Results 111 to 120 of about 159,720 (266)
Rational Design of Polyketide Natural Products
Food Technology and Biotechnology, 2005 Compounds of polyketide origin possess a wealth of pharmacological effects, including antibacterial, antifungal, antiparasitic, anticancer and immunosuppressive activities.
Enej Kuščer +2 more
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Animal Research and One Health, EarlyView.In this study, we used cross‐species comparisons to identify ruminant hepatocyte features. We also identified potential genes and TFs involved in coordinating gluconeogenesis in ruminant hepatocytes. By integrating single‐cell data with population genetic analyses, we further identified candidate genetic variation in glucose metabolism and ...
Yaqi Zhou +6 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Dermal systemic sclerosis (SSc) fibroblasts and their exosomes can activate keratinocytes in SSc, with long noncoding RNA (lncRNA) H19 highlighted as the most up‐regulated RNA in their cargo compared with healthy controls (HCs). The role of H19 in SSc pathogenesis has never been investigated.
Begoña Caballero‐Ruiz +3 more
wiley +1 more source
Distinct Molecular Pathways Supporting Sjögren Disease Clusters and Disease Progression
Arthritis &Rheumatology, EarlyView.Objective Sjögren disease (SjD) is a heterogeneous autoimmune disease. We aimed to investigate blood transcriptomic signatures and disease progression among three recently defined clusters of patients with SjD: (1) B cell active disease with low symptom burden (BALS), (2) high systemic activity (HSA), and (3) low systemic activity with high symptom ...
Sacha E. Silva‐Saffar +6 more
wiley +1 more source
Exploring new avenues: Psychedelic‐assisted therapy for young people
British Journal of Clinical Pharmacology, EarlyView.Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou +3 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Sirolimus is currently used off‐label for paediatric patients with vascular anomalies. However, the optimal dosage regimen for paediatric patients remains controversial. This study aimed to determine the optimal dosing regimen of sirolimus in these patients using a population pharmacokinetic (PK) model.
Seongmee Jeong +13 more
wiley +1 more source
Long-term rapamycin treatment suppresses IL-17-producing gamma delta T cells and blunts neuroinflammation in aging. [PDF]
PLoS OneTorrent C +8 more
europepmc +1 more source
Drug‐coated balloons: From conventional designs to next‐generation innovations in vascular therapy
BMEMat, EarlyView.This review traces the evolution of drug‐coated balloons (DCBs) from conventional designs to next‐generation platforms. We highlight innovations in balloon engineering, coating technologies, and therapeutic agents that enhance localized drug delivery while addressing challenges in efficiency, safety, and biocompatibility for vascular and emerging non ...
Lu Zhang +5 more
wiley +1 more source
Fpr1p mediates the synergistic effect of rapamycin or tacrolimus with caspofungin in <i>Clavispora lusitaniae in vitro</i>. [PDF]
JAC Antimicrob ResistLefranc M +4 more
europepmc +1 more source