Results 121 to 130 of about 164,975 (264)

The Role of the Mammalian Target of Rapamycin in Microglial Phenotypic Polarization. [PDF]

Cells
Partridge KJ, Ebert AD.
europepmc   +1 more source

5-Fluorouracil-based chemotherapy disrupts autophagy flux and protein synthesis in cultured myotubes: a role for mTORC1 signaling. [PDF]

Am J Physiol Cell Physiol
Halle JL, Zhang Q, Jenkins T, Carson JA.
europepmc   +1 more source

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

Angewandte Chemie International Edition, EarlyView.
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

<i>Caenorhabditis</i> Intervention Testing Program: the putative mTOR inhibitors Cinnarizine and Meclizine do not extend lifespan in <i>C. elegans</i>. [PDF]

MicroPubl Biol
Johnson E, Sedore CA, Coleman-Hulbert AL, Onken BD, Achanta VM, Song Y, Cortopassi G, Lithgow GJ, Driscoll M, Phillips PC.   +9 more
europepmc   +1 more source

Abnormal KCC2 expression and function in a mouse model of epilepsy and tuberous sclerosis complex. [PDF]

Epilepsia
Abstract Objective Drug‐resistant epilepsy is a common, severe manifestation of the genetic disorder tuberous sclerosis complex (TSC). Although significant mechanistic and therapeutic advances have been made in TSC, treatments for seizures remain largely ineffective.
Guo D, Han L, Rensing NR, Jansen LA, Wong M.   +4 more
europepmc   +2 more sources

Glucose-TOR Signaling Regulates Root Hair Elongation in <i>Arabidopsis</i> via the RHD6-RSL4 Transcriptional Cascade. [PDF]

Plants (Basel)
Wang B, Zhang J, Yan W, Dai X, Zhang J, Zhang T, Deng K.   +6 more
europepmc   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges. [PDF]

Neuroprotection
Manavi MA, Salehi M, Mohammad Jafari R, Goudarzi R, Khosravi S, Dehpour AR.   +5 more
europepmc   +1 more source

MicroRNA‐Seq Analysis Reveals a Critical Role for miR‐222 in Bovine Intramuscular Adipogenesis via the DDIT4/mTORC1 Axis

Animal Research and One Health, EarlyView.
Schematic diagram illustrating how miR‐222 promotes bovine intramuscular adipogenesis by targeting DDIT4 to activate the mTORC1 signaling pathway. ABSTRACT Intramuscular fat (IMF) is a key determinant of beef quality, particularly with respect to tenderness, flavor, and juiciness.
Jianbing Tan, Liang Qiu, Zhenghai Zhou, Zhipeng Zhang, Nanfei Wang, Jiangang Hao, Linsen Zan, Wucai Yang   +7 more
wiley   +1 more source

Evaluation of Human Serum Albumin Nanoparticles for Rapamycin Delivery. [PDF]

ACS Omega
Rodero CF, Pangua C, Gracia JM, Suner MB, Guiguer MT, Chorilli M, Irache JM.   +6 more
europepmc   +1 more source