Results 221 to 230 of about 255,378 (313)

Near infrared light controlled gene editing. [PDF]

Light Sci Appl
Berezin MY.
europepmc   +1 more source

Exome Sequencing Identifies Variants in MLH1 and ERBB2 as Potential Cancer‐Predisposing Factors in Familial Early‐Onset Colorectal Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Colorectal cancer (CRC) has raised considerable health concerns worldwide, with increasing incidence rates, specifically among younger populations. Despite remarkable progress in diagnosing and treating various diseases, the genetic basis of CRC remains only partially understood.
Behnaz Bagheri, Neda Mohsen‐Pour, Najmeh Salehi, Pardis Ketabi Moghadam, Adel Zeinalpour, Amir Sadeghi, Samira Kalayinia, Nayeralsadat Fatemi   +7 more
wiley   +1 more source

Autophagy hub genes mediate photodynamic therapy tolerance in nasopharyngeal carcinoma through cytoprotective autophagy and survival signaling. [PDF]

J Mol Histol
Peng Y, Wen D, Bing Y, Di C, Jian K.
europepmc   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Advancing DIA-Based Limited Proteolysis Workflows: Introducing DIA-LiPA. [PDF]

Anal Chem
Van Leene C, Araftpoor E, Staes A, Argentini A, Bühler M, Clement L, Gevaert K.   +6 more
europepmc   +1 more source

Triacylglycerol‐Based Insulin Resistance Indices and Post‐Transplantation Diabetes Mellitus After Liver Transplantation

Lipids, EarlyView.
ABSTRACT Background: Post‐transplant diabetes mellitus (PTDM) is a common complication following liver transplant (LT) and is associated with adverse outcomes. The triacylglycerol‐glucose product (TyG) and the triacylglycerol‐to‐high‐density lipoprotein (HDL) cholesterol ratio (TAG/HDL‐c) are indices that can serve as triacylglycerol‐based proxies for ...
Mateo Chvatal‐Medina, Yakun Li, Adrian Post, Margery A. Connelly, Han Moshage, Stephan J. L. Bakker, Vincent E. de Meijer, Hans Blokzijl, Robin P. F. Dullaart, on behalf of TransplantLines investigators   +9 more
wiley   +1 more source

mTOR signalling mediates the spinal osteoblast pathotype at the curve apex in adolescent idiopathic scoliosis

Northall EH, Nicholson TA, Hazeldine J, Grover LM, McGettrick HM, Ede MN, Naylor AJ, Jones SW.   +7 more
europepmc   +1 more source

Rapamycin-mediated inhibition of the mTOR pathway promotes tendon healing in a collagenase-induced achilles tendinopathy. [PDF]

J Orthop Surg Res
Zhang E, Wang X, Zhou Z, Zhang C.
europepmc   +1 more source

Ift46 deficiency causes renal cyst via enhanced Limk2 through lack of autophagy flux. [PDF]

Cell Commun Signal
Jun JH, Ko JY, Lee EJ, Min J, Choi H, Lee GR, Jung S, Yoo KH, Park JH.   +8 more
europepmc   +1 more source

Movement Disorders Associated with 22q11.2 Microdeletion: A Scoping Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Movement disorders have recently emerged as important neurologic manifestations of the 22q11.2 microdeletion that affects nearly one in every 2000 live births. Objective We aimed to map the existing evidence regarding the spectrum, diagnosis and treatment, and etiopathogenesis of movement disorders associated with 22q11.2 ...
Nikolai Gil D. Reyes, Daniel G. Di Luca, Connie Marras, Erik Boot, Ryan K.C. Yuen, Anthony E. Lang, Anne S. Bassett   +6 more
wiley   +1 more source