Results 101 to 110 of about 253,061 (341)

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

An Autocrine TNFα–Tumor Necrosis Factor Receptor 2 Loop Promotes Epigenetic Effects Inducing Human Treg Stability In Vitro

Frontiers in Immunology, 2018
A crucial issue for Treg-based immunotherapy is to maintain a bona fide Treg phenotype as well as suppressive function during and after ex vivo expansion. Several strategies have been applied to harness Treg lineage stability.
Paulo C. M. Urbano, Hans J. P. M. Koenen, Irma Joosten, Xuehui He, Xuehui He   +4 more
doaj   +1 more source

Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies [PDF]

, 2016
OBJECTIVES: Autophagy may represent a functional processing event that creates a substrate for autoreactivity. In particular, autophagy may play a role in the pathogenesis of RA, since autophagy is a key cellular event involved in the generation of ...
Alessandra Nerviani, Antonella Capozzi, Cristiano Alessandri, Cristina Iannuccelli, Emanuela Lococo, Guido Valesini, Kato, Manuela Di Franco, Maurizio Sorice, Michele Bombardieri, Neumann, Pickl, Roberta Misasi, Tina Garofalo, Valeria Manganelli   +14 more
core   +1 more source

Multifaceted aging and rapamycin

Aging, 2013
Aging is commonly defined as a time-dependent loss of physiological integrity, leading to the decline and impair in organism functions and to the increase of risk for cancer and other major age-associated diseases, finally increasing vulnerability to death [1].
openaire   +3 more sources

p53 and rapamycin are additive

Oncotarget, 2015
Mechanistic target of rapamycin (mTOR) is a kinase found in a complex (mTORC1) that enables macromolecular synthesis and cell growth and is implicated in cancer etiology. The rapamycin-FK506 binding protein 12 (FKBP12) complex allosterically inhibits mTORC1.
Carolina B. Livi, Carolina B. Livi, Xiaoli Gao, Diane Jones, Tyler J. Curiel, Judith Campisi, Sherry G. Dodds, Susan T. Weintraub, Barbara A. Christy, Marco Demaria, Gene B. Hubbard, Z. Dave Sharp, Paul Hasty, Charnae Williams, Jing Huang   +14 more
openaire   +4 more sources

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Mechanistic target of rapamycin (mTOR) signaling genes in decapod crustaceans: cloning and tissue expression of mTOR, Akt, Rheb, and S6 kinase in the green crab, Carcinus maenas, and blackback land crab, Gecarcinus lateralis [PDF]

, 2014
Mechanistic target of rapamycin (mTOR) controls global translation of mRNA into protein by phosphorylating p70 S6 kinase (S6K) and eIF4E-binding protein-1. Akt and Rheb, a GTP-binding protein, regulate mTOR protein kinase activity. Molting in crustaceans
Abuhagr, Ali M., Chang, Ernest S., MacLea, Kyle S., Mykles, Donald L.   +3 more
core   +2 more sources

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

Advanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso, Sara Carpi, Laura Colagiorgio, Miriam De Sarlo, Mariacristina Gagliardi, Marco Cecchini   +5 more
wiley   +1 more source

Neuroprotective effect of rapamycin on spinal cord injury via activation of the Wnt/β-catenin signaling pathway

Neural Regeneration Research, 2015
The Wnt/β-catenin signaling pathway plays a crucial role in neural development, axonal guidance, neuropathic pain remission and neuronal survival. In this study, we initially examined the effect of rapamycin on the Wnt/β-catenin signaling pathway after ...
Kai Gao, Yan-song Wang, Ya-jiang Yuan, Zhang-hui Wan, Tian-chen Yao, Hai-hong Li, Pei-fu Tang, Xi-fan Mei   +7 more
doaj   +1 more source

Rapamycin and abundant TCR stimulation are required for the generation of stable human induced regulatory T cells

Clinical & Translational Immunology, 2020
Objectives Regulatory T cells (Tregs) are a vital sub‐population of CD4+ T cells with major roles in immune tolerance and homeostasis. Given such properties, the use of regulatory T cells for immunotherapies has been extensively investigated, with a ...
Juewan Kim, Christopher M Hope, Griffith B Perkins, Sebastian O Stead, Jacqueline C Scaffidi, Francis D Kette, Robert P Carroll, Simon C Barry, Patrick Toby Coates   +8 more
doaj   +1 more source