Results 231 to 240 of about 58,241 (294)

A dual-action humanized DKK-1 antibody that activates the Wnt/β-catenin signaling pathway and inhibits the RANKL signaling pathway for osteoporosis therapy. [PDF]

Front Immunol
Hou S, Gao T, Wu Y, Wang H, Zhang D, Guo Q, Xu J, Guo H, Qian W.   +8 more
europepmc   +1 more source

A Clinically Aligned Two‐Stage Machine Learning Framework for Predicting Hungry Bone Syndrome After Parathyroidectomy

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
A clinically aligned two‐stage machine learning framework integrates preoperative and perioperative features to predict hungry bone syndrome after parathyroidectomy. Explainable risk stratification may support individualised calcium management and early intervention for high‐risk patients.
Shih‐Min Yin, Yu‐Chieh Lin, Tzu‐Hsun Hung, Shen‐En Chou, Shun‐Yu Chi, Fong‐Fu Chou, Yi‐Ju Wu, Si‐Yuan Wu, Jenn‐Jier James Lien, Po‐Chih Kuo, Yi‐Chia Chan   +10 more
wiley   +1 more source

In Situ Biomineralization Enhances Mitochondrial Transplantation to Differentiating Osteoclast Precursors for Suppressing Cancer-Induced Osteolysis. [PDF]

Research (Wash D C)
Zhang Y, Liu C, Zhuang P, Li C, Zhang H, Liu Y, Chen Y, Yang W, Wu L, Du Y, Cui W, Zhang H.   +11 more
europepmc   +1 more source

Hemp (Cannabis sativa L.) Seed Protein and Its Hydrolysate Promote Bone Formation via the SMAD‐Dependent BMP Pathway

iNew Medicine, Volume 2, Issue 3, September 2026.
ABSTRACT Objective With the global increase in aging populations, the prevalence of osteoporosis is rising. Current preventive and therapeutic strategies remain limited. The present study aimed to investigate the effects of hemp seed protein (HSP) and its hydrolysis‐derived bioactive peptides (HPH) on osteogenic differentiation and to elucidate their ...
Yan Wang, Jiameng Jia, Yang Yu, Kaiyuan Zheng, Meng Deng, Wei Chen, Guoming Liu, Ping Yi, Dongning Ling, Jing Zhang, Linfeng Liu, Bing Yang, Qing Wu, Ping Wei, Chong Yin   +14 more
wiley   +1 more source

Senescent immune cells, inflammaging, and bone loss: therapeutic potential and translational challenges of senolytics in osteoporosis. [PDF]

Front Endocrinol (Lausanne)
Zhu M, Zhang J, Fang H, Cai K, Wu Q, Gao C, Wang Y, Chen J.   +7 more
europepmc   +1 more source

Nrf2–Keap1 Axis Modulation by Phytofabricated Metal Oxide Nanoparticles in Mesenchymal Stem Cell Lineage Bias

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Phytofabricated metal oxide nanoparticles may activate the Nrf2–Keap1 axis through a dual‐stimulus mechanism, coupling nanoparticle‐derived ROS with phytochemical‐mediated Keap1 modification, steering mesenchymal stem cells toward osteogenic commitment — a mechanistic framework this review consolidates from current evidence.
Muhammad Irfan, Muhammad Taha, Syed Muhammad Faizan Asghar, Muhammad Raza   +3 more
wiley   +1 more source

Estradiol Enhances Alveolar Bone Resorption by Promoting Osteoclast Differentiation in Experimental Periodontitis. [PDF]

Dent J (Basel)
Yasuda K, Matsuda S, Memida T, Yoshimoto T, Nakashima F, Ninomiya Y, Ueda T, Shimada S, Hirata-Tsuchiya S, Kajiya M, Ouhara K, Mizuno N.   +11 more
europepmc   +1 more source

Rhapontigenin Alleviates Sepsis‐Associated Acute Kidney Injury and Is Accompanied by Modulation of Ferroptosis, Inflammation, and NF‐κB Signaling

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Rha attenuates SA‐AKI. In LPS‐stimulated HK‐2 cells and CLP mice, Rha improved cell viability and reduced ferroptosis‐related changes, inflammatory responses, and NF‐κB activation. ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) is a common complication in critically ill patients and is associated with high mortality.
Jing Kuang, Xiaoyun Zhu, Jun Fang, Shuli Hu, Wei Dai, Xuepeng Fan   +5 more
wiley   +1 more source

Antioxidant, Anti-Inflammatory, and Bone-Remodeling Modulatory Activities of Thai Pigmented and Non-Pigmented Rice Bran Oils Containing Tocols and γ-Oryzanol. [PDF]

Antioxidants (Basel)
Pattananandecha T, Apichai S, Julsrigival J, Thiankhanithikun K, Ogata F, Kawasaki N, Ruangsuriya J, Saenjum C.   +7 more
europepmc   +1 more source

MPRO3 Regulates Macrophage Polarization and Osteoclastogenesis <i>In Vitro</i> and Attenuates Ligature-Induced Alveolar Bone Loss in Periodontitis. [PDF]

J Microbiol Biotechnol
Park HJ, Kim TS, Kim MK, Kim Y, Heo SC, Hong DK, Park SD, Shim JJ, Lee JH, Kim HJ, Bae SK, Bae MK.   +11 more
europepmc   +1 more source