Results 31 to 40 of about 3,612,030 (344)

Optimality of Matched-Pair Designs in Randomized Controlled Trials [PDF]

Social Science Research Network, 2019
In randomized controlled trials, treatment is often assigned by stratified randomization. I show that among all stratified randomization schemes that treat all units with probability one half, a certain matched-pair design achieves the maximum ...
Yuehao Bai
semanticscholar   +1 more source

Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression

BMC Medicine, 2012
Background Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression.
Severus Emanuel, Seemüller Florian, Berger Michael, Dittmann Sandra, Obermeier Michael, Pfennig Andrea, Riedel Michael, Frangou Sophia, Möller Hans-Jürgen, Bauer Michael   +9 more
doaj   +1 more source

Frequent fragility of randomized controlled trials for HCC treatment

BMC Cancer, 2021
Background The fragility index (FI) of trial results can provide a measure of confidence in the positive effects reported in randomized controlled trials (RCTs). The aim of this study was to calculate the FI of RCTs supporting HCC treatments.
Hao Zhang, Jingtao Li, Wenting Zeng
doaj   +1 more source

Economic compensation interventions to increase uptake of voluntary medical male circumcision for HIV prevention: A systematic review and meta-analysis. [PDF]

, 2020
BackgroundEconomic compensation interventions may help support higher voluntary medical male circumcision (VMMC) coverage in priority sub-Saharan African countries.
Atkins, Kaitlyn, Baggaley, Rachel, Fonner, Virginia A, Kennedy, Caitlin E, O'Reilly, Kevin R, Rutherford, George W, Samuelson, Julia, Sweat, Michael D, Yeh, Ping Teresa   +8 more
core   +1 more source

The Effects of Dietary Improvement on Symptoms of Depression and Anxiety: A Meta-Analysis of Randomized Controlled Trials

Psychosomatic Medicine, 2019
Objective Poor diet can be detrimental to mental health. However, the overall evidence for the effects of dietary interventions on mood and mental well-being has yet to be assessed.
J. Firth, W. Marx, S. Dash, R. Carney, S. Teasdale, M. Solmi, B. Stubbs, F. Schuch, A. Carvalho, F. Jacka, J. Sarris   +10 more
semanticscholar   +1 more source

Analysis of the characteristics and the degree of pragmatism exhibited by pragmatic-labelled trials of antineoplastic treatments

BMC Medical Research Methodology, 2023
Background Pragmatic clinical trials (PCTs) are designed to reflect how an investigational treatment would be applied in clinical practice. As such, unlike their explanatory counterparts, they measure therapeutic effectiveness and are capable of ...
Robbe Saesen, Kevin Depreytere, Karyna Krupianskaya, Joël Langeweg, Julie Verheecke, Denis Lacombe, Isabelle Huys   +6 more
doaj   +1 more source

Segmental stabilizing exercises and low back pain: What is the evidence? [PDF]

, 2006
Study design: A systematic review of randomized controlled trials. Objectives: To evaluate the effectiveness of segmental stabilizing exercises for acute, subacute and chronic low back pain with regard to pain, recurrence of pain, disability and ...
Bie, Rob de, Ewert, Thomas, Garnier, Katharina von, Limm, Heribert, Rackwitz, Berid, Stucki, Gerold   +5 more
core   +1 more source

Electronic Versus Traditional Data Collection: A Multicenter Randomized Controlled Perioperative Pain Trial

Canadian Journal of Pain, 2019
Background: Electronic data collection is increasingly available as a means to collect pain-related clinical trial data; however, effectiveness and costs relative to traditional data collection are uncertain.
James S. Khan, Lindsay A. Jibb, Jason W. Busse, Ian Gilron, Stephen Choi, James E. Paul, Michael McGillion, Sean Mackey, D. Norman Buckley, Shun Fu Lee, P. J. Devereaux   +10 more
doaj   +1 more source

Risk of second primary cancers in cancer patients treated with cisplatin: a systematic review and meta-analysis of randomized studies

BMC Cancer, 2017
Background Case reports, retrospective analyses, and observational studies have linked the use of cisplatin to increased risk of second cancers, especially life-threatening secondary leukemia.
Fei Liang, Sheng Zhang, Hongxi Xue, Qiang Chen   +3 more
doaj   +1 more source

Understanding the Intention-to-treat Principle in Randomized Controlled Trials

Western Journal of Emergency Medicine, 2017
Clinicians, institutions, and policy makers use results from randomized controlled trials to make decisions regarding therapeutic interventions for their patients and populations.
Eric McCoy
semanticscholar   +1 more source