Results 81 to 90 of about 58,241 (294)

RANKL blockade improves efficacy of PD1-PD-L1 blockade or dual PD1-PD-L1 and CTLA4 blockade in mouse models of cancer

OncoImmunology, 2018
Receptor activator of NF-κB ligand (RANKL) and its receptor RANK, are members of the tumor necrosis factor and receptor superfamilies, respectively. Antibodies targeting RANKL have recently been evaluated in combination with anti-CTLA4 in case reports of
Elizabeth Ahern, Heidi Harjunpää, Jake S. O'Donnell, Stacey Allen, William C. Dougall, Michele W. L. Teng, Mark J. Smyth   +6 more
doaj   +1 more source

Bifunctional injectable selenium‐containing polyurethane hydrogels for periodontal regeneration through endoplasmic reticulum stress modulation

BMEMat, EarlyView.
Graphical illustration of the synthesis, biological functions and mechanisms of bifunctional injectable selenium‐containing polyurethane hydrogels. Abstract Periodontitis causes progressive destruction of both periodontal soft and hard tissues, leading to tooth loss and functional impairment.
Mingchu Zhao, Mo Zhai, Zhuoxin Ge, Xiaodong Guo, Zhuqing Wan, Xiaoqiang Bai, Huaping Xu, Yongsheng Zhou, Longwei Lv   +8 more
wiley   +1 more source

RANKL outcomes.

, 2020
RANKL outcomes.
Andrés López Roldán (8362788), Francisco Alpiste Illueca (8362794), José Luis García Giménez (8362791)   +2 more
core   +2 more sources

RANKL/OPG outcomes.

, 2020
Fig 3. Evolution of the RANKL/OPG ratio according to the group and time point: control group (RANKL/OPG) and study group before (T1) and after (T2) basic periodontal treatment.
Andrés López Roldán (8362788), Francisco Alpiste Illueca (8362794), José Luis García Giménez (8362791)   +2 more
core   +1 more source

Caveolin‐1 enriched apoptotic bodies derived from oral hard palate orchestrate bone remodeling to treat heterotopic ossification

BMEMat, EarlyView.
Downregulated CAV1 in HO is restored via apoptotic bodies from PMSCs, which reprogram bone remodeling by delivering CAV1 to target cells, highlighting the therapeutic role of EV subtypes in heterotopic ossification. Abstract Heterotopic ossification (HO) is a pathological process characterized by ectopic bone formation in non‐osseous tissues, with an ...
Yuchen Wang, Like Tang, Zhou Yu, Wenjin Cai, Qifeng Jiang, Zhikang Wang, Yitong Chen, Kaichen Lai, Ying Wang, Tim Forouzanfar, Chiyuan Ma, Gang Wu, Tingben Huang, Guoli Yang   +13 more
wiley   +1 more source

The system of osteoprotegrin (OPG)/ligand of NF-kB receptor activator (RANKL) in patients with diabetes mellitus, mediacalcinosis and obliteratingatherosclerosis of lower leg arteries

Сахарный диабет, 2009
Aim. To study the OPG/RANKL system in patients with diabetes mellitus, mediacalcinosis and obliterating atherosclerosis of lower leg arteries. Materials and methods. The study enrolled 70 patients including 20 with manifest diabetic neuropathy (DN) and
Марианна Viktorovna Yaroslavtseva, Irina Nikolaevna Ul'yanova, Gagik Radikovich Galstyan, A V Ilin, L V Nikankina, Oleg Valer'evich Remizov, Ivan Ivanovich Dedov   +6 more
doaj   +1 more source

Strontium-substituted sub-micron bioactive glasses inhibit ostoclastogenesis through suppression of RANKL-induced signaling pathway

, 2020
Strontium-substituted bioactive glass (Sr-BG) has shown superior performance in bone regeneration. Sr-BG-induced osteogenesis has been extensively studied; however, Sr-BG-mediated osteoclastogenesis and the underlying molecular mechanism remain unclear ...
Huang, D, Zhang, W, Zhao, F, Gao, W, Chen, X, Guo, Z   +5 more
core   +1 more source

Synthesis of β‐ and γ‐Carbolinones Through a Fe(III)‐Mediated Radical 6‐Endo‐Trig Cyclization of Indole‐Based Ugi 4‐CR Adducts

European Journal of Organic Chemistry, EarlyView.
A practical strategy for synthesizing β‐ and γ‐carbolinones from indole‐based Ugi 4‐CR adducts through an intramolecular radical cyclization using Fe(III)–H species is presented. This approach enables the efficient synthesis of spiro‐carbolinones under mild reaction conditions and demonstrates the effectiveness of secondary radicals in both cyclization
María F. Olvera‐Granados, Luis A. Polindara‐García   +1 more
wiley   +1 more source

RANKL, OPG, and RUNX2 expression and epigenetic modifications in giant cell tumour of bone in 32 patients: association with clinicopathological characteristics and recurrence

Bone & Joint Research
Aims: The present study investigated receptor activator of nuclear factor kappa-Β ligand (RANKL), osteoprotegerin (OPG), and Runt-related transcription factor 2 (RUNX2) gene expressions in giant cell tumour of bone (GCTB) patients in relationship with ...
Raja Amri, Ameni Chelly, Mariem Ayedi, Mohammed A. Rebaii, Sami Aifa, Sabeur Masmoudi, Hassib Keskes   +6 more
doaj   +1 more source

The role of osteoblast cells in the pathogenesis of unicameral bone cysts

, 2012
PurposeThe pathogenesis of unicameral bone cysts (UBCs) remains largely unknown. Osteoclasts have been implicated, but the role of osteoblastic cells has, to date, not been explored.
Tayton, Edward R, Fowler, Darren J., Edward D. Gent, Richard O. C. Oreffo, Smith, James O., Oreffo, Richard O.C., Caroline J. Edwards, Edward R. Tayton, James O. Smith, Aarvold, Alexander, Darren J. Fowler, Gent, Edward D., Edwards, Caroline J., Alexander Aarvold   +13 more
core   +1 more source