Results 61 to 70 of about 59,926 (291)

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

Indicators of the osteoclastogenesis system in men with different clinical types of ankylosing spondylitis

Современная ревматология, 2015
Objective: to evaluate the osteoclastogenesis regulatory system – osteoprotegerin/receptor activator of nuclear factor-κβ ligand (OPG/RANKL) system – in men with different clinical types of ankylosing spondylitis (AS).Subjects and methods.
T. A. Raskina, O. A. Pirogova, O. V. Zobnina, G. A. Pintova   +3 more
doaj   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation [PDF]

Advanced science
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Liang H, Xiao Y, Luo J, Yang X, Yang Y, Wu Q, Yu C, Zhou Z, Si X, Miao J, Tu Y, Lu Q, Qian B, Wang X, Xu J, Shi C, Jin H.   +16 more
europepmc   +2 more sources

RANKL-independent osteoclastogenesis in the SH3BP2 cherubism mice [PDF]

, 2020
Even though the receptor activator of the nuclear factor-κB ligand (RANKL) and its receptor RANK have an exclusive role in osteoclastogenesis, the possibility of RANKL/RANK-independent osteoclastogenesis has been the subject of a long-standing debate in ...
Levitan, Marcus Evan, Ueki, Yasuyoshi, Kittaka, Mizuho, Yoshimoto, Tetsuya, Hoffman, Henry   +4 more
core   +1 more source

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source

Exploring the Role of Exosomes in Accelerating Orthodontic Tooth Movement

Journal of Pharmacy and Bioallied Sciences
Background: Alveolar bone remodeling is a complicated biological process that is involved in orthodontic tooth movement (OTM). Recent studies have shown how exosomes, which are cell-secreted nanovesicles, influence cellular communication and encourage ...
Abdalwhab Zwiri, Mohammad Khursheed Alam, Mohammad Younis Hajeer, Ebtehal Dhyab M. Alserhani, Dalia Abdulrahman Alanazi, Jinan Mohammed Alanazi, Nor Farid Bin Mohd Noor, Zafrina Islam   +7 more
doaj   +1 more source

Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang

Open Medicine
Obesity has been recognized as a global epidemic and public health crisis. The prevalence of obesity has tripled since 1975, especially in the elderly population.
Liu Jinling, Xiao Wenwen, Halan Buluhan, Wumaer Aishanjiang, Maimaitiwusiman Zhuoya, Xuekelati Saiyare, Musha Tajiguli, Bai Xue, Wang Hongmei   +8 more
doaj   +1 more source

Predictive analysis and prediction of the main molecular targets for the N-acetyl-6-aminohexanoate derivative

Research Results in Pharmacology
Introduction: N-acetyl-6-aminohexanoate (acexamic acid) and its derivatives are actively studied as promising compounds for the creation of new drugs, but their pharmacokinetic parameters and detailed mechanisms underlying a wide range of biochemical ...
Anton P. Danilenko, Alexey A. Khentov, Alexey V. Kuznetsov, Veronika S. Shmigerova, Yulia V. Stepenko, Alla P. Tarasova, Vladimir I. Yakushev, Elizaveta V. Boeva, Albina V. Miller, Irina A. Tatarenkova, Tatiana V. Puzanova, Yana V. Loboda, Andrei P. Trashchenko, Oleg S. Gudyrev, Anna L. Motailo, Vladimir N. Kuzichkin, Valentina N. Milashechko, Lyudmila M. Danilenko   +17 more
doaj   +1 more source

Effects of RANKL on the thymic medulla [PDF]

European Journal of Immunology, 2011
AbstractThe thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs) contribute to the establishment of self‐tolerance by the deletion of self‐reactive T cells and the generation of regulatory T cells. The progression of thymocyte development critically regulates the optimum formation of the thymic medulla, as ...
Izumi, Ohigashi, Takeshi, Nitta, Enkhsaikhan, Lkhagvasuren, Hisataka, Yasuda, Yousuke, Takahama   +4 more
openaire   +2 more sources