Results 1 to 10 of about 315,545 (404)

Rapamycin: Drug Repurposing in SARS-CoV-2 Infection [PDF]

Pharmaceuticals, 2021
Since December 2019, SARS-CoV-2 (COVID-19) has been a worldwide pandemic with enormous consequences for human health and the world economy. Remdesivir is the only drug in the world that has been approved for the treating of COVID-19.
Jiri Patocka, Kamil Kuca, Patrik Oleksak, Eugenie Nepovimova, Martin Valis, Michal Novotny, Blanka Klimova   +6 more
doaj   +2 more sources

Short-Term Autophagy Preconditioning Upregulates the Expression of COX2 and PGE2 and Alters the Immune Phenotype of Human Adipose-Derived Stem Cells In Vitro

Cells, 2022
Human adipose-derived stem cells (hASCs) are potent modulators of inflammation and promising candidates for the treatment of inflammatory and autoimmune diseases. Strategies to improve hASC survival and immunoregulation are active areas of investigation.
Rachel M. Wise, Sara Al-Ghadban, Mark A. A. Harrison, Brianne N. Sullivan, Emily R. Monaco, Sarah J. Aleman, Umberto M. Donato, Bruce A. Bunnell   +7 more
doaj   +1 more source

Rapamycin treatment induces tubular proteinuria: role of megalin-mediated protein reabsorption

Frontiers in Pharmacology, 2023
Introduction: Rapamycin is an immunosuppressor that acts by inhibiting the serine/threonine kinase mechanistic target of rapamycin complex 1. Therapeutic use of rapamycin is limited by its adverse effects.
Rodrigo A. S. Peres, Diogo B. Peruchetti, Rodrigo P. Silva-Aguiar, Douglas E. Teixeira, Carlos P. Gomes, Carlos P. Gomes, Christina M. Takiya, Ana Acacia S. Pinheiro, Ana Acacia S. Pinheiro, Celso Caruso-Neves, Celso Caruso-Neves, Celso Caruso-Neves   +11 more
doaj   +1 more source

Mixed Polymeric Micelles for Rapamycin Skin Delivery

Pharmaceutics, 2022
Facial angiofibromas (FA) are one of the most obvious cutaneous manifestations of tuberous sclerosis complex. Topical rapamycin for angiofibromas has been reported as a promising treatment. Several types of vehicles have been used hitherto, but polymeric
Guillaume Le Guyader, Bernard Do, Ivo B. Rietveld, Pascale Coric, Serge Bouaziz, Jean-Michel Guigner, Philippe-Henri Secretan, Karine Andrieux, Muriel Paul   +8 more
doaj   +1 more source

Isolated Components From Spider Venom Targeting Human Glioblastoma Cells and Its Potential Combined Therapy With Rapamycin

Frontiers in Molecular Biosciences, 2022
Glioblastomas (GBs) are responsible for a higher mortality rate among gliomas, corresponding to more than 50% of them and representing a challenge in terms of therapy and prognosis.
Marcus Caballero, Marcus Caballero, Natalia Barreto, Natalia Barreto, Amanda Pires Bonfanti, Amanda Pires Bonfanti, Jaqueline Munhoz, Jaqueline Munhoz, Thomaz Rocha e Silva, Rafael Sutti, Liana Verinaud, Felipe Cezar Pinheiro de Mato, Felipe Cezar Pinheiro de Mato, Guilherme Pauperio Lanfredi, Catarina Rapôso   +14 more
doaj   +1 more source

Two-dimensional ultrathin Ti3C2 MXene nanosheets coated intraocular lens for synergistic photothermal and NIR-controllable rapamycin releasing therapy against posterior capsule opacification

Frontiers in Bioengineering and Biotechnology, 2022
Posterior capsule opacification (PCO) is one of the most frequent late-onset complications after cataract surgery. Several kinds of drug-eluting intraocular lenses (IOL) were designed for sustainable drug release to suppress ocular inflammation, the ...
Zi Ye, Yang Huang, Yang Huang, Jinglan Li, Tianju Ma, Lixiong Gao, Huihui Hu, Qing He, Haiying Jin, Zhaohui Li   +9 more
doaj   +1 more source

Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast

Cells, 2021
Cells have developed response systems to constantly monitor environmental changes and accordingly adjust growth, differentiation, and cellular stress programs.
John-Patrick Alao, Luc Legon, Charalampos Rallis   +2 more
doaj   +1 more source

Cell cycle progression or translation control is not essential for vesicular stomatitis virus oncolysis of hepatocellular carcinoma. [PDF]

, 2010
The intrinsic oncolytic specificity of vesicular stomatitis virus (VSV) is currently being exploited to develop alternative therapeutic strategies for hepatocellular carcinoma (HCC). Identifying key regulators in diverse transduction pathways that define
A Bianchini, A Villanueva, Alexandra Junger, Antonia Rizzani, DA Altomare, EF Dunn, Enrico N. De Toni, Günter Schneider, HG Wendel, I Fabregat, I Nicoletti, IBCJ Rosenwald, JE Dancey, Jennifer Altomonte, JH Connor, JS Orlando, K Shinozaki, K Shinozaki, L Mishra, LM Schang, M Ahmed, M Hidalgo, M Ikeda, M Sun, Maciej Lesniak, N Kato, N Kato, N Kemeny, N Sonenberg, NA Hamid, Nobuyuki Kato, O Ebert, O Ebert, O Larsson, Oliver Ebert, P Chakraborty, P Newell, PC Chiang, PL Hallenbeck, RB Kjellerup, RL Silva, RM Memmott, Roland M. Schmid, S Balachandran, S Joshi, S Marozin, S Oliere, S Sei, S Sell, Sabrina Marozin, SM Steinberg, SR Kimball, T Cascone, T Nakamura, T Ueda, TL Nguyen, TP Cripe, WE Thasler, Wolfgang E. Thasler, XQ Lun, Y Ma   +60 more
core   +11 more sources

Therapeutic effect of autophagy induced by rapamycin versus intermittent fasting in animal model of fatty liver

Folia Histochemica et Cytobiologica, 2023
INTRODUCTION: High-fructose, high-fat diet consumption (HFHF) is one of the primary causes of non-alcoholic fatty liver disease (NAFLD), which is due to impaired beta-oxidation or apolipoprotein secretion by hepatocytes.
Sara Adel Hosny, Mohammed Hafez Ahmed Moustafa, Fatma Mahmoud Mehina, Marwa Mohamed Sabry   +3 more
doaj   +1 more source

A Curvilinear-Path Umbrella Sampling Approach to Characterizing the Interactions Between Rapamycin and Three FKBP12 Variants

Frontiers in Molecular Biosciences, 2022
Rapamycin is an immunosuppressant macrolide that exhibits anti-proliferative properties through inhibiting the mTOR kinase. In fact, the drug first associates with the FKBP12 enzyme before interacting with the FRB domain of its target.
Dhananjay C. Joshi, Charlie Gosse, Shu-Yu Huang, Jung-Hsin Lin, Jung-Hsin Lin, Jung-Hsin Lin, Jung-Hsin Lin, Jung-Hsin Lin   +7 more
doaj   +1 more source