Results 61 to 70 of about 41,691 (265)

Indicators of the osteoclastogenesis system in men with different clinical types of ankylosing spondylitis

Современная ревматология, 2015
Objective: to evaluate the osteoclastogenesis regulatory system – osteoprotegerin/receptor activator of nuclear factor-κβ ligand (OPG/RANKL) system – in men with different clinical types of ankylosing spondylitis (AS).Subjects and methods.
T. A. Raskina, O. A. Pirogova, O. V. Zobnina, G. A. Pintova   +3 more
doaj   +1 more source

Biology of RANK, RANKL, and osteoprotegerin [PDF]

Arthritis Research & Therapy, 2007
The discovery of the receptor activator of nuclear factor-kappaB ligand (RANKL)/RANK/osteoprotegerin (OPG) system and its role in the regulation of bone resorption exemplifies how both serendipity and a logic-based approach can identify factors that regulate cell function. Before this discovery in the mid to late 1990s, it had long been recognized that
Boyce, Brendan F, Xing, Lianping
openaire   +2 more sources

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang

Open Medicine
Obesity has been recognized as a global epidemic and public health crisis. The prevalence of obesity has tripled since 1975, especially in the elderly population.
Liu Jinling, Xiao Wenwen, Halan Buluhan, Wumaer Aishanjiang, Maimaitiwusiman Zhuoya, Xuekelati Saiyare, Musha Tajiguli, Bai Xue, Wang Hongmei   +8 more
doaj   +1 more source

Exploring the Role of Exosomes in Accelerating Orthodontic Tooth Movement

Journal of Pharmacy and Bioallied Sciences
Background: Alveolar bone remodeling is a complicated biological process that is involved in orthodontic tooth movement (OTM). Recent studies have shown how exosomes, which are cell-secreted nanovesicles, influence cellular communication and encourage ...
Abdalwhab Zwiri, Mohammad Khursheed Alam, Mohammad Younis Hajeer, Ebtehal Dhyab M. Alserhani, Dalia Abdulrahman Alanazi, Jinan Mohammed Alanazi, Nor Farid Bin Mohd Noor, Zafrina Islam   +7 more
doaj   +1 more source

Discontinuing Long‐Term Denosumab in Treating Fragile Bone: Why, for Whom, and How?

Clinical Pharmacology &Therapeutics, EarlyView.
Discontinuation of denosumab (Dmab) may be necessary due to adverse events or an unfavorable long‐term risk–benefit profile. However, accumulating evidence demonstrates pronounced rebound phenomena after withdrawal, most notably a marked increase in multiple vertebral fractures, and, in some reports, elevated mortality.
Ko‐Hsiu Lu, Renn‐Chia Lin, Ing‐Lin Chang, Shau‐Huai Fu, Meng‐Ying Tsai, Shun‐Fa Yang   +5 more
wiley   +1 more source

Predictive analysis and prediction of the main molecular targets for the N-acetyl-6-aminohexanoate derivative

Research Results in Pharmacology
Introduction: N-acetyl-6-aminohexanoate (acexamic acid) and its derivatives are actively studied as promising compounds for the creation of new drugs, but their pharmacokinetic parameters and detailed mechanisms underlying a wide range of biochemical ...
Anton P. Danilenko, Alexey A. Khentov, Alexey V. Kuznetsov, Veronika S. Shmigerova, Yulia V. Stepenko, Alla P. Tarasova, Vladimir I. Yakushev, Elizaveta V. Boeva, Albina V. Miller, Irina A. Tatarenkova, Tatiana V. Puzanova, Yana V. Loboda, Andrei P. Trashchenko, Oleg S. Gudyrev, Anna L. Motailo, Vladimir N. Kuzichkin, Valentina N. Milashechko, Lyudmila M. Danilenko   +17 more
doaj   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Smart Nanodelivery Systems for Immunometabolic Modulation in Osteoarthritis

Exploration, EarlyView.
Smart nanodelivery systems deliver therapeutic payloads across the cartilage matrix to ensure their sustained accumulation within chondrocytes at sites of injury. By targeting specific molecular targets and signaling pathways, these platforms modulate the pathological synovium‐cartilage axis to restore immunometabolic homeostasis and drive tissue ...
Qirui Zhao, Zhewen Mi, Shuya Liu, Shijun Liang, Linjia Peng, Zixuan Gao, Jiaming Li, Xiaoqing Lu, Zhiguang Ren, Yongjie Wan, Shengsheng Cui, Longlong Lu, Xiaoyang Gao, Tao Wang, Hui Liang, Furong Tian, de la Fuente Jesus M, Chong Xiang, Luyi Sun, Lichen Xiang, Daxiang Cui   +20 more
wiley   +1 more source

Peri‐implant disease pathogenesis animal models: Consensus report of Workgroup 1 of the IADR Implantology Research Group Best Evidence Consensus Symposium on Peri‐Implant Disease and Its Treatment

Journal of Periodontology, EarlyView.
Abstract Background The pathogenesis and etiology of peri‐implantitis demand a deeper understanding to lead to successful treatment modalities. Animal models of peri‐implantitis pathogenesis offer unique insights but their translational impact requires consideration of implant biomaterials science.
Georgios Kotsakis, Leonardo Mancini, Panos Afouxenides, Andrea Roccuzzo, IADR IRG Peri‐implantitis Best Evidence Consensus Working Group 1, Tara Aghaloo, Georgios Belibasakis, Nagihan Bostanci, Li Dehua, Nikolaos Donos, Alpdogan Kantarci, Alireza Moshaverinia, Flavia Pirih, Mia Rakic, Frank Schwarz, Sukirth Ganesan   +15 more
wiley   +1 more source