Results 1 to 10 of about 154,401 (120)
Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast
Cells, 2021 Cells have developed response systems to constantly monitor environmental changes and accordingly adjust growth, differentiation, and cellular stress programs.
John-Patrick Alao +2 more
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Cells, 2022 Human adipose-derived stem cells (hASCs) are potent modulators of inflammation and promising candidates for the treatment of inflammatory and autoimmune diseases. Strategies to improve hASC survival and immunoregulation are active areas of investigation.
Rachel M. Wise +7 more
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Folia Histochemica et Cytobiologica, 2023 INTRODUCTION: High-fructose, high-fat diet consumption (HFHF) is one of the primary causes of non-alcoholic fatty liver disease (NAFLD), which is due to impaired beta-oxidation or apolipoprotein secretion by hepatocytes.
Sara Adel Hosny +3 more
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Bioengineering & Translational Medicine, 2023 Trauma to the knee joint is associated with significant cartilage degeneration and erosion of subchondral bone, which eventually leads to osteoarthritis (OA), resulting in substantial morbidity and healthcare burden.
Kaamini M. Dhanabalan +5 more
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Mixed Polymeric Micelles for Rapamycin Skin Delivery
Pharmaceutics, 2022 Facial angiofibromas (FA) are one of the most obvious cutaneous manifestations of tuberous sclerosis complex. Topical rapamycin for angiofibromas has been reported as a promising treatment. Several types of vehicles have been used hitherto, but polymeric
Guillaume Le Guyader +8 more
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Frontiers in Microbiology, 2022 Hepatitis B virus (HBV) infection is still a serious public health problem worldwide. Antiviral therapies such as interferon and nucleos(t)ide analogs efficiently control HBV replication, but they cannot eradicate chronic hepatitis B (CHB) because of ...
Yuan Zhang +18 more
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Wood-Derived Vascular Patches Loaded With Rapamycin Inhibit Neointimal Hyperplasia
Frontiers in Bioengineering and Biotechnology, 2022 Background: Patches are commonly used to close blood vessels after vascular surgery. Most currently used materials are either prosthetics or animal-derived; although natural materials, such as a leaf, can be used as a patch, healing of these natural ...
Boao Xie +8 more
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Frontiers in Oncology, 2021 PurposeOverexpression of breast cancer (BCa) resistance protein (BCRP) is detected in approximately 30% of BCa cases. BCRP indicates a poor response to chemotherapy, and it has become a classic target to overcome drug-resistant tumor cells. In this study,
Jing Zhang +18 more
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Frontiers in Genetics, 2020 DNA methylation is an indispensable epigenetic modification that dynamically regulates gene expression and genome stability during cell growth and development processes.
Tingting Zhu +7 more
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Rapamycin: Drug Repurposing in SARS-CoV-2 Infection
Pharmaceuticals, 2021 Since December 2019, SARS-CoV-2 (COVID-19) has been a worldwide pandemic with enormous consequences for human health and the world economy. Remdesivir is the only drug in the world that has been approved for the treating of COVID-19.
Jiri Patocka +6 more
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