Results 81 to 90 of about 81,008 (204)

Control of RANKL gene expression [PDF]

open access: yesBone, 2010
Osteoclasts are highly specialized cells capable of degrading mineralized tissue and form at different regions of bone to meet different physiological needs, such as mobilization of calcium, modeling of bone structure, and remodeling of bone matrix. Osteoclast production is elevated in a number of pathological conditions, many of which lead to loss of ...
openaire   +2 more sources

Congenital Adrenal Hyperplasia: A Case Report with Premature Teeth Exfoliation and Bone Resorption [PDF]

open access: yes, 2015
Congenital adrenal hyperplasia (CAH) is an inherited autosomal recessive disorder characterized by insufficient production of cortisol. The aim of this case report was to present a child with CAH, premature exfoliation of primary teeth and accelerated ...
Angelopoulou, Matina V.   +2 more
core   +1 more source

Successful Treatment of Multiple Metastatic Melanoma with Nivolumab, Ipilimumab plus Denosumab Combined Therapy

open access: yesCase Reports in Oncology, 2019
Nivolumab plus ipilimumab combined therapy is one of the promising drugs that enhance the anti- immune response in patients with advanced melanoma. Therefore, to increase its response rate is of great interest to dermatologists.
Saaya Yoshida   +5 more
doaj   +1 more source

Lattice duality for families of $K3$ surfaces associated to transpose duality [PDF]

open access: yes, 2016
The aim of this article is to show that the transpose-dual pairs in the sense of Ebeling-Ploog of singularities $(Z_{1,0},\, Z_{1,0})$, $(U_{1,0},\, U_{1,0})$, $(Q_{17},\, Z_{2,0})$, $(W_{1,0},\, W_{1,0})$ that are concluded to be polytope-dual by the ...
Mase, Makiko
core   +3 more sources

Serum markers of bone fragility in type-2 diabetes mellitus [PDF]

open access: yes, 2019
Patients with type-2 diabetes mellitus (T2DM) have normal or increased bone mineral density (BMD) but despite that, they are characterized by an increased hip and vertebral fracture risk that involves the alteration of bone quality and not the reduction ...
Dănciulescu Miulescu, Rucsandra   +5 more
core   +1 more source

RANKL blockade improves efficacy of PD1-PD-L1 blockade or dual PD1-PD-L1 and CTLA4 blockade in mouse models of cancer

open access: yesOncoImmunology, 2018
Receptor activator of NF-κB ligand (RANKL) and its receptor RANK, are members of the tumor necrosis factor and receptor superfamilies, respectively. Antibodies targeting RANKL have recently been evaluated in combination with anti-CTLA4 in case reports of
Elizabeth Ahern   +6 more
doaj   +1 more source

Mitigation of Rheumatic Arthritis in a Rat Model via Transdermal Delivery of Dapoxetine HCl Amalgamated as a Nanoplatform: In vitro and in vivo Assessment

open access: yesInternational Journal of Nanomedicine, 2020
Heba Farouk Salem,1 Mohamed Mahmoud Nafady,2 Rasha Mostafa Kharshoum,1 Omnia Ahmed Abd el-Ghafar,3 Hanan Osman Farouk2 1Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Beni- Suef University, Beni Suef, Egypt; 2Pharmaceutics and ...
Salem HF   +4 more
doaj  

Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway

open access: yesDrug Design, Development and Therapy, 2020
Ye Zhao, 1, 2 Hui-Ling Wang, 1 Tong-Tong Li, 1 Fei Yang, 1 Chi-Meng Tzeng 1 1School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211800, People’s Republic of China; 2Jiangsu Synergetic Innovation Center for Advanced Bio ...
Zhao Y, Wang HL, Li TT, Yang F, Tzeng CM
doaj  

Managerial Attitudes and the Integration of Artificial Intelligence: Impacts on Supply Chain Flexibility

open access: yesChemical Engineering Transactions
Artificial intelligence (AI) is rapidly becoming a strategic driver of competitiveness in supply chain management (SCM), enhancing flexibility, efficiency, and responsiveness.
Andrea Rankl, Péter Németh
doaj  

Known laboratory abnormalities and potential targets for the conservative treatment of avascular osteonecrosis

open access: yesСовременная ревматология
Avascular osteonecrosis (AON) is a common condition that most often affects people of working age (20–60 years). The disease leads to rapid destruction and collapse of the subchondral bone with subsequent development of secondary osteoarthritis of the ...
V. E. Bialik   +9 more
doaj   +1 more source

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