in Lupus Nephritis

Kidney International Reports, 2018
Randomized controlled trials (RCTs) are considered the gold standard for assessing treatment efficacy. However, sampling bias can affect the generalization of results to routine clinical practice.
Angela Pakozdi, Ravindra Rajakariar, Debasish Pyne, Andrea Cove-Smith, Muhammad Magdi Yaqoob   +4 more
doaj   +1 more source

Tyranny of a "Randomized Controlled Trials"

Surgical Neurology International, 2012
“Evidence-based medicine” is a popular concept that simply means basing clinical decisions on best available scientific evidence. The idea appears very sensible and attractive – who would not want to be treated according to the best scientific evidence? As usual, complexity lurks just below the surface.
openaire   +4 more sources

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source