Results 261 to 270 of about 88,529 (348)

Vildagliptin and Omarigliptin Differentially Bind to DPP‐4 Homodimers and Modulate Osteoclast‐Mediated Bone Resorption

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Vildagliptin and omarigliptin, dipeptidyl peptidase‐4 (DPP‐4) inhibitors, have differential effects on bone cells. Although vildagliptin improved the bone microstructure of high‐fat diet‐fed rats, it was unable to downregulate osteoclastogenesis or the expression of key osteoclast transcripts.
Ratchaneevan Aeimlapa, Jiraporn Panmanee, Jarinthorn Teerapornpuntakit, Kannikar Wongdee, Jirawan Thongbunchoo, Nattapon Panupinthu, Saovaros Svasti, Nattayaporn Apaijai, Piangkwan Sa‐nguanmoo, Siriporn Chattipakorn, Nipon Chattipakorn, Narattaphol Charoenphandhu   +11 more
wiley   +1 more source

Plant-derived food bioactives in bone health: from multi-targeted roles to molecular mechanisms in osteoporosis. [PDF]

Front Nutr
Zhang Y, Xu L, Xu H, Zhang Y, Wang L, Jiang S, Sun Y, Yu Y.   +7 more
europepmc   +1 more source

Inhibition of miR-21 restores RANKL/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts

, 2015
Maria Rita Pitari, Marco Rossi, Nicola Amodio, Cirino Botta, Eugenio Morelli, Cinzia Federico, Annamaria Gullà, Daniele Caracciolo, Maria Teresa Di Martino, Mariamena Arbitrio, Antonio Giordano, Pierosandro Tagliaferri, Pierfrancesco Tassone   +12 more
openalex   +1 more source

Oral Administration of Freeze‐Dried Lactobacillus zeae Alleviates Periodontitis by Affecting the Oral and Intestinal Flora

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
First, probiotic strain Lactobacillus zeae N165 with oral antibacterial activity, autoaggregation ability and coaggregation ability was screened through in vitro experiments. Then, in vivo efficacy evaluation was conducted on this strain, and a mouse model was used to verify its ameliorative effect on periodontitis.
Qimeng Liang, Zixin Kang, Xiaodong Song, Yuanhong Xie, Hongxing Zhang, Junhua Jin   +5 more
wiley   +1 more source

Diminished osteoprotegerin production by gingival fibroblasts from periodontitis patients is associated with their reduced ability to suppress osteoclastogenesis. [PDF]

Sci Rep
Nieboga E, Drzazga K, Plonczynska A, Drapala DM, Schuster A, Melnykova M, Skawska J, Zajdel M, Kantorowicz M, Roffel S, Cichy J, Czesnikiewicz-Guzik M, Kaczmarzyk T, Gibbs S, Potempa J, Grabiec AM.   +15 more
europepmc   +1 more source

Mechanisms of TNF-α– and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis

, 2003
Christopher T. Ritchlin, Sally A. Haas-Smith, Ping Li, David G. Hicks, Edward M. Schwarz   +4 more
openalex   +1 more source

A High Fat/High Sucrose Diet Alters the Skeletal Response to Adenine-Induced Chronic Kidney Disease in Male Rats. [PDF]

Calcif Tissue Int
Metzger CE, Tak LY, LaPlant AN, Allen MR.   +3 more
europepmc   +1 more source

Effects of Micropore Size Distribution in Carbonate Apatite Honeycomb Granules on Bone Replacement

Journal of Biomedical Materials Research Part A, Volume 114, Issue 2, February 2026.
Bone regeneration capacity of two carbonate apatite honeycombs with identical porosity but different pore size distributions. ABSTRACT Successful bone defect repair requires understanding both the role of micropores smaller than 10 μm and that of macropores.
Koichiro Hayashi, Ryo Kishida, Kunio Ishikawa   +2 more
wiley   +1 more source

Rgnef regulates bone mass through the activation of RhoA and Rac1. [PDF]

Exp Mol Med
Lee J, Lee GR, Lee HI, Kwon M, Kim T, Lee JR, Lee SY, Jeong W.   +7 more
europepmc   +1 more source

Rosuvastatin in Combination With Bortezomib Promotes Osteogenesis in Myeloma Bone Disease by Inhibiting the Secretion of CCL3

eJHaem, Volume 7, Issue 1, February 2026.
ABSTRACT Background Myeloma bone disease (MBD) is a devastating complication of multiple myeloma (MM) and a primary cause of disability in affected patients. Its pathogenesis is driven by an imbalance in bone remodeling, largely attributed to the overexpression of C‐C motif chemokine ligand 3 (CCL3). While both bortezomib and statins have been reported
Fujun Qu, Mingxu Hui, Fan Yang, Bo Huang, Nian Liu, Yuchan He, Xiaotao Wang   +6 more
wiley   +1 more source