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Randomized Controlled Trials [PDF]

Chest, 2020
Randomized controlled trials (RCTs) are considered the highest level of evidence to establish causal associations in clinical research. There are many RCT designs and features that can be selected to address a research hypothesis. Designs of RCTs have become increasingly diverse as new methods have been proposed to evaluate increasingly complex ...
Emily C, Zabor, Alexander M, Kaizer, Brian P, Hobbs   +2 more
semanticscholar   +5 more sources

Randomized controlled trials [PDF]

Phlebology: The Journal of Venous Disease, 2011
Proponents of evidence-based medicine would acknowledge that several sources of evidence inform clinical decision making. Hierarchies of evidence have, however, been developed to help describe the quality of evidence that may be found to answer our clinical questions. According to this classification, the randomized clinical trial is the most effective
  +9 more sources

PRECAF Randomized Controlled Trial [PDF]

Circulation: Arrhythmia and Electrophysiology, 2021
Background: We have previously shown that the presence of dual muscular coronary sinus (CS) to left atrial (LA) connections, coupled with rate-dependent unidirectional block in one limb, is associated with atrial fibrillation (AF) induction. This study sought to examine whether ablation of distal CS to LA connections at a first
Ling Kuo, David S. Frankel, Aung Lin, Jeffrey Arkles, Matthew Hyman, Pasquale Santangeli, Francis E. Marchlinski, Saman Nazarian   +7 more
openaire   +2 more sources

Understanding noninferiority trials [PDF]

Korean Journal of Pediatrics, 2012
Noninferiority trials test whether a new experimental treatment is not unacceptably less efficacious than an active control treatment already in use.
Seokyung Hahn
doaj   +1 more source

The Effectiveness of Budesonide in the Treatment of Asthma Attacks in Children: A Systematic Review and Meta-Analysis [PDF]

Preventive Care in Nursing and Midwifery Journal, 2023
Background: Severe and moderate asthma attacks are among the major causes of children’s visits to emergency departments. Objectives: The present systematic review is conducted to assess the effectiveness of inhaled budesonide on hospitalization and ...
Akefeh Ahmadi Afshar, Maryam Rahmati, Azam Maleki, Kourosh Kamali   +3 more
doaj   +1 more source

The Randomized Controlled Trial [PDF]

Nephron Clinical Practice, 2009
Until recently, high-quality randomized controlled trials (RCTs) have rarely been performed in nephrology, because of several difficulties in conducting an RCT. The purpose of this article is to describe several issues related to the design and to the quality of RCTs in their conduct, analysis, interpretation, and reporting of the results.
Stel, Vianda S., Zoccali, Carmine, Dekker, Friedo W., Jager, Kitty J.   +3 more
openaire   +2 more sources

Interpreting Randomized Controlled Trials

Cancers, 2023
This article describes rationales and limitations for making inferences based on data from randomized controlled trials (RCTs). We argue that obtaining a representative random sample from a patient population is impossible for a clinical trial because patients are accrued sequentially over time and thus comprise a convenience sample, subject only to ...
Pavlos Msaouel, Juhee Lee, Peter F Thall
openaire   +2 more sources

Mapping multicenter randomized controlled trials in anesthesiology: a scoping review

Systematic Reviews, 2021
Background Evidence suggests that there are substantial inconsistencies in the practice of anesthesia. There has not yet been a comprehensive summary of the anesthesia literature that can guide future knowledge translation interventions to move evidence ...
Sylvain Boet, Joseph K. Burns, Olivia Cheng-Boivin, Hira Khan, Kendra Derry, Deric Diep, Abdul Hadi Djokhdem, Sung Wook Um, Johnny W. Huang, Danica Paré, Mimi Deng, Liza Begunova, Linda Yi Ning Fei, Maryam Bezzahou, Pium Sonali Andrahennadi, Elysia Grose, Ruth G Abebe, Fadi Mansour, Zoé Talbot, Pierre-Marc Dion, Manvinder Kaur, Cole Etherington   +21 more
doaj   +1 more source

A bayesian meta-analysis of multiple treatment comparisons of systemic regimens for advanced pancreatic cancer [PDF]

, 2014
© 2014 Chan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
AJ Sutton, C Louvet, D Cunningham, D Li, DC Hoglin, DD Von Hoff, DG Altman, Doug Coyle, E Poplin, F Di Costanzo, G Colucci, G Colucci, H Ueno, HA Burris 3rd, Henry Lam, JD Berlin, Jonathan R. Brody, JP Higgins, Kelly Lien, Kelvin Chan, Keya Shah, M Ozaka, MH Kulke, MJ Moore, MK Parmar, PA Philip, PF Peddi, R Herrmann, R Warsame, S Boeck, T Conroy, T Li, V Heinemann, W Scheithauer, X Wang, Y Nakai, Yoo-Joung Ko   +36 more
core   +8 more sources

Partnership for Research on Ebola VACcination (PREVAC): protocol of a randomized, double-blind, placebo-controlled phase 2 clinical trial evaluating three vaccine strategies against Ebola in healthy volunteers in four West African countries

Trials, 2021
Introduction The Ebola virus disease (EVD) outbreak in 2014–2016 in West Africa was the largest on record and provided an opportunity for large clinical trials and accelerated efforts to develop an effective and safe preventative vaccine.
Moses Badio, Edouard Lhomme, Mark Kieh, Abdoul Habib Beavogui, Stephen B. Kennedy, Seydou Doumbia, Bailah Leigh, Samba O. Sow, Alpha Diallo, Daniela Fusco, Matthew Kirchoff, Monique Termote, Renaud Vatrinet, Deborah Wentworth, Helène Esperou, H. Clifford Lane, Jerome Pierson, Deborah Watson-Jones, Céline Roy, Eric D’Ortenzio, Brian Greenwood, Genevieve Chêne, Laura Richert, James D. Neaton, Yazdan Yazdanpanah, the PREVAC study team   +25 more
doaj   +1 more source