Conditional average treatment effect estimation with marginally constrained models [PDF]
, 2022 Treatment effect estimates are often available from randomized controlled trials as a single average treatment effect for a certain patient population. Estimates of the conditional average treatment effect (CATE) are more useful for individualized treatment decision making, but randomized trials are often too small to estimate the CATE.
arxiv +1 more source
Safety of short-term dual antiplatelet therapy after drug-eluting stents:An updated meta-analysis with direct and adjusted indirect comparison of randomized control trials [PDF]
, 2014 Background: Duration of dual antiplatelet therapy (DAPT) following drug-eluting stents (DES) remains controversial and is a topic of ongoing research.
Bulluck, Heerajnarain +3 more
core +1 more source
Randomized controlled trial of topical phenylephrine in the treatment of faecal incontinence
Journal of British Surgery, 2000 Abstract Background Anal incontinence due to internal sphincter dysfunction is not amenable to simple surgical repair. The α-adrenergic agonist phenylephrine produces contraction of the internal sphincter and raises resting pressure when applied topically in healthy volunteers.
Michael A. Kamm +2 more
openaire +3 more sources
Oral Desipramine and Topical Lidocaine for Vulvodynia [PDF]
Obstetrics & Gynecology, 2010 To estimate the efficacy of common treatments for vulvodynia: topical lidocaine monotherapy, oral desipramine monotherapy, and lidocaine-desipramine combined therapy.A 12-week randomized, double-blinded, placebo-controlled trial was conducted on 133 vulvodynia-afflicted women assigned to four treatment arms: placebo tablets-placebo cream, desipramine ...
Li-Shan Huang +8 more
openaire +3 more sources
The Effect of Schroth Therapy on Thoracic Kyphotic Curve and Quality of Life in Scheuermann’s Patients: A Randomized Controlled Trial [PDF]
Asian Spine Journal, 2019 Study Design Randomized controlled single-blinded clinical trial. Purpose To evaluate the efficacy of Schroth therapy on thoracic curve angle, pain, and self-perceived body image (SPBI) of the back in Scheuermann’s patients in comparison with the ...
Tomer Bezalel +3 more
doaj +1 more source
Vaccines, 2022 In 2014–2015, we conducted a randomized controlled trial (RCT) assessing the effect of an advertising campaign for influenza vaccination using posters and pamphlets in general practitioner (GP) waiting rooms.
Christophe Berkhout +7 more
doaj +1 more source
Trials, 2021 Background Early intensive blood pressure (BP) lowering remains the most promising treatment for acute intracerebral hemorrhage (ICH), despite discordant results between clinical trials and potential variation in the treatment effects by approach to ...
L. Song +17 more
semanticscholar +1 more source
Topical tetracaine prior to arterial puncture: a randomized, placebo-controlled clinical trial [PDF]
Respiratory Medicine, 2003 The objective of this randomized, double-blind, placebo-controlled clinical trial was to determine whether a topical anesthetic agent (tetracaine) provides effective local analgesia prior to radial arterial puncture. Tetracaine or placebo gel was applied 45 min prior to arterial puncture to patients who were referred for elective arterial blood gas ...
Mary-Jo Lewis +8 more
openaire +3 more sources
Multi-armed Bandit Models for the Optimal Design of Clinical Trials: Benefits and Challenges [PDF]
Statistical Science 2015, Vol. 30, No. 2, 199-215, 2015 Multi-armed bandit problems (MABPs) are a special type of optimal control problem well suited to model resource allocation under uncertainty in a wide variety of contexts. Since the first publication of the optimal solution of the classic MABP by a dynamic index rule, the bandit literature quickly diversified and emerged as an active research topic ...
arxiv +1 more source
Continuous Positive Airway Pressure Treatment in Patients with Alzheimer's Disease: A Systematic Review [PDF]
, 2020 Background: Epidemiological studies have suggested a pathophysiological relationship between obstructive sleep apnea syndrome (OSAS) and Alzheimer's disease (AD).
Galán Mercant, Alejandro +5 more
core +2 more sources