Results 41 to 50 of about 59,926 (291)

Inducible expression of RANKL in transgenic pigs under the control of the Tet-On system [PDF]

, 2011
Because of the tremendous need for transgenic large animal models for human diseases, the process of SCNT is a crucial step in transgenic pig production.
Schilling, Eleonore
core   +1 more source

Association of NFKB1, NKX2-5, GATA4 and RANKL gene polymorphisms with sporadic congenital heart disease in Greek patients

Balkan Journal of Medical Genetics, 2021
Congenital heart disease (CHD) is a group of structural defects of the heart and the great vessels, and one of the leading causes of death among infants and young adults.
Aidinidou L, Chatzikyriakidou A, Giannopoulos A, Karpa V, Tzimou I, Aidinidou E, Fidani L   +6 more
doaj   +1 more source

Molecular Triad RANK/ RANKL/ OPG in Mandible and Femur of Wistar Rats (Rattus norvegicus) With Type 2 Diabetes Mellitus [PDF]

, 2019
A successful treatment of dental implant needs a good jaw bone support, which depends on healthy bone metabolism. Bone metabolism can be affected by Diabetes Mellitus (DM). It may trigger various complications, including osteoporosis.
Primarinda D. Hapsari, Rostiny, Abil Kurdi, Ratri Maya Sitalaksmi, Muhammad D.A. Ari, Nike Hendrijantini, Puthi Y.I. Sati, Valentina V. Arief   +7 more
core   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Association of Hemoglobin and Iron Overload with Bone Turnover Markers in β-Thalassemia Major Patients: A Novel Biomarker Approach

Journal of Applied Hematology
BACKGROUND: β-thalassemia major is a severe genetic disorder characterized by chronic anemia and iron overload due to frequent transfusions. These pathological changes can significantly disrupt bone metabolism, increasing the risk of osteoporosis and ...
Murtadha Ali Nazzal, Abdulkareem M. Jewad, Hasan Abd Ali Khudhair   +2 more
doaj   +1 more source

RANKL-treatment induces the earlier accumulation of prions in lymphoid tissues after oral exposure.

, 2016
C57BL/6 mice were treated daily for 4 d with RANKL (or PBS as a control) to induce M cell-differentiation, and orally-exposed to a moderate (1%) dose of ME7 scrapie prions between the 3rd and 4th treatments.
Ifor R. Williams (2620966), Anuj Sehgal (618274), David S. Donaldson (618280), Neil A. Mabbott (190825), Daniel Rios (1630432)   +4 more
core   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Immunomodulatory effects of curcumin on receptor activator of nuclear factor-kappa B ligand in periodontitis

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
Periodontitis is a chronic inflammatory disease of the tooth-supporting structures, often causing alveolar bone loss due to increased osteoclast activity mediated by receptor activator of nuclear factor-kappa B ligand.
Fiki Muhammad Ridho
doaj   +1 more source

Biology of RANK, RANKL, and osteoprotegerin [PDF]

Arthritis Research & Therapy, 2007
The discovery of the receptor activator of nuclear factor-kappaB ligand (RANKL)/RANK/osteoprotegerin (OPG) system and its role in the regulation of bone resorption exemplifies how both serendipity and a logic-based approach can identify factors that regulate cell function. Before this discovery in the mid to late 1990s, it had long been recognized that
Boyce, Brendan F, Xing, Lianping
openaire   +2 more sources

Effect of smoking on concentrations of RANKL and OPG in human gingival crevicular fluid. [PDF]

, 2009
Background and Objective: Smoking is one of the major risk factors for chronic periodontitis. However, the mechanisms involved in tissue degradation due to cigarette smoking are not clear.
Tang, Teck Huah
core