Results 51 to 60 of about 41,691 (265)

Association of Hemoglobin and Iron Overload with Bone Turnover Markers in β-Thalassemia Major Patients: A Novel Biomarker Approach

Journal of Applied Hematology
BACKGROUND: β-thalassemia major is a severe genetic disorder characterized by chronic anemia and iron overload due to frequent transfusions. These pathological changes can significantly disrupt bone metabolism, increasing the risk of osteoporosis and ...
Murtadha Ali Nazzal, Abdulkareem M. Jewad, Hasan Abd Ali Khudhair   +2 more
doaj   +1 more source

Oroxin B Attenuates Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Formation and Activity

Drug Design, Development and Therapy, 2021
Jun-ming Huang, Chen-zhong Wang, Shun-yi Lu, Zhe Wang, Zuo-qin Yan Department of Orthopaedics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of ChinaCorrespondence: Zuo-qin Yan 180 Feng Lin Road, Xuhui District, Shanghai ...
Huang JM, Wang CZ, Lu SY, Wang Z, Yan ZQ
doaj  

RANKL inhibits activation of hepatic stellate cells during hepatic fibrosis in mice

陆军军医大学学报, 2023
Objective To explore the biological role of receptor activator of nuclear factor kappa-B ligand (RANKL) in the activation of hepatic stellate cells (HSCs) and the process of hepatic fibrosis.
ZHOU Lijia, ZHONG Li, XUE Qian, DENG Liang, HUANG Lu   +4 more
doaj   +1 more source

Anti‐Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap‐Mediated Bone Loss in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Shuichiro Nakabo, Norio Hanata, Eduardo Patino‐Martinez, Ronald Holewinski, Ana Barrera‐Vargas, Javier Merayo‐Chalico, Scott A. Coonrod, David A. Fox, Mariana J. Kaplan, Carmelo Carmona‐Rivera   +9 more
wiley   +1 more source

Immunomodulatory effects of curcumin on receptor activator of nuclear factor-kappa B ligand in periodontitis

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
Periodontitis is a chronic inflammatory disease of the tooth-supporting structures, often causing alveolar bone loss due to increased osteoclast activity mediated by receptor activator of nuclear factor-kappa B ligand.
Fiki Muhammad Ridho
doaj   +1 more source

Identification of marker proteins in preterm and term birth: Relationship of rankl and HSP70 in the cord blood

Medicine Science, 2022
The goal of this research was to investigate at the expression profiles of heat shock protein 70 (HSP70) and receptor activator of nuclear factor-kappa B ligand (RANKL) in term and preterm infants.
Baris Uzunok, Selcuk Gurel
doaj   +1 more source

2D copper nanozyme patches facilitate bone regeneration via interfacial modulation of osteoclast‐osteoblast dynamics

BMEMat, EarlyView.
This study develops a nano‐enzyme patch (ezPatch) targeting bone interfaces. Utilizing ligand‐to‐metal charge transfer (LMCT) catalysis and bone‐targeting ligands on copper nanosheets, ezPatch simultaneously scavenges reactive oxygen species (ROS) and generates oxygen in situ at bone‐losing sites.
Yi Chen, Haoyue Hu, Danyang Wang, Ying Wang, Zhibang Li, Xiaoyi Liu, Yandi Zhang, Junkun Feng, Weiwei Zhao, Kai Li, Qi‐Zhi Zhong, Shaohua Ge, Jianhua Li   +12 more
wiley   +1 more source

EFFECT OF GOLIMUMAB ON IMMUNOLOGICAL MARKERS FOR BONE METABOLISM AND ON ARTERIAL STIFFNESS IN PATIENTS WITH RHEUMATOID ARTHRITIS

Научно-практическая ревматология, 2018
Objective: to evaluate the effect of golimumab (GLM) on the receptor activator of NF-κB ligand (RANKL)/osteoprotegerin (OPG) transmembrane molecular system and arterial stiffness in patients with rheumatoid arthritis (RA).Subjects and methods. Thirty-six
L. A. Knyazeva, N. Damjanov, L. I. Knyazeva, N. S. Meshcherina, I. I. Goryainov   +4 more
doaj   +1 more source

Assessment of Salivary Levels of the RANKL and RANK in Patients with Healthy Gingiva on Reduced Periodontium Versus Periodontitis: An Analytical Cross-Sectional Study

Dental Hypotheses, 2023
Introduction: We aimed to compare the changes in the two salivary biomarkers, RANKL and RANK, among patients with healthy gingiva on reduced periodontium versus generalized periodontitis stages II and III.
Shurooq Abdulkareem Muhssin, Hadeel Mazin Akram   +1 more
doaj   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source