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The effects of SARS-CoV-2 on bone homeostasis. [PDF]

open access: yesFront Endocrinol (Lausanne)
Delpino MV, Quarleri J.
europepmc   +1 more source
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RANKL biology

Bone, 2022
Since the receptor activator of nuclear factor-kappa B ligand (RANKL), its cognate receptor activator of nuclear factor-kappa B (RANK), and the decoy receptor osteoprotegerin (OPG) were discovered, a number of studies have uncovered the crucial role of the RANKL-RANK-OPG pathway in controlling the key aspect of bone homeostasis, the immune system ...
Noriko, Takegahara   +2 more
openaire   +2 more sources

RANKL and periodontitis

Folia Pharmacologica Japonica, 2023
Periodontal disease is characterized by inflammation of the periodontal tissue and subsequent destruction of the alveolar bone. It is one of the most common infectious diseases in humans, being the leading cause of tooth loss in adults. Recently, it has been shown that the receptor activator of NF-κB ligand (RANKL) produced by osteoblasts and ...
Yutaro, Ando, Masayuki, Tsukasaki
openaire   +2 more sources

RANKL and osteoimmunology in periodontitis

Journal of Bone and Mineral Metabolism, 2020
Periodontitis, one of the most common infectious diseases in humans, is characterized by inflammation of the periodontal tissue and subsequent destruction of the alveolar bone, which ultimately leads to tooth loss. Recently, it was revealed that the osteoclastic bone damage that occurs during periodontitis is dependent on the receptor activator of NF ...
openaire   +2 more sources

RANKL/RANK—beyond bones

Journal of Molecular Medicine, 2011
Receptor-activator of NF-κB ligand (TNFSF11, also known as RANKL, OPGL, TRANCE, and ODF) and its tumor necrosis factor (TNF)-family receptor RANK are essential regulators of bone remodeling, lymph node formation, establishment of the thymic microenvironment, mammary gland development during pregnancy, and bone metastasis in cancer.
Hanada   +7 more
openaire   +2 more sources

The RANKL Pathway and Denosumab

Rheumatic Disease Clinics of North America, 2011
Denosumab (Prolia) is a fully human monoclonal antibody directed against receptor activator of nuclear factor-κB ligand (RANKL), which interferes with the formation, activation, and survival of osteoclasts. It was approved by the Food and Drug Administration in June 2010 as a new treatment for postmenopausal osteoporosis in women who are at high risk ...
openaire   +2 more sources

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