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Denosumab, a RANK Ligand Inhibitor, for Postmenopausal Women with Osteoporosis
Annals of Pharmacotherapy, 2012OBJECTIVE: To review the evidence for use of denosumab for the treatment of postmenopausal osteoporosis. DATA SOURCES: A search of MEDLINE and EMBASE databases was conducted during January 2012, using the terms denosumab and ...
Emily E, Sutton, Daniel M, Riche
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Crystal Structure of RANK Ligand Involved in Bone Metabolism
2004Bone remodeling involves the resorption of bone by osteoclasts and the synthesis of bone matrix by osteoblasts. Recently, an essential cytokine system for osteoclast biology has been identified and extensively characterized. This system consists of a ligand, receptor activator of NF-kappaB ligand (RANKL), a receptor, RANK, and its soluble decoy ...
Shuichiro, Ito, Tadashi, Hata
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[Inhibition of RANK ligand to treat bone metastases].
Bulletin du cancer, 2013info:eu-repo/semantics ...
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RANK ligand et métastases osseuses
2008Les cellules tumorales secretent des facteurs osteolytiques dont la plupart agissent via la production par les osteoblastes de RANKL, facteur de la differenciation des osteoclastes.
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Ranking of High‐Affinity Ligands by NMR Spectroscopy
Angewandte Chemie International Edition, 2009Xiaolu, Zhang +3 more
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