Results 51 to 60 of about 59,926 (291)

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

RANKL outcomes.

, 2020
Fig 1 Mean concentration of RANKL (pg/ml) in the control group (RANKL) and the study group before (T1) and after the basic periodontal treatment (T2) at the healthy location (RANKL_HL) and the pathologic location of the subjects with periodontitis ...
Andrés López Roldán (8362788), Francisco Alpiste Illueca (8362794), José Luis García Giménez (8362791)   +2 more
core   +2 more sources

Internal inflammatory root resorption in permanent teeth

Эндодонтия Today, 2020
Internal inflammatory root resorption is a rare find in everyday dental practice. Also, it is known to be an accident discovery. Analysis of publications of domestic and foreign periodicals and of biochemistry, histology, microbiology textbooks has ...

doaj  

The Molecular Mechanisms Study of Engeletin Suppresses RANKL-Induced Osteoclastogenesis and Inhibits Ovariectomized Murine Model Bone Loss

Journal of Inflammation Research, 2023
Mingzhe Feng,1,* Lin Liu,2,* Jiang Wang,1 Jialang Zhang,1 Zechao Qu,1 Yanjun Wang,3 Baorong He1 1Department of Spine Surgery, Honghui Hospital, School of Medicine, Xi’an Jiao Tong University, Xi’an, People’s Republic of China; 2Department of ...
Feng M, Liu L, Wang J, Zhang J, Qu Z, Wang Y, He B   +6 more
doaj  

The role of denosumab in the complex treatment of giant cell tumor of the spine: reducing of local recurrence rate, surgery time and blood loss

Хирургия позвоночника, 2021
Objective. To assess the effect of the combined treatment method including preoperative denosumab therapy on the results of treatment of patients with giant cell tumors of the spine. Material and Methods.
Anastasia A. Tararykova, Aleksandr A. Fedenko, Elmar R. Musaev, Aslan K. Valiev, Ruslan M. Kabardaev, Kirill A. Borzov, Valeria I. Melnikova   +6 more
doaj   +1 more source

Hierarchical Nanoplatform Integrating Oxidative–Acidic Microenvironment Remodeling and Bone Homeostasis Modulation for Diabetic Bone Defect Therapy

Advanced Science, EarlyView.
A hierarchical CM/LDH nanoplatform integrates ROS‐scavenging Ce‐MOF nanozymes with acid‐neutralizing CaAl‐LDH and is delivered within GelMA hydrogel to diabetic bone defects. By remodeling the oxidative‐acidic microenvironment, preserving mitochondrial homeostasis, and suppressing mtDNA–cGAS–STING inflammatory signaling, CM/LDH reduces proinflammatory ...
Xu Chen, Xingyu Zhu, Zhixin Qiu, Yijia Zhu, Xinhui Zheng, Dongqi Fan, Jinglei Zhan, Congxiu Mao, Ping Ji, Tao Chen, Qingqing He   +10 more
wiley   +1 more source

Oroxin B Attenuates Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Formation and Activity

Drug Design, Development and Therapy, 2021
Jun-ming Huang, Chen-zhong Wang, Shun-yi Lu, Zhe Wang, Zuo-qin Yan Department of Orthopaedics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of ChinaCorrespondence: Zuo-qin Yan 180 Feng Lin Road, Xuhui District, Shanghai ...
Huang JM, Wang CZ, Lu SY, Wang Z, Yan ZQ
doaj  

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source

EFFECT OF GOLIMUMAB ON IMMUNOLOGICAL MARKERS FOR BONE METABOLISM AND ON ARTERIAL STIFFNESS IN PATIENTS WITH RHEUMATOID ARTHRITIS

Научно-практическая ревматология, 2018
Objective: to evaluate the effect of golimumab (GLM) on the receptor activator of NF-κB ligand (RANKL)/osteoprotegerin (OPG) transmembrane molecular system and arterial stiffness in patients with rheumatoid arthritis (RA).Subjects and methods. Thirty-six
L. A. Knyazeva, N. Damjanov, L. I. Knyazeva, N. S. Meshcherina, I. I. Goryainov   +4 more
doaj   +1 more source

RANKL regulates male reproductive function

, 2021
Infertile men have few treatment options. Here, we demonstrate that the transmembrane receptor activator of NF-kB ligand (RANKL) signaling system is active in mouse and human testis.
Andreassen, Christine Hjorth, Schwarz, Peter, Jørgensen, Anne, Boisen, Ida Marie, Juul, Anders, Toppari, Jorma, Nielsen, John Erik, Baron, Roland, Blomberg Jensen, Martin, Juel Mortensen, Li, Lanske, Beate   +10 more
core   +1 more source