Results 1 to 10 of about 154,896 (150)
Journal of Dermatology and Dermatologic Surgery, 2022 Lymphatic malformation (LM) of the body surface causes symptoms such as bleeding, pain, lymphatic leakage, or infection of the lesion, usually treated with surgical resection and sclerotherapy, with limited efficacy. The vesicles of the body surface tend
Yuki Isozaki +6 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2022 Platinum-based chemotherapeutic treatment of cancer patients is associated with debilitating adverse effects. Several adverse effects have been well investigated, and can be managed satisfactorily, but chemotherapy-induced peripheral neuropathy (CIPN ...
Moureq Alotaibi +12 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background: Immunoglobulin A nephropathy (IgAN) is the most common glomerular disease worldwide. Its pathological features include IgA immune complex deposition, accompanied by mesangial cell proliferation and mesangial matrix expansion.
Xiaodong Zhu +6 more
doaj +1 more source
Wood-Derived Vascular Patches Loaded With Rapamycin Inhibit Neointimal Hyperplasia
Frontiers in Bioengineering and Biotechnology, 2022 Background: Patches are commonly used to close blood vessels after vascular surgery. Most currently used materials are either prosthetics or animal-derived; although natural materials, such as a leaf, can be used as a patch, healing of these natural ...
Boao Xie +8 more
doaj +1 more source
Frontiers in Microbiology, 2022 Hepatitis B virus (HBV) infection is still a serious public health problem worldwide. Antiviral therapies such as interferon and nucleos(t)ide analogs efficiently control HBV replication, but they cannot eradicate chronic hepatitis B (CHB) because of ...
Yuan Zhang +18 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 Rapamycin is an immunosuppressant macrolide that exhibits anti-proliferative properties through inhibiting the mTOR kinase. In fact, the drug first associates with the FKBP12 enzyme before interacting with the FRB domain of its target.
Dhananjay C. Joshi +7 more
doaj +1 more source
Delineation of proteome changes driven by cell size and growth rate
Frontiers in Cell and Developmental Biology, 2022 Increasing cell size drives changes to the proteome, which affects cell physiology. As cell size increases, some proteins become more concentrated while others are diluted. As a result, the state of the cell changes continuously with increasing size.
Evgeny Zatulovskiy +7 more
doaj +1 more source
mTORC1-Mediated Angiogenesis is Required for the Development of Rosacea
Frontiers in Cell and Developmental Biology, 2021 Although multiple evidences suggest that angiogenesis is associated with the pathophysiology of rosacea, its role is still in debate. Here, we showed that angiogenesis was enhanced in skin lesions of both rosacea patients and LL37-induced rosacea-like ...
Qinqin Peng +33 more
doaj +1 more source
Combination Therapy With Rapamycin and Low Dose Imatinib in Pulmonary Hypertension
Frontiers in Pharmacology, 2021 Rationale: Enhanced proliferation and distal migration of human pulmonary arterial smooth muscle cells (hPASMCs) both contribute to the progressive increases in pulmonary vascular remodeling and resistance in pulmonary arterial hypertension (PAH).
Yinan Shi +15 more
doaj +1 more source
Enhancement of the Tolerogenic Phenotype in the Liver by ImmTOR Nanoparticles
Frontiers in Immunology, 2021 ImmTOR biodegradable nanoparticles encapsulating rapamycin have been shown to induce a durable tolerogenic immune response to co-administered biologics and gene therapy vectors.
Petr O. Ilyinskii +4 more
doaj +1 more source